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Targeted Flow Cardiac MRI in Neonates with Intracardiac Shunts: A Novel Multi-Modality Imaging Approach to Hemodynamic Assessment

Charles T. Simpkin, Anne C. Taylor, Jessica MacLean, Michael Cookson, Richard Friesen, Emily Downs, D. Dunbar Ivy, Cesar Gonzalez de Alba, Benjamin S. FrankUniversity of Colorado Medical Campus and Children’s Hospital Colorado.United States Journal of PediatricsJ Pediatr 2026; DOI: 10.1016/j.jpeds.2026.115261 AbstractDistinguishing the relative contributions of pulmonary vascular resistance and intracardiac shunts to elevated right-heart pressures in […]

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Metabolic reprogramming in pulmonary arterial hypertension

Jun-Zhuo Shi, Jing-Song Ye, Xiao-Rui An, Guo Cheng, Xin Fan, Fang-Fang Meng, Ou Yang, Yang-Han-Yue Zhou, Meng-Jie Zhang, Tian-Yi Yuan, Yi Yan, Yang-Yang HeHuaihe Hospital and Henan University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Chinese Academy of Medical Sciences and Peking Union Medical College. Pharmacology and TherapeuticsPharmacol Ther 2026;

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Intra- and Peri-Operative Cardiac Arrest in Pediatric Patients: Epidemiology, Risk Factors, Mechanisms, and Management Strategies

Eleni Asimacopou;os, Gloria M. Al Karaki, Kirsten C. OdegardBoston Children’s Hospital.United States Paediatric AnaesthesiaPaediatr Anaesth 2026; DOI: 10.1002/pan.70265 AbstractIntraoperative (IOCA) and perioperative cardiac arrest (POCA) in pediatric patients represents a rare but catastrophic event with significant implications for morbidity and mortality. Despite advances in anesthetic techniques, monitoring technology, and resuscitation protocols, the incidence of IOCA and

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Respiratory-Related Hospital Admissions in Children and Young Adults With Down Syndrome

Emily DeBoer, Kristine Wolter-Warmerdam, Rebecca Bernstein, Arwen Jackson, Jennifer Maybee, Karen Kelminson, Francis HickeyUniversity of Colorado and Children’s Hospital Colorado.United States Hospital Pediatrics Hosp Pediatr 2026; DOI: 10.1542/hpeds.2025-008731 AbstractBackground: Children with Down syndrome (DS) have an increased risk for hospitalization and intensive care owing to respiratory illnesses; however, current research does not specify which co-occurring diagnoses increase

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Expanding the phenotypic and genotypic spectrum of KCNT1-related epilepsies

Mathilde Gras, Gaelle Quentin-Romand, Nicole Chemaly, Giulia Barcia, KCNT1 consortium and Rima NabboutNecker Enfants Malades Hospital and Université Paris Cité. France Brain CommunicationsBrain Commun 2026; 8: DOI: 10.1093/braincomms/fcag256 AbstractThe KCNT1 gene encodes for a sodium-activated potassium channel involved in neuronal excitability. Since its initial description in 2012 in patients with Epilepsy of Infancy with Migrating Focal Seizures (EIMFS)

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Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare

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Thoracoscopic Versus Open Repair of Congenital Diaphragmatic Hernia: A Retrospective Case Series From a Tertiary Care Center

Shishir Kumar, Ratan Kumar, Mrunalkant Panchal, Preeti Srivastava, Sanjay K. TantiTata Main Hospital, Manipal Tata Medical College and Manipal Academy of Higher Education.India CureusCureus 2026; 18: DOI: 10.7759/cureus.111125 AbstractBackground: Congenital diaphragmatic hernia (CDH) remains a challenging neonatal surgical condition associated with significant morbidity and mortality. Thoracoscopic repair has emerged as a minimally invasive alternative to conventional open

Thoracoscopic Versus Open Repair of Congenital Diaphragmatic Hernia: A Retrospective Case Series From a Tertiary Care Center Read More »

Placental abnormalities of malperfusion, inflammation, and meconium are associated with neonatal pulmonary vascular disease

Stephanie M. Tsoi, Cynthia Gasper, Emin Maltepe, Megan A. Chidboy, Nida Ozarslan, Christine A. Blauvelt, Sirirak Buarpung, Shannon Cheung, Martina Steurer, Roberta L. Keller, Jeffrey R. Fineman, Stephanie L. GawUniversity of California San Francisco. United States PlacentaPlacenta 2026; 182: 341-347DOI: 10.1016/j.placenta.2026.06.024 AbstractObjectives: The primary objective was to elucidate whether placental histopathology representative of intrauterine insults during pulmonary

Placental abnormalities of malperfusion, inflammation, and meconium are associated with neonatal pulmonary vascular disease Read More »

Growth-adjusted reference values for the main pulmonary artery-to-ascending aorta ratio derived from clinically indicated chest CT in children

Ying Lyu, Mingshu Yang, Huaqin Bu, Chao Gong, Jinhua Ma, Tingting Luo, Li Zhong, Yongle Zhao, Xiao Yang, Ting Wang, Yan Chen, Daiyin TianChildren’s Hospital of Chongqing Medical University and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Children’s Hospital of Fudan University and National Children’s Medical Center. China European RadiologyEur Radiol

Growth-adjusted reference values for the main pulmonary artery-to-ascending aorta ratio derived from clinically indicated chest CT in children Read More »

Outcome of biventricular repair of congenital cardiac malformations with a borderline left ventricle

Emilie Houdebert, Victoria Benito Arnaiz, Antonio Gonzalez-Calle, Mustafa Rady, Giulia Scopetani, Lorenzo Boni, Maria-Helena Perez, Nicole Sekarski, Stefano Bernardo, Andrew Parry, Amir-Reza HosseinpourLausanne University Hospital and University of Lausanne. University Hospital of Madrid. Virgen del Rocio Hospital and University Hospitals of Seville. Bristol Children’s Hospital. Switzerland, Spain and United Kingdom Journal of Cardiothoracic SurgeryJ Cardiothorac Surg

Outcome of biventricular repair of congenital cardiac malformations with a borderline left ventricle Read More »

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