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The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway

Youpeng Jin, Fei Mao, Xuehui Wang, Jie Zhang, Yanting Gao, Youfei FanShandong Provincial Hospital, First Affiliated Hospital and Shandong First Medical University.China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-97627-7 AbstractPulmonary arterial hypertension (PAH) is a severe and progressive disease with hallmarks of pulmonary vascular remodeling and bone morphogenetic protein receptor 2 (BMPR2) mutation. Recent studies indicate […]

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Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome

Hendrik Schneider, Fabio Ius, Carsten Müller, Jawad Salman, Katharina Schütz, Harald Köditz, Katja, Nickel, Gesine Hansen, Dmitry Bobylev, Nicolaus, Schwerk, Julia CarlensHannover Medical School. Germany Journal of Heart and Lung TransplantationJ Heart Lung Transplant 2025; DOI: 10.1016/j.healun.2025.04.001 AbstractBackground: Childhood interstitial lung disease (chILD) is heterogeneous, associated with significant morbidity and can cause organ failure. In these cases,

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Pulmonary hypertension in pediatrics: from clinical suspicion to management

Julie Wacker, Maurice BeghettiGeneva University Hospitals. Switzerland European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06099-4 AbstractPediatric pulmonary hypertension differs from adult pulmonary hypertension in many ways, including multifactorial etiologies and comorbidities that can impact diagnosis, response to therapy, and outcome. The main etiologies of pediatric PH are idiopathic pulmonary arterial hypertension (PAH), PAH associated

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Risk stratification in Eisenmenger syndrome

Estibaliz Valdeolmillos, Athenaïs Boucly, Marc Humbert, Olivier Sitbon, Laurent Savale, David Montani, Jérôme Le Pavec, Elie Fadel, Magalie Ladouceur, Emmanuelle Fournier, Gregoire Albenque, Bastien Provost, Clément Batteux, Alain Fraisse, Michael A. Gatzoulis, Aleksander Kempny, Sebastien HascoëtHôpital Marie Lannelongue, les hôpitaux Paris Saint-Joseph et Marie Lannelongue and Université Paris-Saclay. Hôpitaux Universitaires de Genève. Royal Brompton Hospital.

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Konar-MF™: Versatile Utility Suggests Potential to Simplify Congenital Catheterization Laboratory Inventory

Navaneetha Sasikumar, Pranoti Toshniwal. Usha Mandikal Kondakarna Sastry, Shweta Bakhru, Jayaranganath Mahimarangaiah, Nageshwara Rao Koneti, Raman Krishna KumarAmrita Institute of Medical Sciences. Sri Jayadeva Institute of Cardiovascular Sciences and Research. Rainbow Children’s Hospital.India Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-03849-x AbstractKONAR-MF™ device is a novel, cone-shaped, medium profile, self-expanding, double-disk, nitinol occlusive device designed for the ventricular

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Editorial on “Elective Thoracic Surgical Resections for Pulmonary Arteriovenous Malformations-A 16 Year Single-Center Experience”

Raghav MurthyMedical City Children’s HospitalUnited States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70073 AbstractAbstract Not Available CategoryPulmonary Arteriovenous MalformationsSurgical and Catheter-mediated Interventions for Pulmonary Vascular Disease Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access Free PDF File or Full Text Article Available Through PubMed

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miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6

Yingjie Wang, Le Sun, Xianxian Jia, Miao Yang, Wei XuShengjing Hospital of China Medical University.China FASEB JournalFASEB J 2025; 39:DOI: 10.1096/fj.202401069RRR AbstractPulmonary hypertension of the newborn (PHN) is a common pulmonary vascular disease in newborns, affecting the prognosis of affected infants and even leading to death. Currently, there is still no specific targeted prevention and treatment

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Shedding Light on the Dark Side of the Moon-Understanding Pediatric Right Ventricular Work in Pulmonary Hypertension

Taylor P. Saley, Ryan D. ColemanBaylor College of Medicine.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70070 AbstractAbstract Not Available CategoryRight Heart Dysfunction Associated with Pulmonary Vascular DiseaseDiagnostic Testing for Pulmonary Vascular Disease. Non-invasive Testing Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access Free

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Neurodevelopmental outcomes at age 5 years among children born very preterm and surviving after persistent pulmonary hypertension of the newborn: EPIPAGE-2 cohort study

Sophie Breinig, Virginie Ehlinger, Jean-Christophe Rozé, Laurent Storme, Xavier Durrmeyer, Gilles Cambonie, Lionel Berthomieu, Valérie Benhammou, Geraldine Gascoin, Pierre-Yves Ancel, Catherine ArnaudChildren’s Hospital, Toulouse University Hospital and Toulouse University. Nantes University Hospital. Lille University Hospital. CHI Créteil. Montpellier University Hospital. France European Journal of Paediatric NeurologyEur J Paediatr Neurol 2025; 55: 103-110DOI: 10.1016/j.ejpn.2025.03.007 AbstractObjective: To determine whether

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Virtual reality modelling based on computed tomography and three-dimensional angiography for planning of percutaneous and hybrid treatment in infants with pulmonary vein stenosis

Judyta Szeliga, Małgorzata Waśko, Jacek Kołcz, Andrzej Rudziński, Ryan Callahan, Sebastian GórecznyUniversity Children’s Hospital and Jagiellonian University Medical College. Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania.Poland and United States Advances in Interventional CardiologyAdv Interv Cardiol (Postepy Kardiol Interwencyjnej) 2025; 21: 108-113DOI: 10.5114/aic.2025.147992 AbstractAbstract Not Available CategorySegmental Pulmonary Venous Disease.

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