Animal Models of Pulmonary Vascular Disease and Therapy

Celastrol has beneficial effects on pulmonary hypertension associated with bronchopulmonary dysplasia: Preclinical study outcomes

Claire-Marie Pilard, Guillaume Cardouat, Isabel Gauthereau, Laure Gassiat, Mathilde Dubois, Paul Robillard, Fanny Sauvestre, Fanny Pelluard, Sophie Berenguer, Melie Sarreau, Stéphane Claverol, Caroline Tokarski, Loïc Sentilhes, Frederic Coatleven, Marie Vincienne, Roger Marthan, Eric Dumas-de-la-Roque, Patrick Berger, Mark K. Friedberg, Laurent Renesme, Véronique Freund-Michel, Christelle GuibertUniversity of Bordeaux and Bordeaux University Hospital. Hospital for Sick Children […]

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Targeting Lung Heme Iron by Aerosol Hemopexin Administration in Sickle Cell Disease Pulmonary Hypertension

Melissa Lucero, Christina Lisk, Francesca Cendali, Delaney Swindle, Saini Setua, Kiruphagaran Thangaraju, David I. Pak, Quinton O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Nishant Rana, Saqib Khan, Natalie Westover, Pavel Davizon Castillo, Gemlyn George, Kathryn Hassel, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Andre F. Palmer, Angelo D’Alessandro, Paul W. Buelher, David C. IrwinUniversity of Colorado,

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Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation

Yanan Zhang, Xiaoyu Tiana, Liangyi Chenb, Shiqun Zhaob, Xinjing Tang, Xin Liu, Dan Zhou, Chaoshu Tang, Bin Geng, Junbao Dua, Hongfang Jina, Yaqian HuangPeking University First Hospital and Peking University. Wuhan Children’s Hospital. Fuwai Hospital and Peking Union Medical College. China Redox BiologyRedox Biol 2025; 80: DOI: 10.1016/j.redox.2025.103493 AbstractBackground: The binding of endothelin-1 (ET-1) to endothelin type

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Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential

Fabian Doktor, Lina Antounians, Rebeca Lopes Figueira, Kasra Khalaj, Miriam Duci, Augusto ZaniHospital for Sick Children and University of Toronto. Leipzig University.Canada and Germany Stem Cells Translational MedicineStem Cells Transl Med 2025; 14: DOI: 10.1093/stcltm/szae095 AbstractDisruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic

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Endothelial Cpt1a Inhibits Neonatal Hyperoxia-Induced Pulmonary Vascular Remodeling by Repressing Endothelial-Mesenchymal Transition

Xiaoyun Li, Katy Hegarty, Fanjie Lin, Jason L. Chang, Amro Abdalla, Karthik Dhanabalan, Sergey O. Solomevich, Wenliang Song, Karim Roder, Chenrui Yao, Wenju Lu, Peter Carmeliet, Gaurav Choudhary, Phyllis A. Dennery, and Hongwei YaoBrown University. Providence VA Medical Center. Warren Alpert Medical School of Brown University. Jinan University. First Affiliated Hospital of Guangzhou Medical University.

Endothelial Cpt1a Inhibits Neonatal Hyperoxia-Induced Pulmonary Vascular Remodeling by Repressing Endothelial-Mesenchymal Transition Read More »

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

Tsutomo Shinohara, Jan-Ranier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Divya Guntur, Shalina Taylor, Sarasa Isobe, Melody Dong, Weiguang Yang, Katherine Guo, Benjamin D. Franco, Cholawat Pacharinsak, Laura J. Pisani, Shinji Saitoh, Yoshihide Mitani, Alison L. Marsden, Jesse M. Engreitz, Jakob Körbelin, Marlene RabinovitchLucile

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LPS Increases Artery but Not Airway Contraction in Precision Cut Lung Slices from a Mouse Model of ARDS

Emma Lamanna, Zoe F. Kropf, Raymond Luong, Matthew Narayan, Elizabeth A. Richards, Bailey Cardwell, Simon G. Royce, Claudia A. Nold-Petry, Jane E. BourkeMonash University. RMIT University. Royal Melbourne Institute of Technology. Hudson Institute of Medical Research.Australia American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2024; DOI: 10.1165/rcmb.2024-0249OC AbstractAcute respiratory distress syndrome

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Cytochrome P450-derived Epoxyeicosatrienoic Acid, the Regulation of Cardiovascular-related Diseases, and the Implication for Pulmonary Hypertension

Run Lan, Meng-Jie Zhang, Ke Liu, Fang-Fang Meng, Xiao-He Xu, Chen-Chen Wang, Meng-Qi Zhang, Yi Yan, Jie-Jian Kou, Lu-Ling Zhao, Yang-Yang He, Hong-Da ZhangHuaihe Hospital and Henan University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital, National Center for Cardiovascular Diseases and Chinese Academy of

Cytochrome P450-derived Epoxyeicosatrienoic Acid, the Regulation of Cardiovascular-related Diseases, and the Implication for Pulmonary Hypertension Read More »

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle

Min Li, Brittany Alexandre McKeon, Sue Gu, Ram Raj Prasad, Hui Zhang, Sushil Kumar, Suzette Riddle, David C. Irwin, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus.United States International Journal of Molecular SciencesInt J Mol Sci 2024; 25: DOI: 10.3390/ijms252111600 AbstractPulmonary hypertension (PH) significantly impairs exercise capacity and the quality of life in patients, which is

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle Read More »

THBS1 mediates hypoxia driven EndMT in pulmonary hypertension

Bingming Peng, Yingzhen Zhou, Xingmeng Fu, Li Chen, Zhengxia Pan, Qijian Yi, Tengteng Zhao, Zhou Fu, Ting WangChildren’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders and Ministry of Education Key Laboratory of Child Development and Disorders. University of California, San Diego.China and United States Pulmonary CirculationPulm Circ 2024;

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