Animal Models of Pulmonary Vascular Disease and Therapy

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A

Hanrong Cheng, Li Chen, Yongli Wei, Tianyong Hu, Dongcai Li, Benqing WuShenzhen People’s Hospital, The Second Clinical Medical College of Jinan University and First Affiliated Hospital of Southern University of Science and Technology. Longgang ENT Hospital.University of Chinese Academy of Science-Shenzhen Hospital.China Journal of Bioenergetics and BiomembranesJ Bioenerg Biomembr 2021; 53: 13-23DOI: 10.1007/s10863-020-09863-3 AbstractBronchopulmonary dysplasia (BPD) […]

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A Read More »

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions

Evan M. Zahn, Eason Abbott, Neil Tailor, Shyam Sathanandam, Dustin ArmerCedars Sinai Medical Center. Renata Medical Company. Morgan Stanley Children’s Hospital. LeBonheur Children’s Hospital.United States Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv 2021; 98: 117-127DOI: 10.1002/ccd.29706 AbstractObjectives: This study sought to obtain in vivo data on a new stent and delivery system specifically designed for implantation in infants

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions Read More »

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin.United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 2365-2376DOI: 10.1007/s10439-021-02780-5 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and the pressure gradient over a stenotic PA lesion is an important marker for re-intervention. Image based computational fluid dynamics (CFD) has shown promise for non-invasively

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine Read More »

Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model

Ryan J. Pewowaruk, Gregory P. Barton, Cody Johnson, J. Carter Ralphe, Christopher J. Francois, Luke Lamers, Alejandro Roldán‑AlzateUniversity of Wisconsin-Madison.United States Journal of Cardiovascular Magnetic ResonanceJ Cardiovasc Magn Reson 2021; 13: DOI: 10.1186/s12968-021-00709-4 AbstractBackground: Branch pulmonary artery (PA) stenosis (PAS) commonly occurs in patients with congenital heart disease (CHD). Prior studies have documented technical success and clinical

Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model Read More »

Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin. United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 1477-1492DOI: 10.1007/s10439-020-02696-6 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and it has previously been hypothesized that in branch PAS the pulmonary arteries (PAs) remodel their lumen diameter to maintain constant wall shear stress (WSS).

Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions Read More »

Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine

Ryan Pewowaruk, J. Carter Ralphe, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin. William S. Middleton Memorial Veteran’s Hospital. United States Cardiovascular Engineering and TechnologyCardiovasc Eng Technol 2021; 12: 494-504DOI: 10.1007/s13239-021-00543-w AbstractObjective: This study assessed the ability of hemodynamic simulations to predict the success of catheter interventions in a swine model of branch pulmonary artery stenosis (bPAS).Background: bPAS commonly occurs

Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine Read More »

SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension

Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, Olin D. Liang, Ali Ashek, Olivier Dubois, Lin Zhao, Farah Sabrin, Inês Cebola, Jorge Ferrer, Nicholas W. Morrell, James R. Klinger, Martin R. Wilkins, Lan Zhao, Christopher J. RhodesHammersmith Hospital and Imperial College. Amsterdam University Medical Center. Rhode Island Hospital and Warren Alpert Medical School

SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension Read More »

Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis

Richard W. B. van Duin, Kelly Stam, André Uitterdijk, Beatrijs Bartelds, A. H. Jan Danser, Irwin K. M. Reiss, Dirk J. Duncker, Daphne MerkusErasmus MC Rotterdam. Sophia Children’s Hospital. University Hospital, LMU Munich.Netherlands and Germany Journal of Clinical MedicineJ Clin Med 2019; 8: DOI: 10.3390/jcm8081204 AbstractPulmonary hypertension (PH) as a result of pulmonary vein stenosis (PVS)

Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis Read More »

Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload

Vitaly O. Kheyfets, Sushil Kumar, Paul M. Heerdt, Kenzo Ichimura, R. Dale Brown, Melissa Lucero, Ilham Essafri, Sarah Williams, Kurt R. Stenmark, Edda SpiekerkoetterUniversity of Colorado. Yale School of Medicine. Stanford University. he University of Queensland.United States and Australia International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24119746 AbstractThis study analyzed microarray data

Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload Read More »

Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration

Ishmael Miguel Inocencio, Navneet Kaur, Nhi T. Tran, Flora Y. WongThe Hudson Institute of Medical Research, Monash Children’s Hospital and Monash University.Australia Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1101647 AbstractBackground: Neurovascular coupling (NVC) leads to an increase in local cerebral blood flow and oxygenation in response to increased neural activity and metabolic demand. Impaired or immature

Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration Read More »

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