Animal Models of Pulmonary Vascular Disease and Therapy

Microenvironmental regulation of T-cells in pulmonary hypertension

Lydie Plecita-Hlavata, Andrea Brazdova, MonikaKrivonoskova, Cheng-Jun Hu, Tzu Phang, Jan Tauber, Min Li, Hui Zhang, Konrad Hoetzenecker, Slaven Crnkovic, Grazyna Kwapiszewska, Kurt R. StenmarkCzech Academy of Sciences. Charles University. University of Colorado. Medical University of Vienna. Ludwig Boltzmann Institute for Lung Vascular Research. Institute for Lung Health.Czechia, United Stated, Austria and Germany Frontiers in ImmunologyFront […]

Microenvironmental regulation of T-cells in pulmonary hypertension Read More »

Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats

Shiho Yoshida, Alexander M. Kreger, George K. Gittes UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh School of Medicine.United States Frontiers in Bioengineering and BiotechnologyFront Bioeng Biotechnol 2023; DOI: 10.3389/fbioe.2023.1195623 AbstractPulmonary hypertension associated with congenital diaphragmatic hernia (CDH) is a critical factor in determining prognosis. We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for

Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats Read More »

Vasopressin versus epinephrine during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets

Megan O’Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. SchmolzerRoyal Alexandra Hospital and University of Alberta.Canada Resuscitation PlusResus Plus 2023; 15DOI: 10.1016/j.resplu.2023.100427 AbstractBackground: Epinephrine is currently the only recommended cardio-resuscitative medication for use in neonatal cardiopulmonary resuscitation (CPR), as per the consensus of science and treatment recommendations. An alternative medication, vasopressin, might be beneficial in neonatal CPR due

Vasopressin versus epinephrine during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets Read More »

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics

Shreya Sangam, Xutong Sun, Tae-Hwi Schwantes-An, Manivannan Yegambaram, Qing Lu, Yinan Shi, Todd Cook, Amanda Fisher, Andrea L. Frump, Anna Coleman, Yanan Sun, Shuxin Liang, Howard Crawford, Katie A. Lutz, Avinash D. Maun, Michael W. Pauciulo, Jason H. Karnes, Ketul R. Chaudhary, Duncan J. Stewart, Paul R. Langlais, Mohit Jain, Mona Alotaibi, Tim Lahm, Yan

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics Read More »

Drug-eluting stents ameliorate pulmonary vein stenotic changes in pigs in vivo

Takeshi Furukawa, Masahiko Kishiro, Hideo Fukunaga, Masahiro Ohtsuki, Ken Takahashi, Katsumi Akimoto, Toshiaki Shimizu, Shiori Kawasaki, Toshio KumasakaJuntendo University School of Medicine.Japan Pediatric CardiologyPediatr Cardiol 2010; 31: 773-779DOI: 10.1007/s00246-010-9695-8 AbstractThe outcome of stent implantation for pulmonary vein stenosis (PVS) in children remains poor. Several reports describe placing drug-eluting stents to treat PVS, but their effectiveness remains

Drug-eluting stents ameliorate pulmonary vein stenotic changes in pigs in vivo Read More »

Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis

Jiaquan Zhu, HarukiIde, Yaqin Yana Fu, Anouk-Martine Teichert, Hideyuki Kato, Richard D. Weisel, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneThe Hospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2014; 148: 2550-2557DOI: 10.1016/j.jtcvs.2014.07.050 AbstractObjectives: Pulmonary vein stenosis (PVS) is a relentless disease with

Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis Read More »

Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins

Hideyuki Kato, Yaqin Yana Fu, Jiaquan Zhu, Shabana Aafaqi, Otto Rahkonen, Cameron Slorach, Alexandra Traister, Chung Ho Leung, David Chiasson, Luc Mertens, Lee Benson, Richard D. Weisel, Boris Hinz, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneHospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ

Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins Read More »

Pulmonary hypertension due to left heart disease causes intrapulmonary venous arterialization in rats

Yoshitaka Fujimoto, Takashi Urashima, Fumie Kawachi, Toru Akaike, Yoichiro Kusakari, Hiroyuki Ida, Susumu MinamisawaJikei University School of Medicine.Japan Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovas Surg 2017; 154: 1742-1753DOI: 10.1016/j.jtcvs.2017.06.053 AbstractObjective: A rat model of left atrial stenosis-associated pulmonary hypertension due to left heart diseases was prepared to elucidate its mechanism.Methods: Five-week-old Sprague-Dawley rats were randomly divided

Pulmonary hypertension due to left heart disease causes intrapulmonary venous arterialization in rats Read More »

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A

Hanrong Cheng, Li Chen, Yongli Wei, Tianyong Hu, Dongcai Li, Benqing WuShenzhen People’s Hospital, The Second Clinical Medical College of Jinan University and First Affiliated Hospital of Southern University of Science and Technology. Longgang ENT Hospital.University of Chinese Academy of Science-Shenzhen Hospital.China Journal of Bioenergetics and BiomembranesJ Bioenerg Biomembr 2021; 53: 13-23DOI: 10.1007/s10863-020-09863-3 AbstractBronchopulmonary dysplasia (BPD)

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A Read More »

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions

Evan M. Zahn, Eason Abbott, Neil Tailor, Shyam Sathanandam, Dustin ArmerCedars Sinai Medical Center. Renata Medical Company. Morgan Stanley Children’s Hospital. LeBonheur Children’s Hospital.United States Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv 2021; 98: 117-127DOI: 10.1002/ccd.29706 AbstractObjectives: This study sought to obtain in vivo data on a new stent and delivery system specifically designed for implantation in infants

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions Read More »

Scroll to Top