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Novel scoring tool of hypoxemic respiratory failure and pulmonary hypertension for defining severity of persistent pulmonary hypertension of newborn

Sage Timberline, Avni Bhatt, Sherzana Sunderji, Daniel J. Tancredi, Satyan Lakshminrusimha, Heather SiefkesUniversity of Virginia. University of California, Davis. United States Journal of PerinatologyJ Perinatol 2023; DOI: 10.1038/s41372-023-01762-w AbstractObjective: To obtain preliminary validity data for a hypoxemic respiratory failure/pulmonary hypertension (HRF/PH) score for classifying persistent pulmonary hypertension of the newborn (PPHN).Study design: Retrospective chart review of 100 consecutive […]

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Efficacy of Sildenafil in Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

Kacie Dillon, Vineet Lamba, Ranjit R. Philip, Mark F. Weems, Ajay J. Talati University of Tennessee Health Science Center.United States ChildrenChildren 2023; DOI: 10.3390/children10081397 AbstractBackground: Pulmonary hypertension (PH) is a common comorbidity in infants with bronchopulmonary dysplasia (BPD). Sildenafil is a widely recognized therapy for PH, but its efficacy in infants with BPD is questionable. We propose

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Outcomes of pregnancy in mice with pulmonary hypertension induced by Hypoxia/SU5416

Yang Liu, Jing Deng, Yichen Zhao, Kemin Liu, Wenbo Zhang, Qiang Wang, Jiangang Wang, Chunmei PiaoBeijing Anzhen Hospital Affiliated to Capital Medical University. Yanbian University. Beijing Institute of Heart Lung and Blood Vessel Diseases. China Biochemical and Biophysical Research CommunicationsBiochem Biophys Res Commun 2023; 669: 128-133DOI: 10.1016/j.bbrc.2023.05.051 AbstractBackground: Pulmonary hypertension (PH) seriously affects the health of patients.

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Infantile hemangiomatosis, a rare cause of high-output heart failure and pulmonary hypertension in the newborn baby: a case report

Nurdan Erol, Abdullah Alpinar, Nihan Uygur KulcuHealth Sciences University Zeynep Kamil Women and Children Diseases Training and Research Hospital.Turkey Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123001488 AbstractInfantile hemangiomatosis is among the most common vascular tumours of childhood that is generally accepted as benign. Some cases may have multiple hemangiomas with organ involvement, especially of the

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Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries

Yan Bai, Guang Li, Laiming Yung, Paul B. Yu, Xingbin AiMassachusetts General Hospital and Harvard Medical School. Brigham and Women’s Hospital. Renmin Hospital and Wuhan University. United States and China American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L114-L124DOI: 10.1152/ajplung.00293.2022 AbstractIntrapulmonary arteries located in the proximal lung

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Sedation Prior to Intubation at Birth in Infants with Congenital Diaphragmatic Hernia: An International Survey on Current Practices

Emily J. J. Horn-Oudshoorn, Alisa M. Blekherov, Gerbrich E. van den Bosch, Sinno H. P. Simons, Ronny Knol, Arjan B. te Pas, Irwin K. M. Reiss, Philip L. J. DeKoninckErasmus MC University Medical Center. Leiden University Medical Center. Netherlands NeonatologyNeonatology 2023; 120: 434-440DOI: 10.1159/000530573 AbstractIntroduction: Infants with congenital diaphragmatic hernia (CDH) are commonly intubated immediately after birth.

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Surgical treatment of anomalous right upper lobe pulmonary vein obstruction caused by compression between pulmonary artery and trachea: a case report

Benqung Zhang, Jianming Xia, Xiaoqi WangFuwai Yunnan Cardiovascular Hospital. Chinese Academy of Medical Sciences and Peking Union Medical College. China Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123002494 AbstractThe normal anatomical course of right upper lobe pulmonary vein involves drainage anteriorly to the pulmonary artery, ultimately reaching the left atrium. However, anomalies can occur with the

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Unique Pulmonary Hypertensive Vascular Diseases Associated with Heart and Lung Developmental Defects

Hidekazu Ishida, Jun Maeda, Keiko Uchida, Hiroyuki YamagishiOsaka University Graduate School of Medicine. Tokyo Metropolitan Children’s Medical Center. Keio University of Medicine and Health Center.Japan Journal of Cardiovascular Development and DiseaseJ Cardiovasc Dev Dis 2023; DOI: 10.3390/jcdd10080333 AbstractAlthough pediatric pulmonary hypertension (PH) shares features and mechanisms with adult PH, there are also some significant differences between

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Muscle strength is reduced in children with pulmonary arterial hypertension

Shari Pepplinkhuizen, Graziella Eshuis, Willemijn M. H. Zijlstra, Carola Y. Timmer, Mark Jan Ploegstra, Otto T. H. M. Lelieveld, Ann Marjolein Hepping, Ernesto A. C. Beenakker, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Roessingh Center for Rehabilitation Enschede. Medical Center Leeuwarden.Netherlands Pulmonary CirculationPulm Circ 2023; 13DOI: 10.1002/pul2.12246 AbstractMuscle strength

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MicroRNA and lncRNA as the Future of Pulmonary Arterial Hypertension Treatment

Łukasz Wołowiec, Martyna Medlewska, Joanna Osiak, Anna Wołowiec, Elzbieta Grzésk3 , Albert Jásniak, Grzegorz GrzéskNicolaus Copernicus University.Poland International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24119735 AbstractPulmonary hypertension (PH) is characterized by a progressive increase in pulmonary arterial pressure and pulmonary vascular resistance. In a short time, it leads to right ventricular failure

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