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Cx43 mediates nicotine-induced enhancement of mouse pulmonary arterial tone by downregulating Kv1.2 and Kv2.1 channels

Xiaomin Hou, Xuelu Jiang, Xin Meng, Jin Zhou, Di Xi, Xiaoxia Ren, Ming Gao, Yong’e Liu, Xiao Luo Yiwei Shi, Xiaojiang QinShanxi Medical University. China-Japan Friendship Hospital. Shanxi Coal Central Hospital. First hospital of Shanxi Medical University. China Food and Chemical ToxicologyFood Chem Toxicol 2026; DOI: 10.1016/j.fct.2026.116182 AbstractPulmonary hypertension (PH) is a chronic and complex condition […]

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Child Opportunity Index Influences Pediatric Pulmonary Hypertension Outcomes: Analyses From the Pediatric Health Information System

Jai K. Khurana, Stuart Lipsitz, Diana L. Geisser, Katie M. Moynihan, Mary P. MullenBoston Children’s Hospital and Harvard Medical School.United States Journal of the American College of Cardiology AdvancesJACC Adv 2026; 5: DOI: 10.1016/j.jacadv.2026.102773 AbstractBackground: Social determinants of health (SDoH) in pediatric pulmonary hypertension (PH) outcomes are inadequately characterized.Objectives: The authors examined associations between SDoH and pediatric PH

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Clinical Utility and Limitations of TAPSE in Pediatric Echocardiography: A Narrative Review

Matei Mselle, Ronald MbwasiHaydom Lutheran Hospital. Kilimanjaro Christian Medical Centre and Kilimanjaro Christian Medical University.Tanzania EchocardiographyEchocardiography 2026; 43: DOI: 10.1111/echo.70516 AbstractBackground: Tricuspid annular plane systolic excursion (TAPSE) is widely used to assess right ventricular (RV) longitudinal systolic function in pediatric echocardiography; however, its reliability is influenced by developmental physiology.Objective: To evaluate the clinical utility, age-dependent variability, and limitations

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Prenatal Assessment of Diaphragmatic Defect Size in Left-Sided Congenital Diaphragmatic Hernia Using a Novel MRI-based Parameter for Outcome Prediction: The Defect-to-HEmithorax Ratio (DHER)

Chiara Panunzi, Sara Savelli, Laura Valfré, Irma Capolupo, Milena Viggiano, Chiara Vassallo, Andrea Conforti, Leonardo Caforio, Isabella FabiettiBambino Gesù Children’s Hospital, IRCCS and Università degli Studi di Pavia. Italy American Journal of Obstetrics and Gynecology Maternal Fetal MedicineAm J Obstet Gynecol MFM 2026; DOI: 10.1016/j.ajogmf.2026.102002 AbstractBackground: In congenital diaphragmatic hernia (CDH), the size of the diaphragmatic defect

Prenatal Assessment of Diaphragmatic Defect Size in Left-Sided Congenital Diaphragmatic Hernia Using a Novel MRI-based Parameter for Outcome Prediction: The Defect-to-HEmithorax Ratio (DHER) Read More »

A Life Without Lemons: A Case of Severe Pulmonary Arterial Hypertension Secondary to Vitamin C Deficiency in a Child With Autism Spectrum Disorder

Beau Redwood, Simon Erickson, Lily Loughman, Zoe VettenPerth Children’s Hospital. Genetic Services of Western Australia.Australia Journal of Pediatrics and Child HealthJ Pediatr Child Health 2026; DOI: 10.1111/jpc.70448 AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other DisordersMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh

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Registry-based estimation of cardiac event-free survival in congenital heart disease complicated by pulmonary hypertension: A nationwide registry study from Japan

Taku Ishii, Tatsuhiko Anzai, Keiko Uchida, Susumu Hosokawa, Naofumi F. Sumitomo, Hidekazu Ishida, Keiichi Hirono, Jun Muneuchi, Ayako Chida-Nagai, Ryo Inuzuka, Hirofumi Sawada, Sayo Suzuki, Jun Maeda, Hisaaki Aoki, Lisheng Lin, Takashi Murakami, Yusuke Nakano, Tatsuya Onishi, Takuya Wakamiya, Kei Inai, Shinichi Takatsuki, Atsushi Yao, Shigetoyo Kogaki, Hiroyuki Fukushima, Yuichi Tamura, Kunihiko Takahashi, Hiroyuki Yamagishi,

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ABO Incongruency Increases Risk for Necrotizing Enterocolitis in Preterm Neonates

Jeremy A. Sandgren, Numra A. Aleem, J. Brooks Jackson, Jennifer R. Bermick, Timothy J. BolyUniversity of Iowa.United States Transfusion Medicine and HemotherapyTranfus Med Hemother 2026; DOI: 10.1159/000551548 AbstractIntroduction: Preterm neonates are at high risk for complications, and inflammation has been implicated in many of these pathologies. ABO incongruency occurs when the maternal and neonatal blood types are

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Association between upper airway obstruction and pulmonary hypertension in children with Down syndrome

Kevin Guy, Amal IsaiahUniversity of Maryland School of Medicine.United States Current Opinion in Pulmonary MedicineCurr Opin Pulm Med 2026; DOI: 10.1097/MCP.0000000000001287 AbstractPurpose of review: Down syndrome (DS) is the most common nonlethal chromosomal aneuploidy, affecting 1 in 700 live births. Pulmonary hypertension (PH) occurs in approximately 25% of children with DS and contributes to a 10% mortality

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A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo Heterozygous CAV1 Mutation in a Pediatric Patient

Yan Sun, Qingyou Zhang, Yaqian Huang, Xueqin LiuPeking University First Hospital.China ChildrenChildren 2026; 13: DOI: 10.3390/children13050694 AbstractBackground: Pulmonary arterial hypertension is a rare but life-threatening condition in children, with hereditary forms often being linked to mutations in genes such as bone morphogenetic protein receptor type 2 (BMPR2), caveolin 1 (CAV1), and potassium channel subfamily K member

A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo Heterozygous CAV1 Mutation in a Pediatric Patient Read More »

Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models

Siqi She, Debao Li, Qi Sun, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China ChildrenChildren 2026; 13: DOI: 10.3390/children13050677 AbstractPulmonary vein stenosis (PVS) is a rare and devastating condition affecting infants and children, characterized by progressive intimal hyperplasia, myofibroblast proliferation,

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