Medical Therapy. Efficacy or Lack of Efficacy

Inhaled Nitric Oxide via High-Flow Nasal Cannula in Postrepair Congenital Heart Disease Patients With Pulmonary Arterial Hypertension Following Extubation: A Cohort Study With Propensity Score Matching

Xiaofeng Wang, Qinnan Chen, Shilin Wang, Zhiyuan Zhu, Hong Gu, Xu WangNational Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Anzhen Hospital and Capital Medical University.China World Journal of Pediatric and Congenital Heart SurgeryWorld J Pediatr Congenit Heart Surg 2026; DOI: 10.1177/21501351261450515 AbstractObjective: For pediatric patients with

Inhaled Nitric Oxide via High-Flow Nasal Cannula in Postrepair Congenital Heart Disease Patients With Pulmonary Arterial Hypertension Following Extubation: A Cohort Study With Propensity Score Matching Read More »

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats

Guoliang Wang, Jie Liu, Peiyi Bai, Hong Jiao, Xiaohui Kong, Zhangke Guo, Gaopeng Li, Aijun LiuBeijing Children’s Hospital, Beijing Pediatric Research Institute, Capital Medical University and National Center for Children’s Health. Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences and Tongji Shanxi Hospital. General Hospital of Taiyuan Iron and

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats Read More »

Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition

Tomaž Podnar, Ralf Geiger, Ira Winkler, Elke Griesmaier, Susanne Sprung, Ursula Kiechl-KohlendorferMedical University of Innsbruck. Tirol Kliniken.Austria Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1753196 AbstractBackground: The foramen ovale (FO) plays a central role in fetal circulation. Prenatal FO closure or restriction is well-characterized in fetuses and in neonates with congenital heart defects, but is rarely described

Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition Read More »

Alveolar Capillary Dysplasia With Misaligned Pulmonary Veins (ACDMPV): Description of Two Cases and Literature Review

Eleanora Guasti, Giacomo Tardini, Silvia Buratti, Chiara Campone, Erika Alboreto, Martino Cheli, Francesca Faravelli, Daniela Pirlo, Andrea MoscatelliUniversity of Genoa. IRCCS Istituto Giannina Gaslini. Italy Pediatric PulmonologyPediatr Pulmonol 2026; 61: DOI: 10.1002/ppul.71704 AbstractIntroduction: Alveolar capillary dysplasia with misaligned pulmonary veins (ACDMPV) is one of the major causes of neonatal interstitial lung disease, causing persistent pulmonary hypertension (PH)

Alveolar Capillary Dysplasia With Misaligned Pulmonary Veins (ACDMPV): Description of Two Cases and Literature Review Read More »

Efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis

Guanghong Li, Xiaoqun Du, Weibin Luo, Junhua Wei, Huiyi HuangHuadu District People’s Hospital of Guangzhou.China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1836276 AbstractObjective: To evaluate the efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN).Methods: PubMed, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception to March

Efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis Read More »

Autologous stem cell transplantation (ASCT) for Refractory juvenile-onset systemic sclerosis (JSSc)

Kathryn S. Torok, Paulina Horvei, Jonathan Li, Franziska Rosser, Jessie L. Alexander, Kirsten Rose-felker, Vibha Sood, Adam Olson, Nicole Hogue, Vickie Vandergrift, Heather Stanczak, Maura Miglioretti, Lauren Farver, Wendy Koster, Devin Mcguire, Haley Havrilla, Shawna McIntyre, Robyn T. Domsic, Robert A. Lafyatis, Paul SzabolcsUniversity of Pittsburgh Medical Center (UPMC) and Children’s Hospital of Pittsburgh. Stanford

Autologous stem cell transplantation (ASCT) for Refractory juvenile-onset systemic sclerosis (JSSc) Read More »

Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report

C. Noah Nilsson, Othman A. Aljohani, Michael A. Smith, Rachelle Durand, Inger Norlyk Sheyanth, Hythem Nawaytou, Elliot Stieglitz, Russel Valle, Sanjeev A. DatarUniversity of California San Francisco. Copenhagen University Hospital. United States and Denmark Clinical Case ReportsClin Case Rep 2026; 14:DOI: 10.1002/ccr3.72831 AbstractThis case describes a female infant with RAF1-related Noonan syndrome who developed severe hypertrophic obstructive

Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report Read More »

Case Report: Post-Total anomalous pulmonary venous connection pulmonary hypertension – novel treatment using sirolimus and atrial flow regulator implantation

Stasa Krasic, Antony Hermuzi, Ivan Dizdarevic, Vesna Topic, Nevena Djorovic, Mihail Basa, Vladislav VukomanovicMother and Child Health Institute of Serbia and University of Belgrade. Freeman Hospital and Newcastle upon Tyne Hospitals NHS Foundation Trust. Serbia and United Kingdom Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13: DOI: 10.3389/fcvm.2026.1783773 AbstractObjective: In patients who have undergone surgical repair of

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A Life Without Lemons: A Case of Severe Pulmonary Arterial Hypertension Secondary to Vitamin C Deficiency in a Child With Autism Spectrum Disorder

Beau Redwood, Simon Erickson, Lily Loughman, Zoe VettenPerth Children’s Hospital. Genetic Services of Western Australia.Australia Journal of Pediatrics and Child HealthJ Pediatr Child Health 2026; DOI: 10.1111/jpc.70448 AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic, Nutritional and Other DisordersMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh

A Life Without Lemons: A Case of Severe Pulmonary Arterial Hypertension Secondary to Vitamin C Deficiency in a Child With Autism Spectrum Disorder Read More »

A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo Heterozygous CAV1 Mutation in a Pediatric Patient

Yan Sun, Qingyou Zhang, Yaqian Huang, Xueqin LiuPeking University First Hospital.China ChildrenChildren 2026; 13: DOI: 10.3390/children13050694 AbstractBackground: Pulmonary arterial hypertension is a rare but life-threatening condition in children, with hereditary forms often being linked to mutations in genes such as bone morphogenetic protein receptor type 2 (BMPR2), caveolin 1 (CAV1), and potassium channel subfamily K member

A Rare Case of Multi-System Involvement and Hereditary Pulmonary Hypertension Caused by De Novo Heterozygous CAV1 Mutation in a Pediatric Patient Read More »

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