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Web server-based deep learning-driven predictive models for respiratory toxicity of environmental chemicals: Mechanistic insights and interpretability

Na Li, Zhaoyang Chen, Wenhui Zhang, Yan Li, Xin Huang, Xiao LiFirst Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital. China Journal of Hazardous MaterialsJ Hazard Mater 2025; 489: DOI: 10.1016/j.jhazmat.2025.137575 AbstractRespiratory toxicity of chemicals is a common clinical and environmental health concern. Currently, most in silico prediction models for chemical respiratory […]

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An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension

Ram Raj Prasad 1, Sushil Kumar 1, Hui Zhang 1, Min Li 1, Cheng-Jun Hu 2, Suzette Riddle 1, Brittany A McKeon 3, M G Frid 1, Konrad Hoetzenecker 4, Slaven Crnkovic 5, Grazyna Kwapiszewska 5, Rubin M Tuder 1, Kurt R Stenmark 1 University of Colorado Anschutz Medical Campus. Medical University of Vienna. Medical University of Graz.United States and Austria Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.184141 AbstractThe complement system is central to the innate immune response, playing

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Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension: a case series

Aster De Vadder, Lotte Lemloh, Bartolomeo Bo, Lennart Hale, Neil Patel, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn. Royal Hospital for Children. Germany and United Kingdom European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06019-6 AbstractCongenital diaphragmatic hernia (CDH)-associated pulmonary hypertension (PH) is associated with high morbidity and mortality. Pulmonary vasodilative management is challenging

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Modifiable and Non-Modifiable Risk Factors for Tracheostomy in Preterm Infants

Brandon Dudeck, Elias W. Abebe, Wendy Sun, Peter R. Gaskin, Rose M. Viscardi, Eunsung ChoUniversity of Maryland School of Medicine. Wellspan York Hospital. Los Angeles Mattel Children’s Hospital and University of California, Los Angeles.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71005 AbstractObjective: To identify risk factors for tracheostomy among infants born < 33 week gestational age.Methods: We

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Risk Factors Associated With the Development of Late Pulmonary Artery Hypertension in Extremely Premature Infants

Paige E. Condit, JohnS. Hokanson Vivek Balasubramaniam, David J. McCulley, Michael Lasarev, Luke Lamers, Ryan M. McAdams, Dinushan C. KaluarachchiUniversity of Wisconsin School of Medicine and Public Health. University of California, San Diego. United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.27501 AbstractObjective: To identify risk factors for late pulmonary artery hypertension (PH) at 36 weeks’ postmenstrual

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Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Manivannan Yegambaram, Anlin Feng, Yishu Dong, Saurabh Aggarwal, Hoshang J. Unwalla, Jeffrey R. Fineman, Stephen M. Black, Ting WangFlorida International University. University of California, San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26031352 AbstractPulmonary arterial hypertension (PAH) is characterized by increased lung

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Severe pulmonary hypertension in a small-for-date neonate with skeletal dysplasia

Khuloud Mohamed, Mohammad A. A. Bayoumi, Muhammed Riyas Rahmath, Einas Elzubier ElmalikHamad Medical CorporationQatar British Medical Journals Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2024-264256 AbstractAbstract Not Available CategoryClass III. Pulmonary Hypertension Associated with Lung Hypoplasia Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access

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Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score

Vladimir L. Cousin, Caroline Caula, Jason Vignot, Raphael Joye, Matthieu Blanc, Clémence Marais, Pierre TissièresAP-HP Paris Saclay University, Bicêtre Hospital. Evelina London Children’s Hospital. Geneva University Hospital. Hospital for Sick Children and University of Toronto. France, United Kingdom, Switzerland and Canada Critical CareCrit Care 2025; 29: DOI: 10.1186/s13054-025-05300-2 AbstractBackground: Despite widespread vaccination programs, pertussis continues circulating within

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Physical Activity Measured by Hip-Anchored Accelerometry in Pediatric Pulmonary Hypertension: Association with Disease Severity & Estimation of Minimal Important Differences

Mark-Jan Ploegstra, Rosaria J. Ferreira, Chantal Lokhorst, Eva Gouwy, Suzanne S. J. Schwartz, Marlies G. Haarman, Matthieu Villeneuve, Dimitri Stamatiadis, Johannes M. Douwes, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen andUniversity of Groningen. Actelion Pharmaceuticals.Netherlands and Switzerland ChestChest 2025; DOI: 10.1016/j.chest.2025.01.038 AbstractBackground: Pediatric pulmonary hypertension (PH) is a severe incurable disease with poor prognosis.

Physical Activity Measured by Hip-Anchored Accelerometry in Pediatric Pulmonary Hypertension: Association with Disease Severity & Estimation of Minimal Important Differences Read More »

A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension

Lan Zhao, Christine M. Cunningham, Jason Hong, Stuti Agarwal, Ke Yuan, Vinicio A. de Jesus Perez, Mark R. NicollsStanford University. University of California, Los Angeles. Boston Children’s Hospital.United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0410OC AbstractPulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular

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