Medical Therapy. Efficacy or Lack of Efficacy

High-Altitude Pulmonary Edema in Children in Mexico City: A Case Series

Alejandro Ferreiro Marin. María Paula Ferreiro Soria, Karla Sánchz Olivera, Aranza Suárez Ortega, Luis Martin Garrido GarcíaCentro Médico ABC. Universidad Anáhuac México.Mexico High Altitude Medicine and BiologyHigh Alt Med Biol 2026; DOI: 10.1177/15578682261500306 AbstractHigh-altitude pulmonary edema (HAPE) is a potentially life-threatening form of noncardiogenic pulmonary edema caused by hypobaric hypoxia. Although well characterized in adults,

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Use of sotatercept in an adolescent patient with idiopathic pulmonary arterial hypertension

Kohei Kurosaki, Yohei Akazawa, Tomoyasu Yuki, Kohta Takei, Kiyohiro TakigikuNagano Children’s Hospital. Japan Journal of Cardiology CasesJ Cardiol Cases 2026; 34: 173-176DOI: 10.1016/j.jccase.2026.06.010 AbstractAn adolescent boy with idiopathic pulmonary arterial hypertension (iPAH) presented with persistent pulmonary hypertension with right ventricular dysfunction despite upfront oral triple combination therapy. Additional sotatercept treatment led to a striking improvement

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Antithrombotic Therapy Use in Children With Pulmonary Hypertension

Meredith J. O’Neil, Lynn A. Sleeper, Nidhy P. Varghese, Paul J. Critser, Eric D. Austin, Catherine M. Avitabile, Angela Bates, Erika B. Rosenzweig, Carly E. Byrd, Patrick D. Evers, Stephanie S. Handler, Rachel K. Hopper, Emma O. Jackson, Roberta L. Keller, Usha S. Krishnan, Minmin Lu, Jessica Maclean, Raysa Morales‐Demori, Mary P. Mullen, Meredith Riker,

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Sotatercept in Pediatric Pulmonary Hypertension: Experience from the Pediatric Pulmonary Hypertension Network

Paul J. Critser, Usha S. Krishnan, Catherine M. Avitabile, Andrea L. Jones, Benjamin S. Frank, Dunbar D. Ivy, Emily P. Williams, Rachel T. Sullivan, Eric D. Austin, Dephine Yung, Stephanie S. Handler, Edward Kirkpatrick, Mary P. Mullen, Claire Parker, Megan Griffiths, Patrick D. Evers, Meredith J. O’Neil, Neelam D. Bhatt, Rachel Capote, Erika B. Rosenzweig,

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Investigation of the Effects of Switching from Bosentan to Macitentan in Pediatric Pulmonary Hypertension Patients

Mustafa Mertkan Bilen, Timur Mese, Murat Muhtar Yilmazer, Gamze Vuran, Cem Dogan, Yusuf Ilker Dur, Ozan HiraUniversity of Health Sciences, Dr. Behcet Uz Pediatric Diseases And Surgery Training and Research Hospital.Turkey Medical Bulletin of Sisli Etfal Hospital Sisli Etfal Hastan Tip Bul 2026; 60: 405-411DOI: 10.14744/SEMB.2026.78803 AbstractObjectives: Pulmonary arterial hypertension (PAH) is a progressive disease

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High-Frequency Oscillatory Ventilation Combined With Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Single-Center Randomized Clinical Trial

Yanbo Wang, Qian Wu, Xin Zhang, Zhongyi Sun, Mingming Zhang, Xiao Liu, Bin ZhouXuzhou Central Hospital.China Canadian Respiratory JournalCan Respir J 2026; DOI: 10.1155/carj/8717590 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) may respond incompletely to inhaled nitric oxide (iNO) when poorly recruited lung limits delivery to ventilated alveoli. We evaluated whether high-frequency oscillatory ventilation

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Imatinib Mesylate and Sirolimus Inhibit Vascular Fibroproliferative Remodeling in Pulmonary Vein Stenosis

Julia Gaal, Sophie C. Doettl, Kerstin Saraci, Cindy Zajac, Alexa von Mueffling, Peter E. Hammer, Magnus von Piechowski, Verena Gebert, Andrei-Antonio M. Caracioni, Daniel Diaz-Gil, Viktoria Weixler, Pedro J. Del Nido, Kathy Jenkins, Ingeborg FriehsBoston Children’s Hospital and Harvard Medical School. German Heart Center of Charité-Universitätsmedizin Berlin.United States and Germany ChildrenChildren 2026; 13: DOI: 10.3390/children13091280

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Long-Term Subcutaneous Treprostinil in Pediatric Pulmonary Arterial Hypertension at a Latin American Referral Center: A Retrospective Cohort Study

Angelo Valencia Salazar, Ernesto León Vallejo MondragónClínica Imbanaco.Columbia Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70395 AbstractPediatric pulmonary arterial hypertension is a progressive vasculopathy with substantial early mortality. Subcutaneous treprostinil is an established prostacyclin-pathway therapy for higher-risk disease, but long-term pediatric data from Latin American referral centers remain limited. This retrospective cohort included all nine consecutive

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Sotatercept in Pediatric Pulmonary Hypertension: Promising Hemodynamic Findings, but Are We Extrapolating Too Far?

Alper AkinDicle University Medical Faculty. Turkey Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04492-w AbstractA recent study reporting the off-label use of sotatercept in pediatric pulmonary arterial hypertension presents important hemodynamic findings. However, the small and heterogeneous patient cohort-which also included patients with Group 3 pulmonary hypertension and uncorrected Eisenmenger physiology-limits the generalizability of these findings. These

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An infant with persistent pulmonary hypertension of the newborn and congenital hypothyroidism

Georgia Eva Fouli, Raghavendra Subba-Rao, Ravindra Bhat, Anne GreenoughKing’s College Hospital. United Kingdom Case Reports in Perinatal MedicineCase Rep Perinat Med 2026; DOI: 10.1515/crpm-2026-0003 AbstractObjectives: We report an infant who presented with persistent pulmonary hypertension of the newborn (PPHN) to highlight this was likely due to congenital hypothyroidism.Case presentation: A male infant born at term presented with respiratory

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