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Novel echocardiographic markers for the assessment of pulmonary hypertension in infants

Sarah Diamond, Beverly Spray, Amna Qasim, Peter M. Mourani, Amit Agarwal, Michael Angtuaco, Ankita Shukla, Richard W. Hall, Megha SharmaUniversity of Arkansas for Medical Sciences and Arkansas Children’s Research Institute. University of Michigan. Baylor College of Medicine. United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02748-0 AbstractPulmonary hypertension (PH) confers significant morbidity and mortality in infants. […]

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Phenotype-based screening algorithm for chronic pulmonary hypertension in preterm infants with bronchopulmonary dysplasia

Sarah E. Diamond, Amy H. Stanford, Adrianne R. Bischoff, Patrick J. McNamara, Philip T. LevyUniversity of Arkansas for Medical Sciences and Arkansas Children’s Hospital. University of Iowa. Boston Children’s Hospital and Harvard Medical School. United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02776-w AbstractChronic pulmonary hypertension (cPH) associated with bronchopulmonary dysplasia (BPD) remains a major contributor

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Alveolar capillary dysplasia with misalignment of pulmonary veins in neonates: a multicenter cohort study

Prithvi Sendi, Paul Martinez, Kaitlin Kobaitri, Balagangadhar R. TotapallyNicklaus Children’s Hospital. Herbert Wertheim College of Medicine and Florida International University.United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05265-0 AbstractBackground: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare developmental lung disorder associated with high neonatal mortality. We aimed to describe the epidemiology, resource utilization, and

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Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation

Weidi Xiao, Nedaa Aldairi, Brian S. Marcus, Matthew Weiss, Allison S. Cowl, Marissa Moncata, Akash Deep, Oliver KaramYale University, Yale New Haven Children’s Hospital and Yale School of Medicine. Dr. Sulaiman AlHabib Medical Group. Albert Einstein College of Medicine. Centre Mère-Enfant Soleil du CHU de Québec. Connecticut Children’s Medical Center. King’s College Hospital. United States,

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Cardiac performance and left ventricular dimensions in neonates with left-sided congenital diaphragmatic hernia before and after surgical repair

Mohamed Mahmoud Shalaby, Fatma Aboalsoud TahaTanta University.Egypt Journal of Cardiothoracic SurgeryJ Cardiothorac Surg 2026; DOI: 10.1186/s13019-026-04289-1 AbstractBackground: Congenital Diaphragmatic Hernia (CDH) is associated with significant cardiopulmonary morbidity. Pulmonary Hypertension (PH) and left ventricular (LV) dysfunction are major determinants of outcome. While the impact of CDH repair on pulmonary hemodynamics is recognized, comprehensive serial assessment of cardiac performance,

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Diffusion of carbon monoxide in the lungs and pulmonary artery pressures in school aged children who were born preterm

Christopher Harris, Allan Jenkinson, Sanja Zivanovic, Kuberan Pushparajah, Theodore Dassios, Steven H. Abman, Anne GreenoughKing’s College London, King’s College Hospital NHS Foundation Trust and Imperial College Healthcare NHS Trust. University of Colorado School of Medicine.united Kingdom and United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05260-5 AbstractBackground: Premature birth is associated with altered pulmonary vascular development and raised

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SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension

Xiao-He Xu, Yi Shen, Min Chen, Yu-Xin Miao, Lin Cheng, Yang-Han-Yue Zhao, Yang Fang, Dai-Ji Jiang, Fang Yu, Yang-Yang He, Zhuo-Yuan Xu, Li-Jun Fu, Li-Wei Wu, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Henan University. Second Affiliated Hospital, Yuying Children’s Hospital, Wenzhou Medical

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Cardiac Index Measured Using the Fick Principle Versus Thermodilution in Children Following Orthotopic Heart Transplantation

Elyssa Cohen, Conor O’Halloran, Nicholas Pilli, Paul TannousAnn and Robert H. Lurie Children’s Hospital of Chicago.United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04302-3 AbstractCardiac index (CI) is used to assess graft function and calculate pulmonary vascular resistance (PVR) following orthotopic heart transplantation (OHT). The gold standard is thermodilution (TD), but in practice, the Fick method using

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Off-Label Sotatercept Use in Pediatric Pulmonary Arterial Hypertension: A Single-Center Retrospective Hemodynamic Study

Dhruv Rao, Shylah Haldeman, Jeanne Carroll, Rohit RaoUniversity of Arizona, Tucson. Rady Children’s Hospital-San Diego and University of California San DiegoUnited States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04349-2 AbstractSotatercept, a first-in-class activin signaling inhibitor, has demonstrated disease-modifying efficacy in adults with pulmonary arterial hypertension (PAH). Pediatric data remain limited to ongoing clinical trials. We conducted an

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L-Citrulline: Novel Pharmacotherapy to Improve Outcomes in Infants and Children at Risk of Systemic or Pulmonary Vascular Disease

Candice D. Fike, Frederick E. Barr, Judy L. AschnerUniversity of Utah Health. Diversified Search Group. Hackensack Meridian School of Medicine.United States PharmaceuticalsPharmaceuticals 2026; 19: DOI: 10.3390/ph19060896 AbstractInfants and children suffering from a variety of heart, lung, and blood disorders are known to be at risk of developing systemic or pulmonary vascular disease. Despite progress made in

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