Medical Therapy. Efficacy or Lack of Efficacy

Scimitar syndrome presenting as respiratory distress in a term neonate: A rare case report

Iqra Javed, Musawer Khan, Haya, Sana Imtiaz, Muhammad Shoaib, MBBS, Yusra Iqbal, Khwaja Waleed Maqbool, Kamil Ahmad KamilCombined Military Hospital Quetta. SMBZAN Institute of Cardiology. Quetta Institute of Medical Sciences. Mirwais Regional Hospital.Pakistan and Afghanistan Radiology Case ReportsRadiol Case Rep 2026; 21: 2982-2987DOI: 10.1016/j.radcr.2026.03.021 AbstractScimitar syndrome is a rare congenital cardiopulmonary anomaly characterized by partial anomalous […]

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Pediatric autoimmune pancarditis complicated by congenital heart disease: a case of severe multivalvular dysfunction and fibrinous pericarditis

Pramod Kumar, Kumar Ratnjeet, Baiju Sasi Dharan, Rajalakshmi Poyuran, Arun GopalakrishnanSree Chitra Thirunal Institute for Medical Sciences and Technology. India Indian Journal of Thoracic and Cardiovascular SurgeryIndian J Thorac Cardiovasc Surg 2026; 42: 806-811DOI: 10.1007/s12055-026-02179-8 AbstractAutoimmune carditis in children is uncommon and often overlooked, particularly in regions where rheumatic fever is endemic. We report the case

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Early postoperative treprostinil in for severe pulmonary arterial hypertension in a high-risk pediatric patient with complete atrioventricular septal defect: a case report

Sha Zhao, Zhong-yuan Lu, Pantao Zhou, Li Xiong, Xiao-Bin LiAffiliated Traditional Chinese Medicine Hospital and Southwest Medical University. Beijing No.6 Hospital. Fuwai Hospital. Gulin Municipal Hospital of Traditional Chinese Medicine. China BioMedical Central Cardiovascular DisordersBMC Cardiovasc Disord 2026; DOI: 10.1186/s12872-026-05954-y AbstractBackground: Perioperative management of pediatric patients with congenital heart disease (CHD) and severe pulmonary arterial hypertension (PAH)

Early postoperative treprostinil in for severe pulmonary arterial hypertension in a high-risk pediatric patient with complete atrioventricular septal defect: a case report Read More »

Sotatercept administration in a young infant with severe pulmonary arterial hypertension: A case report

Arjith V. Rathakrishnan, Jenna Torgeson, Arij Beshish, Monica C. Bogenschutz, Vivek Balasubramaniam, Luke J. LamersUniversity of Wisconsin–Madison and UW Health Kids-Madison.United States Frontiers in PediatricsFront Pediatr 2026; DOI: 10.3389/fped.2026.1806079 AbstractIdiopathic pulmonary arterial hypertension (PAH) in infants is a rare, life-threatening condition characterized by elevated pulmonary artery pressure resulting from endothelial dysfunction, vasoconstriction, and vascular remodeling. The

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Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension

Yong‐Jian Zhu, Jie‐Jian Kou, Ya‐Cong Bo, Meng‐Jie Zhang, Xin Fan, Lu‐Ling Zhao, Yi Yan, Hong Da Zhang, Wen‐Hui Wu, Ping Yuan, Yan Liu, Jun‐Zhuo Shi, Xiao‐Bin Pang, Yang‐Yang HeFirst Affiliated Hospital of Zhengzhou University. Huaihe Hospital and Henan University. Zhengzhou University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital and Peking Union Medical College. Shanghai Pulmonary Hospital and School of Medicine Tongji University. China Journal of the American Heart AssociationJ Am Heart Assoc

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

Descriptive study of the effects of treprostinil and/or epoprostenol in newborn infants with inhaled NO refractory persistent pulmonary hypertension of the newborn (PPHN)

Charlotte Mazepa, Sébastien Mur, Géraldine Gascoind, Laurent Storme, Nicolas Joram, Caroline Viard, Yves Dulac, Marine Butini, Sophie BreinigChildren’s Hospital, CHU de Toulouse and Université de Toulouse. Lille University Hospital. Jeanne-de-Flandre Hospital and CHU de Lille. Nantes University Hospital. Hôpital Femme-Mère-Enfant, Hospices civils de Lyon and Université Claude-Bernard-Lyon. France TherapeuticsTherapie 2026; DOI: 10.1016/j.therap.2026.03.001 AbstractBackground: Epoprostenol and treprostinil, prostacyclin

Descriptive study of the effects of treprostinil and/or epoprostenol in newborn infants with inhaled NO refractory persistent pulmonary hypertension of the newborn (PPHN) Read More »

Pulmonary arterial hypertension in infancy: A case series

N. V. Shashikala, K. M. Arun, R. C. Ashwini, Muganagowda PatilBapuji Child Health Institute and Research Centre. India Tropical DoctorTrop Doct 2026;DOI: 10.1177/00494755261451113 AbstractThiamine deficiency is a reversible cause of severe pulmonary arterial hypertension (PAH) in early infancy, particularly among exclusively breastfed infants of mothers consuming polished rice-based diets. This retrospective case series (July 2023-July 2025)

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Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary Dysplasia (SILDI-SAFE): A Randomized Controlled Trial

Wesley M. Jackson, Henry P. Foote, Nicole Stephenson, Steven M. Kemp, Ryan T. Moore, Christopher R. Nitkin, Dan Stewart, Gloria S. Pryhuber, John T. Berger, Ankita Shukla, Amand England, Stephanie M. Ford, Lance A. Parton, Jennifer F. Check, Mina H. Hanna, Megan Lagoski, Ramesh Krishnan, Kristen T. Leeman, Shilpa Vyas-Read, Mark L. Hudak, Anup C.

Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary Dysplasia (SILDI-SAFE): A Randomized Controlled Trial Read More »

Experience with selexipag in triple therapy for pulmonary arterial hypertension in Chinese children

Meng Li, Yingchun Wang, Xiaoyu Hu, Haizhao Zhao, Weida Lu, Yuan Ji, Xiaopei CuiQilu Hospital and Cheeloo College of Medicine of Shandong University. China BioMedical Central PediatricsBMC Pediatr 2026; DOI: 10.1186/s12887-026-06954-9 AbstractBackground: Selexipag is an orally effective prostacyclin receptor agonist that has been approved for treating pulmonary arterial hypertension (PAH) in adults but is still used off-label

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Successful Completion of High-Risk Neuroblastoma Therapy After Stabilization of Pulmonary Hypertension With Tadalafil

Takuma Sugahara, Hirohito Kubota, Tatsuya Kamitori, Koichi Matsuda, Shiro Baba, Katsutsuga Umeda, Junko TakitaKyoto University.Japan Pediatric InternationalPediatr Int 2026; DOI: 10.1111/ped.70427 AbstractAbstract Not Available CategoryMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access Free PDF File or Full

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