Animal Models of Pulmonary Vascular Disease and Therapy

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin.United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 2365-2376DOI: 10.1007/s10439-021-02780-5 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and the pressure gradient over a stenotic PA lesion is an important marker for re-intervention. Image based computational fluid dynamics (CFD) has shown promise for non-invasively […]

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine Read More »

Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model

Ryan J. Pewowaruk, Gregory P. Barton, Cody Johnson, J. Carter Ralphe, Christopher J. Francois, Luke Lamers, Alejandro Roldán‑AlzateUniversity of Wisconsin-Madison.United States Journal of Cardiovascular Magnetic ResonanceJ Cardiovasc Magn Reson 2021; 13: DOI: 10.1186/s12968-021-00709-4 AbstractBackground: Branch pulmonary artery (PA) stenosis (PAS) commonly occurs in patients with congenital heart disease (CHD). Prior studies have documented technical success and clinical

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Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin. United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 1477-1492DOI: 10.1007/s10439-020-02696-6 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and it has previously been hypothesized that in branch PAS the pulmonary arteries (PAs) remodel their lumen diameter to maintain constant wall shear stress (WSS).

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Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine

Ryan Pewowaruk, J. Carter Ralphe, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin. William S. Middleton Memorial Veteran’s Hospital. United States Cardiovascular Engineering and TechnologyCardiovasc Eng Technol 2021; 12: 494-504DOI: 10.1007/s13239-021-00543-w AbstractObjective: This study assessed the ability of hemodynamic simulations to predict the success of catheter interventions in a swine model of branch pulmonary artery stenosis (bPAS).Background: bPAS commonly occurs

Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine Read More »

SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension

Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, Olin D. Liang, Ali Ashek, Olivier Dubois, Lin Zhao, Farah Sabrin, Inês Cebola, Jorge Ferrer, Nicholas W. Morrell, James R. Klinger, Martin R. Wilkins, Lan Zhao, Christopher J. RhodesHammersmith Hospital and Imperial College. Amsterdam University Medical Center. Rhode Island Hospital and Warren Alpert Medical School

SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension Read More »

Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis

Richard W. B. van Duin, Kelly Stam, André Uitterdijk, Beatrijs Bartelds, A. H. Jan Danser, Irwin K. M. Reiss, Dirk J. Duncker, Daphne MerkusErasmus MC Rotterdam. Sophia Children’s Hospital. University Hospital, LMU Munich.Netherlands and Germany Journal of Clinical MedicineJ Clin Med 2019; 8: DOI: 10.3390/jcm8081204 AbstractPulmonary hypertension (PH) as a result of pulmonary vein stenosis (PVS)

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Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload

Vitaly O. Kheyfets, Sushil Kumar, Paul M. Heerdt, Kenzo Ichimura, R. Dale Brown, Melissa Lucero, Ilham Essafri, Sarah Williams, Kurt R. Stenmark, Edda SpiekerkoetterUniversity of Colorado. Yale School of Medicine. Stanford University. he University of Queensland.United States and Australia International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24119746 AbstractThis study analyzed microarray data

Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload Read More »

Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration

Ishmael Miguel Inocencio, Navneet Kaur, Nhi T. Tran, Flora Y. WongThe Hudson Institute of Medical Research, Monash Children’s Hospital and Monash University.Australia Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1101647 AbstractBackground: Neurovascular coupling (NVC) leads to an increase in local cerebral blood flow and oxygenation in response to increased neural activity and metabolic demand. Impaired or immature

Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration Read More »

Zymosan Particle-Induced Hemodynamic, Cytokine and Blood Cell Changes in Pigs: An Innate Immune Stimulation Model with Relevance to Cytokine Storm Syndrome and Severe COVID-19

Gábor Kökény, Tamás Bakos, Bálint András Barta, Georgina Viktória Nagy, Tamás Mészáros, Gergely T. Kozma, András Szabó, János Szebeni, Béla Merkely, Tamás RadovitsSemmelweis University. Sungkyunkwan University.Hungary and Republic of Korea International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24021138 AbstractHemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of inflammatory cytokines into

Zymosan Particle-Induced Hemodynamic, Cytokine and Blood Cell Changes in Pigs: An Innate Immune Stimulation Model with Relevance to Cytokine Storm Syndrome and Severe COVID-19 Read More »

Inhaled Nitric Oxide Promotes Angiogenesis in the Rodent Developing Brain

Gauthier Loron, Julien Pansiot, Paul Olivier, Christiane Charriaut-Marlangue, Olivier BaudUniversité de Reims Champagne-Ardenne. Université Paris Cité. Children’s University Hospital of Geneva.France and Switzerland International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24065871 AbstractInhaled nitric oxide (iNO) is a therapy used in neonates with pulmonary hypertension. Some evidence of its neuroprotective properties has been

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