Animal Models of Pulmonary Vascular Disease and Therapy

A neonatal rat model of pulmonary vein stenosis

Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University. Second Affiliated Hospital and Yuying Children’s Hospital and Wenzhou Medical University.China Cell and BioscienceCell Biosci 2023; 13:DOI: 10.1186/s13578-023-01058-8 AbstractObjectives: Pulmonary vein stenosis (PVS), one of the most challenging clinical problems in […]

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Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Haiyang Tang, Akash Gupta, Seth A. Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R. Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A. Warfel, Louise Hecker, Sumegha Mitra, Anna W. Coleman, Katie A. Lutz, Michael W. Pauciulo, Yen-Chun Lai, Ali Javaheri,

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Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. StenmarkUniversity of Colorado School of Medicine. University of California San Francisco. Zuckerberg San Francisco General Hospital.United States Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1372959 AbstractIntroduction: Hypoxia

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The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

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Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension

Michael G. Katz, Yoav Hadas, Nataly Shtraizent, Shana Ravvin, Jeko M. Madjarov, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Wake Forest School of Medicine. United States Methods in Molecular BiologyMethods Mol Biol 2024; 2803: 173-185DOI: 10.1007/978-1-0716-3846-0_13 AbstractPulmonary hypertension (PH) is a chronic and progressive disorder characterized by elevated mean pulmonary arterial pressure, pulmonary vascular remodeling,

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension Read More »

A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy

Abraham Rothman, David Mann, Jose A. Nunez, Reinhardt Tarmidi, Humberto Restrepo, Valeri Sarukhanov, Roy Williams, William N. EvansChildren’s Heart Center Nevada. Kirk Kerkorian School of Medicine at UNLV. Vascular Biosciences. University of California, Santa Barbara. University of California, San Diego.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-230927-2023-9 AbstractBackground: Optimal pharmacological therapy for pulmonary

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GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

Xuran Chu, Vahid Kheirollahi, Arun Lingampally, Prakash Chelladurai, Chanil Valasarajan, Ana Ivonne Vasquez-Armendariz, Stefan Hadzic, Ali Khadim, Oleg Pak, Stefano Rivetti, Jochen Wilhelm, Marek Bartkuhn, Slaven Crnkovic, Alena Moiseenko, Mohika Heiner, Simone Kraut, Leila Sotoodeh, Janine Koepke, Guilherme Valente, Clemens Ruppert, Thomas Braun, Christos SamakovlisIoannis Alexopoulos, MAria Looso, Cho-Mong Chao, Susanne Herold, Werner Seeger, Grazyna

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PKD1L1 Is Involved in Congenital Chylothorax

Jonathan B. Whitchurch, Sophia Schneider, Alina C. Hilger, Ricarda Köllges, Jil D. Stegmann, Lea Waffenschmidt, Laura Dyer, Holger Thiele, Bhanupriya Dhabhai, Tikam Chand Dakal, Andreas Müller, Dominic P. Norris, Heiko M. ReutterHarwell Campus. University Hospital Bonn. University Hospital Erlangen. University of Cologne. Mohanlal Sukhadia University.United Kingdom, Germany and India CellsCells 2024; 13:DOI: 10.3390/cells13020149 AbstractBesides visceral heterotaxia, Pkd1l1 null

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Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells

Chanéle Cyr-Depauw, David P. Cook, Ivana Mizik, Flore Legase, Arul Vadivel, Laurent Renesme, Yupu Deng, Shumei Zhong, Pauline Bardin, Liqun Xu, Marius A. Möbius, Jenny Marzahn, Daniel Freund, Duncan J. Stewart, Barbara C. Vanderhyden, Mario Rüdiger, Bernard ThébaudOttawa Hospital Research Institute. University of Ottawa. Universitätsklinikum Carl Gustav Carus. Technische Universität Dresden. Children’s Hospital of Eastern

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Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension

Nicolas Philip, Xin Yun, Hongyang Pi, Samuel Murray, Zack Hill, Jay Fonticella, Preston Perez, Cissy Zhang, Wimal Pathmasiri, Susan Sumner, Laura Servinsky, Haiyang Jiang, John C. Huetsch, William M. Oldham, Scott Visovatti, Peter J. Leary, Sina A. Gharib, Evan Brittain, Catherine E. Simpson, Anne Le, Larissa A. Shimoda, Karthik SureshJohns Hopkins University School of Medicine.

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