Medical Therapy. Efficacy or Lack of Efficacy

Reversible Pulmonary Hypertension in CblC Deficiency (MMACHC c.80 A>G): long-term outcomes of metabolic and PH-targeted therapy

Ruxuan He, Jinrong Liu, Xiaolei Tang, Hui Liu, Yuelin Shen, Xioayan Zhang, Huimin Li, Shunying Zhao, Haiming YangBeijing Children’s Hospital and Capital Medical University. Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children’s Hospital and Seventh People’s Hospital of Xinjiang Uygur Autonomous Region.China Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04720-8 AbstractBackground: Cobalamin C (cblC) deficiency, […]

Reversible Pulmonary Hypertension in CblC Deficiency (MMACHC c.80 A>G): long-term outcomes of metabolic and PH-targeted therapy Read More »

A prospective, multicenter, open-label, single-arm Phase 2 study to investigate the pharmacokinetics, safety, tolerability, and exploratory efficacy of selexipag in children with pulmonary arterial hypertension

Maurice Beghetti, Lene Nygaard Axelsen, Julian I. Borissoff, Mahdi Farhan, Simon Grill, Sining Leng, Alberto Russu, Catherine Lesage, Tatiana Remeňová, Shu-Fang Hsu Schmitz, Shahin MoledinaUniversity Hospitals of Geneva. Johnson & Johnson. Great Ormond Street Hospital. Switzerland and United Kingdom ChestChest 2025; DOI: 10.1016/j.chest.2025.12.013 AbstractBackground: Selexipag is an oral selective prostacyclin receptor agonist approved for treating pulmonary arterial

A prospective, multicenter, open-label, single-arm Phase 2 study to investigate the pharmacokinetics, safety, tolerability, and exploratory efficacy of selexipag in children with pulmonary arterial hypertension Read More »

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Yanmin Pei, Meidong Si, Xuemei Ma, Siyun Liu, Fang Zhao, Ru ZhouNingxia Medical University and General Hospital of Ningxia Medical University.China Drug Design, Development and TherapyDrug Des Dev Ther 2025; 19: 11119-11144DOI: 10.2147/DDDT.S547530 AbstractPurpose: 18β-Glycyrrhetinic acid liposomes (18β-GA-Lips) were developed to enhance lung-specific drug delivery and optimize the therapeutic management of pulmonary arterial hypertension (PAH).Methods: 18β-GA-Lips of varying

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Reversible pulmonary hypertension in a patient diagnosed with scurvy

Gregory Berra, Léon Genecand, Anais Juillet, Jean-François Deux, Paco Prada, Hajo Müller, Marco Roffi, Maurice BeghettiGeneva University Hospitals. Switzerland British Medical Journal Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2025-266143 AbstractThis case report describes a woman in her late 50s with reversible pulmonary hypertension (PH) due to scurvy, a rare vitamin C (ascorbic acid) deficiency in

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Use of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors in Pulmonary Hypertension

Benoit Aguado, Grégoire Ruffenach, Thomas Lacoste-Palasset, Agnes Görlach, Marianne Riou, Mathieu Gourmelon, Fabrice Bauer, Marc Humbert, Valerie Schini-Kerth, Jean-Luc Vachiéry, David Montani, Fabrice AntignyUniversité Paris-Saclay and French National Institute for Health and Medical Research. Hôpital Bicêtre and Hôpital Marie Lannelongue. Technical University Munich and German Centre for Cardiovascular Research. Nouvel Hôpital Civil and University Hospital

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Exchange transfusion for hyperleucocytosis in a critical case of pertussis

Nihil Akcay, Demet Tosun, Ilyas BingölUniversity of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital.Turkey Paediatrics and International Child HealthPaediatr Int Child Health 2025; DOI: 10.1080/20469047.2025.2595836 AbstractAn 8-week-old infant girl with pertussis-induced respiratory distress, complicated by severe leucocytosis, pulmonary hypertension and respiratory failure is reported. She was treated with mechanical ventilation, exchange transfusion and other

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Clinical characteristics of children treated with high-frequency oscillation ventilation

Lihua Wen, Xiaohuan Guo, Yiyu Yang, Run Dang, Chunmin Zhang, Feiyan ChenGuangzhou Women and Children’s Medical Center and Guangzhou Medical University.China MedicineMedicine 2025; 104: DOI: 10.1097/MD.0000000000046288 AbstractHigh-frequency oscillation ventilation (HFOV) is a commonly used therapeutic modality in the pediatric intensive care unit, and this study aims to investigate the clinical characteristics of children treated with HFOV.

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Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study

Iwona Sadowska-Krawczenko, Roman Hożejowski, Jan Mazela, Katarzyna Wróblewska-Seniuk, Tomasz Szczapa, Mateusz Jagła, Piotr Kruczek, Katarzyna Bierła, Renata BokiniecNicolaus Copernicus University in Torun. University Hospital No. 2 in Bydgoszcz. Chiesi Poland. Poznan University of Medical Sciences. Jagiellonian University Medical College. Czerwiakowski Hospital at Siemiradzki. District Hospital, Ostrow. Medical University of Warsaw.Poland Pediatric ResearchPediatr Res 2025;DOI: 10.1038/s41390-025-04634-5 AbstractBackground: Surfactant

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Volume Loading May Compromise Left Ventricular Filling in Patients with a Borderline Hypoplastic Left Ventricle

Machi Yamashita, Hirofumi Saiki, Kanchi Saito, Akira Sato, Seiko Kuwata, Satoshi Nakano, Hideaki Senzaki, Junichi KoizumiIwate Medical University. Nihon Institute of Medical Science.Japan International Heart JournalInt Heart J 2025; 66: 1019-1024DOI: 10.1536/ihj.25-216 AbstractGiven the high prevalence of end-organ damage in the long term after the Fontan procedure, patients presenting with borderline hypoplastic left ventricle (LV) are

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Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension

Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils-Bonnet, Martin Wabitsch, Margaret R. MacLeanUniversity of Strathclyde. Queen Mary University of London. Medical University of Vienna. University of Edinburgh. Laval University. Ulm University Medical Center.United Kingdom, Austria, Canada and Germany

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