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Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study

Kevin R. Barker, Andrea L. Conroy, Michael Hawkes, Holly Murphy, Prativa Pandey, Kevin C. KainUniversity of Toronto and University Health Network-Toronto General Hospital. University of Alberta. CIWEC Hospital and Travel Medicine Center. Canada and Nepal Journal of Travel MedicineJ Travel Med 2016; 23: DOI: 10.1093/jtm/taw005 AbstractBackground: The mechanisms underlying acute mountain sickness (AMS) and high-altitude pulmonary edema […]

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Six cases of ENPP1 pathogenic variants causing autosomal recessive hypophosphatemic rickets type 2 and generalized arterial calcification of infancy

Lucy Collins, Jessica Sandy, Stephanie Ly, Kate E. Lomax, Sarah Black, Fiona McKenzie, Eadaoin Hayes, Cathryn Poulton, Craig Jefferies, Wendy Hunter, Peter Simm, Christine Rodda, Andrew Biggin, Craig Munns, Aris SiafarikasRoyal Children’s Hospital. Monash University. Children’s Hospital at Westmead. University of Sydney. Perth Children’s Hospital. University of Western Australia. King Edward Memorial Hospital. Starship Children’s

Six cases of ENPP1 pathogenic variants causing autosomal recessive hypophosphatemic rickets type 2 and generalized arterial calcification of infancy Read More »

Exploring new heights with pulmonary functional imaging: insights into high-altitude pulmonary edema

Sean B. Fain, Marlowe W. EldridgeUniversity of Wisconsin-Madison Medical School.United States Journal of Applied PhysiologyJ Appl Physiol 2017; 122: 853-854DOI: 10.1152/japplphysiol.00168.2017 AbstractAbstract Not Available CategoryHigh Altitude Pulmonary Edema Age Focus: Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication Article Access Free PDF File

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Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

Claudia Mickael, Jane C. Kabwe, Dara Fonseca Balladares, Annika S. Bai, Kevin Nolan, Michael H. Lee, Rahul Kumar, Joan F. Hilton, Joseph Phiri, Taonga Musonda, Katie Tuscan, Linda Sanders, Kurt R. Stenmark, Paul W. Buehler, Edford Sinkala, David C. Irwin, Sula Mazimba, Brian B. GrahamUniversity of Colorado Anschutz Medical Campus. National Heart Hospital Lusaka and

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An Approach to Children with Pulmonary Edema at High Altitude

Deborah R. Liptzin, Steven H. Abman, Ann Giesenhagen, D. Dunbar IvyUniversity of Colorado School of Medicine and Children’s Hospital ColoradoUnited States High Altitude Medicine and BiologyHigh Altit Med Biol 2018;DOI: 10.1089/ham.2017.0096 AbstractIntroduction: Diagnosis of high-altitude illness can be more challenging in children, especially those who are preverbal. Families often travel to high elevations for family vacations, either

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A prospective, multicenter, open-label, single-arm Phase 2 study to investigate the pharmacokinetics, safety, tolerability, and exploratory efficacy of selexipag in children with pulmonary arterial hypertension

Maurice Beghetti, Lene Nygaard Axelsen, Julian I. Borissoff, Mahdi Farhan, Simon Grill, Sining Leng, Alberto Russu, Catherine Lesage, Tatiana Remeňová, Shu-Fang Hsu Schmitz, Shahin MoledinaUniversity Hospitals of Geneva. Johnson & Johnson. Great Ormond Street Hospital. Switzerland and United Kingdom ChestChest 2025; DOI: 10.1016/j.chest.2025.12.013 AbstractBackground: Selexipag is an oral selective prostacyclin receptor agonist approved for treating pulmonary arterial

A prospective, multicenter, open-label, single-arm Phase 2 study to investigate the pharmacokinetics, safety, tolerability, and exploratory efficacy of selexipag in children with pulmonary arterial hypertension Read More »

Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles

Usha S. Krishnan, Mary P. MullenVagelos College of Physicians and Surgeons of Columbia University Irving Medical Center and Morgan Stanley Children’s Hospital of New York Presbyterian. Boston Children’s Hospital and Harvard Medical School. United States Comprehensive Physiology Interorgan Communication in Health and DiseaseCompre Physiol 2025; DOI: 10.1002/cph4.70085 AbstractUnderstanding communication between various organ systems is vital to

Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles Read More »

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study

Feng Xie, Philip Chung, Jonathan D. Reiss, Erico Tjoa, Davide De Francesco, Thanaphong Phongpreecha, William Haberkorn, Dipro Chakraborty, Alan Lee Chang, Tomin James, Yeasul Kim, Samson Mataraso, Camilo Espinosa, Liu Yang, Chi-Hung Shu, Lei Xue, Eloïse Berson, Neshat Mohammadi, Sayane Shome, S Momsen Reincke, Marc Ghanem, Ivana Maric, Brice Gaudilliere, Martin S Angst, Karl Sylvester,

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study Read More »

Reduction in Prostacyclin Infusion Errors Following a Comprehensive Multidisciplinary Process Transformation for Hospitalized Pediatric Patients with Pulmonary Hypertension: A Quality Improvement Project

Christa Kirk, Anne Davis, Delphine YungDuquesne University School of Pharmacy. Seattle Children’s Hospital. University of Washington School of Medicine.United States Journal of Pediatric Pharmacology and TherapeuticsJ Pediatr Pharmacol Ther 2025; 30: 800-806DOI: 10.5863/JPPT-25-00033 AbstractObjective: Owing to a rise in potentially serious errors with parenteral prostacyclin infusions associated with using an unfamiliar MedFusion 3500 syringe pump (MedFusion), we

Reduction in Prostacyclin Infusion Errors Following a Comprehensive Multidisciplinary Process Transformation for Hospitalized Pediatric Patients with Pulmonary Hypertension: A Quality Improvement Project Read More »

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Yanmin Pei, Meidong Si, Xuemei Ma, Siyun Liu, Fang Zhao, Ru ZhouNingxia Medical University and General Hospital of Ningxia Medical University.China Drug Design, Development and TherapyDrug Des Dev Ther 2025; 19: 11119-11144DOI: 10.2147/DDDT.S547530 AbstractPurpose: 18β-Glycyrrhetinic acid liposomes (18β-GA-Lips) were developed to enhance lung-specific drug delivery and optimize the therapeutic management of pulmonary arterial hypertension (PAH).Methods: 18β-GA-Lips of varying

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension Read More »

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