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Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in Down syndrome

Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy DelaneyUniversity of Colorado Anschutz. United States Frontiers in ImmunologyFront Immunol 2026; DOI: 10.3389/fimmu.2026.1832057 AbstractTrisomy 21 (T21) results in Down syndrome (DS), a condition associated

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Anomalous origin of the right pulmonary artery from the ascending aorta: a case report and review of the literature

Alwaleed Al-Dairy, Ali Deeb, Zakaria Aldammad, Ahmad Al-BitarDamascus University. Syrian Arab Republic (Syria) International Journal of Surgery Case ReportsInt J Surg Case Rep 2026; 138: 2278-2282DOI: 10.1097/RC9.0000000000000526 AbstractIntroduction: Anomalous aortic origin of a pulmonary artery (AORPA), or hemitruncus arteriosus, is a rare congenital anomaly in which one pulmonary artery arises directly from the ascending aorta. Without timely

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From case reports to a cohort: illuminating the spectrum of pulmonary hypertension in Noonan syndrome

Jonah D. Garry, D. Dunbar Ivy, Eric D. AustinVanderbilt University Medical Center. University of Colorado School of Medicine. United States European Respiratory JournalEur Respir J 2026; 67: DOI: 10.1183/13993003.00064-2026 AbstractAbstract Not Available CategoryGenetic Factors Associated with Pulmonary Vascular Disease Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since

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Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with

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Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

M. Elizabeth Moss, Timothy Klouda, Yan Li, Yu Liu, Meng Tan, Yunhye Kim, Yuan Hao, Mark R. Nicolls, Joseph C. Wu, Richard Bucala, Hong Chen, Eungjoo Lee, Karin Tran-Lundmark, Benjamin Raby, Ke YuanBoston Children’s Hospital and Harvard Medical School. Stanford University. University of California, San Diego. Yale School of Medicine. University of Arizona. Lund University

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Cryptogenic Young Stroke Associated With Bilateral Pulmonary Arteriovenous Malformations

Naimisha Yenduri, Hisham Ahamed, Vivek Nambiar, Navaneetha SasikumarAmrita Institute of Medical Sciences. India Heart Lung and CirculationHeart Lung Circ 2026; DOI: 10.1016/j.hlc.2026.02.007 AbstractAbstract Not Available CategoryPulmonary Arteriovenous MalformationsSymptoms and Findings Associated with Pulmonary Vascular Disease Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access Free

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Pediatric heart failure: A focus on low-income countries

Sulafa Km AliUniversity of Sharjah.United Arab Emirates World Journal of Clinical PediatricsWorld J Clin Pediatr 2026; 15: DOI: 10.5409/wjcp.v15.i2.115168 AbstractHeart failure (HF) in the pediatric population is unique because it involves heterogeneous groups of diseases, including congenital and acquired conditions. The etiology of HF varies with age and sociodemographic origin. In low-income countries, unoperated congenital heart

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[Pulmonary Arterial Hypertension Impairs Duodenal Barrier Integrity in Rats]

Shouei Ishimaru, Satoshi Mizuno, Tomoya Tanada, Daisuke Saito, Keiichi Hirono, Keijiro Ibuki, Masato TaguchiUniversity of Toyama.Japan Yakugaku Zasshi (Journal of the Pharmaceutical Society of Japan)Yakugaku Zasshi 2026; DOI: 10.1248/yakushi.25-00165 AbstractPulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that leads to right heart failure and systemic venous congestion. Such congestion can impair multiple organs, including

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Risk Stratification and Fetal Therapies for Congenital Diaphragmatic Hernia

Connor V. Haynes, David H. StitelmanYale New Haven Children’s Hospital,United States NeoreviewsNeoreviews 2026; DOI: 10.1542/neo.27-6-021 AbstractCongenital diaphragmatic hernia (CDH) remains one of the most challenging congenital anomalies encountered by neonatologists and pediatric surgeons, with outcomes largely determined before birth. Although surgical repair of the diaphragmatic defect is essential, postnatal morbidity and mortality are primarily driven by

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Breathing challenges in achondroplasia: a comprehensive review of pediatric respiratory complications

Veronica Fasoli, Alessia Mariani, Federica Chironi, Mara Lelii, Barbara Madini, Beatrice Andrenacci, Alessia Rocchi, M. Francesca Bedeschi, M. Gaffuri, M. Pluderi, M. Francesca PatriaUniversità Degli Studi di Milano. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Italy Paediatric Respiratory ReviewsPaediatr Respir Rev 2026; DOI: 10.1016/j.prrv.2026.05.003 AbstractAchondroplasia is the most common skeletal dysplasia, characterized by disproportionate short stature

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