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Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu ZhouSeventh Medical Center of the PLA General Hospital. Southern Medical University. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02945-5 AbstractBackground: Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev […]

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Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Shuibang Wang, Keytam S. Awad, Li-Yuan Chen, Mohammad A. H. Siddique, Gabriela A. Ferreyra, Caroline L. Wang. Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, You-Yang Zhao, Jason M. Elinoff, Robert L. DannerNational Institutes of Health Clinical Center. National Heart Lung and Blood Institute. Northwestern University.United States American Journal of Physiology Lung Cellular and

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α Read More »

In situ relief of postrepair pulmonary venous obstruction using the endocardial anchoring technique

Yusuke Yamamoto, Sho Akiyama, Kentaro Hotoda, Mio Noma, Shuhei Yamaguchi, Hiroki Nagamine, Jun Maeda, Yukihiro YoshimuraTokyo Metropolitan Children’s Medical Center. Japan Journal of Thoracic and Cardiovascular Surgery TechniquesJTCVS Tech 2024; 26: 96-99DOI: 10.1016/j.xjtc.2024.04.009 AbstractOutcomes of the conventional repair for total anomalous pulmonary venous return (TAPVR) remain suboptimal mainly due to the occurrence of progressive pulmonary venous

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Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models

Megan Griffiths, Catherine E. Simpson, Jun Yang, Dhananjay Vaidya, Melanie K. Nies, Stephanie Brandal, Rachel Damico, Paul Hassoun, D. Dunbar Ivy, Eric D. Austin, Michael W. Pauciulo, Katie A. Lutz, Lisa J. Martin, Erika B. Rosenzweig, Raymond L. Benza, William C. Nichols, Cedric Manlhiot, Allen D. EverettJohns Hopkins University. University of Texas Southwestern. Children’s Hospital

Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models Read More »

An Interdisciplinary Consensus Approach to Pulmonary Hypertension in Developmental Lung Disorders

Nidhy P. Varghese, Eric D. Austin, Csaba Galambos, Mary P. Mullen, Delphine Yung, R. Paul Guillerman, Sara O. Vargas, Catherine M. Avitabile, Corey A. Chartan, Nahir Cortes-Santiago, Michaela Ibach, Emma O. Jackson, Jill Ann Jarrell, Roberta L. Keller, Usha S. Krishnan, Kalyani R. Patel, Jennifer Pogoriler, Elise C. Whalen, Kathryn Wikenheiser-Brokamp, Natalie M. Villafranco, Steven

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MR Lymphangiography: Congenital Lymphatic Flow Disorders

Seunghyun Lee, Saebeom Hur, Young Hun Choi, Jae-Yeon Hwang, Jung-Eun CheonSeoul National University Hospital and College of Medicine.Republic of Korea Investigative RadiologyInvest Radiol 2024; DOI: 10.1097/RLI.0000000000001112 AbstractCongenital lymphatic flow disorders collectively refer to a heterogeneous group of diseases that manifest as chylothorax, chylous ascites, intestinal lymphangiectasia, protein-losing enteropathy, and peripheral extremity or genital lymphedema, all in

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Lymphatic Imaging and Intervention in Congenital Heart Disease

Christoph Bauer, Mario Scala, Jonathan J. Rome, Gerald Tulzer, Yoav DoriKepler University Hospital and Johannes Kepler University Linz. Children’s Hospital of Philadelphia.Austria and United States Journal of the Society for Cardiovascular Angiography and InterventionsJ Soc Cardiovasc Angiogr Interv 2024; 3:DOI: 10.1016/j.jscai.2023.101174 AbstractThe lymphatic system plays a central role in some of the most devastating complications associated

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Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations

Elijah H. Bolin, Peter M. Mourani, Staphanie D. Byrum, Samuel G. Mackintosh, Amy M. Dossey, Michael J. Angtuaco, Dala Zakaria, Lawrence E. Greiten. Graham M. Strub, Haihong Zhang, Gresham T. RichterUniversity of Arkansas for Medical Sciences and Arkansas Children’s Research Institute. United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03450-7 AbstractApproximately 1000 children are born every year

Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations Read More »

Pediatric hemoptysis: diagnostic and interventional challenges

Anisha Garg, Ashu Bhalla, Priyanka Naranje, Devasenathipathy KandasamyAll India Institute of Medical SciencesIndia Pediatric RadiologyPediatr Radiol 2024; DOI: 10.1007/s00247-024-06002-7 AbstractHemoptysis in the pediatric population, while infrequent, poses significant challenges for both the family and healthcare practitioners. The severity of hemoptysis dictates management decisions. Most cases being mild and self-limiting are treated conservatively. However, “life-threatening hemoptysis” may

Pediatric hemoptysis: diagnostic and interventional challenges Read More »

Right pulmonary artery originating from the ascending aorta with tetralogy of fallot and pulmonary atresia

Filippos-Paschalis Rorris, Meletios Kanakis, George Samanidis, Alexandros Tsoutsinos, Achilleas Lioulias, Dimitrios BobosOnassis Cardiac Surgery Centre.Greece Clinical Case ReportsClin Case Rep 2024; 12: DOI: 10.1002/ccr3.9232 AbstractAnomalous pulmonary artery originating from the ascending aorta (often called hemitruncus) is a rare congenital cardiac defect requiring immediate management in the neonatal period. We report a case of a rare variant of anomalous right pulmonary artery originating

Right pulmonary artery originating from the ascending aorta with tetralogy of fallot and pulmonary atresia Read More »

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