Animal Models of Pulmonary Vascular Disease and Therapy

Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis

Richard W. B. van Duin, Kelly Stam, André Uitterdijk, Beatrijs Bartelds, A. H. Jan Danser, Irwin K. M. Reiss, Dirk J. Duncker, Daphne MerkusErasmus MC Rotterdam. Sophia Children’s Hospital. University Hospital, LMU Munich.Netherlands and Germany Journal of Clinical MedicineJ Clin Med 2019; 8: DOI: 10.3390/jcm8081204 AbstractPulmonary hypertension (PH) as a result of pulmonary vein stenosis (PVS) […]

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Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload

Vitaly O. Kheyfets, Sushil Kumar, Paul M. Heerdt, Kenzo Ichimura, R. Dale Brown, Melissa Lucero, Ilham Essafri, Sarah Williams, Kurt R. Stenmark, Edda SpiekerkoetterUniversity of Colorado. Yale School of Medicine. Stanford University. he University of Queensland.United States and Australia International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24119746 AbstractThis study analyzed microarray data

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Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration

Ishmael Miguel Inocencio, Navneet Kaur, Nhi T. Tran, Flora Y. WongThe Hudson Institute of Medical Research, Monash Children’s Hospital and Monash University.Australia Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1101647 AbstractBackground: Neurovascular coupling (NVC) leads to an increase in local cerebral blood flow and oxygenation in response to increased neural activity and metabolic demand. Impaired or immature

Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration Read More »

Zymosan Particle-Induced Hemodynamic, Cytokine and Blood Cell Changes in Pigs: An Innate Immune Stimulation Model with Relevance to Cytokine Storm Syndrome and Severe COVID-19

Gábor Kökény, Tamás Bakos, Bálint András Barta, Georgina Viktória Nagy, Tamás Mészáros, Gergely T. Kozma, András Szabó, János Szebeni, Béla Merkely, Tamás RadovitsSemmelweis University. Sungkyunkwan University.Hungary and Republic of Korea International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24021138 AbstractHemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of inflammatory cytokines into

Zymosan Particle-Induced Hemodynamic, Cytokine and Blood Cell Changes in Pigs: An Innate Immune Stimulation Model with Relevance to Cytokine Storm Syndrome and Severe COVID-19 Read More »

Inhaled Nitric Oxide Promotes Angiogenesis in the Rodent Developing Brain

Gauthier Loron, Julien Pansiot, Paul Olivier, Christiane Charriaut-Marlangue, Olivier BaudUniversité de Reims Champagne-Ardenne. Université Paris Cité. Children’s University Hospital of Geneva.France and Switzerland International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24065871 AbstractInhaled nitric oxide (iNO) is a therapy used in neonates with pulmonary hypertension. Some evidence of its neuroprotective properties has been

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Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia

Arun Pradhan, Lixiao Che, Vladimir Ustiyan, Abid A. Reza, Nicole M. Pek, Yufang Zhang, Andrea B. Alber, Timothy R. Kalin, Jennifer A. Wambach, Mingxia Gu, Darrell N. Kotton, Matthew E. Siefert, Assem G. Ziady, Tanya V. Kalin, Vladimir V. KalinichenkoBoston University and Boston Medical Center. University of Cincinnati. Washington University in St. Louis School of

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Regulatory B cells protect against chronic hypoxia-induced pulmonary hypertension by modulating the Tfh/Tfr immune balance

Cheng Li, Pingping Liu, Huiling Yao, Hao Zhu, Shaoze Zhang, Famg Meng, San Li, Guang Li, Yanping Peng, Jing Gu, Liming Zhu, Yongliang Jiang, Aiguo DaiHunan Provincial People’s Hospital and The First Affiliated Hospital of Hunan Normal University. Hunan Children’s Hospital. Hunan University of Chinese Medicine. Hunan Province Key Laboratory of Vascular Biology and Translational

Regulatory B cells protect against chronic hypoxia-induced pulmonary hypertension by modulating the Tfh/Tfr immune balance Read More »

Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension

Mohammad Shafiq, Zahid Rasool Lone, Adam Olaitan Abdulkareem, Gurpreet Kaur, Sai Navya, Himalaya Singh, Kumaravelu Jagavelu, Kashif HanifCSIR-Central Drug Research Institute and Academy of Scientific and Innovative Research. Ann & Robert H. Lurie Children’s Hospital. University of Illorin.India and United States Pulmonary Pharmacology and TherapeuticsPulm Pharmacol Ther 2023; 80: DOI: 10.1016/j.pupt.2023.102200 AbstractEndothelial dysfunction is critical in

Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension Read More »

Sildenafil Improves Pulmonary Vascular Remodeling in a Rat Model of Persistent Pulmonary Hypertension of the Newborn

Lili Kang, Xianghong Liu, Zilong Li, Xiao Mei Li, Yujie Han, Chen Liu, Cuifen Zhao, Xiaoying LiQilu Children’s Hospital of ShanDong University. Qilu Hospital and Cheeloo College of MedicineChina Journal of Cardiovascular PharmacologyJ Cardiovasc Pharmacol 2023; 81: 232-239DOI: 10.1097/FJC.0000000000001373 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is characterized by pulmonary arterial remodeling mainly because of apoptosis

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Impaired cell-cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development

Debao Li, Jing Wang, Yuan Fang, Yuqing Hu, Yingying Xiao, Qing Cui, Chuan Jiang, Sijuan Sun, Hao Chen, Lincai Ye, Qi SunShanghai Children’s Medical Center. Shanghai Jiao Tong University. Shanghai Ninth People’s Hospital. China Respiratory ResearchRespir Res 2023; 24: DOI: 10.1186/s12931-023-02319-3 AbstractBackground: Pulmonary hypoperfusion is common in children with congenital heart diseases (CHDs) or pulmonary hypertension (PH)

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