Medical Therapy. Efficacy or Lack of Efficacy

Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia

Ryosuke Miura, Atsuto Onoda, Azusa Okamoto, Toshihiko Suzuki, Takahiro Kanzawa, Sakiko Suzuki, Kazuto Ueda, Shinobu Shimizu, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki SatoNagoya University Hospital and Nagoya University Graduate School of Medicine. Sanyo-Onoda City University. Japan Stem Cell Research and TherapyStem Cell Res Ther 2026; 17: DOI: 10.1186/s13287-026-05086-2 AbstractBackground: Neonatal bronchopulmonary dysplasia (BPD) is a lung injury caused […]

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The Use of Inhaled Nitric Oxide After Pediatric Cardiac Surgery

J. Wesley Diddle, Jason Patregnani, Claudia A. Algaze, Mousumi, Banerjee, John Berger, Garrett Reichle, James St. Louis, Jun Sasaki, Kurt R. Schumacher, Jamie Sinton, William Stigall, Joshua Wolovits, Wenying Zhang, Sarah TabbuttChildren’s Hospital of Philadelphia and University of Pennsylvania. Barbara Bush Children’s Hospital. Lucile Packard Children’s Hospital and Stanford University. University of Michigan. Children’s National

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Long-term management of a child with aortopulmonary septal defect and Eisenmenger syndrome: a 6-year follow-up case study

Daniela Milanova-Ilieva, Kostadin Ketev, Ivanka Karavelikova, Lyubov Chochkova-Bukova, Elisaveta Levunlieva, Anna Kaneva-NenchevaSt George University Hospital. Medical University of Plovdiv, Plovdiv. National Heart Hospital. National Cardiology Hospital.Bulgaria Folia MedicaFolia Med 2026; 68: DOI: 10.3897/folmed.68.e149000 AbstractWe report the case of a boy diagnosed at age 9 with a large aortopulmonary septal defect and Eisenmenger syndrome, highlighting the challenges

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Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn

Sania El-HindiChildren’s Hospital of Damascus University.Syria World Journal of Clinical PediatricsWorld J Clin Pediatr 2026; 15: DOI: 10.5409/wjcp.118862 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) remains a challenging condition with high morbidity and mortality despite advancements in management, which implies the need to investigate new therapies. While sildenafil is the drug of choice in resource-limited centers

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Efficacy, Safety, and Pharmacokinetics of Macitentan in Japanese Pediatric Patients With Pulmonary Arterial Hypertension: Prospective, Multicenter, Open-Label Study

Ryo Inuzuka, Taku Ishii, Toru Iwasa, Kenichi Kurosaki, Ayako Kuraoka, Jun Narita, Shinichi Takatsuki, Masayoshi Nakano, Rieko Inagaki, Maki Mihoya, Kim Hyunsoo, Minaka Shibuya, Tohru Kobayashi, Hidekazu Ishida, Taichi Kato, Masaru Miura, Hiroyuki Yamagishi, Shozaburo DoiUniversity of Tokyo. Institute of Science Tokyo Hospital. National Cerebral and Cardiovascular Center. Fukuoka Children’s Hospital. University of Osaka Graduate

Efficacy, Safety, and Pharmacokinetics of Macitentan in Japanese Pediatric Patients With Pulmonary Arterial Hypertension: Prospective, Multicenter, Open-Label Study Read More »

Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report

Miki Kanai, Hirofumi Tsuru, Takanori Onuki, Shunsuke Nukaga, Shigehito Baba, Masanori Tsukada, Tadaaki Abe, Fujito Numano, Kei Murayama, Akihiko SaitohSaiseikai Niigata Kenoh Kikan Hospital. Niigata University School of Medicine. Juntendo University. Japan Internal MedicineIntern Med 2026; DOI: 10.2169/internalmedicine.7614-26 AbstractPulmonary hypertension (PH) is uncommon in myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) and its hemodynamics are poorly

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Pulmonary hypertension and acute hypoxic respiratory failure in preterm neonates

Marwa M. Elgendy, Sfurti NathUniversity of Maryland School of Medicine. Warren Alpert Medical School of Brown University.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02858-9 AbstractPulmonary hypertension (PH) in preterm infants is a complex and heterogeneous condition that significantly contributes to hypoxic respiratory failure (HRF), bronchopulmonary dysplasia (BPD), and mortality. Unlike term infants, PH in preterm

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Improved Outcomes with Early Aggressive Therapy in Pediatric Pulmonary Hypertension

Benjamin S. Frank, Maurice Beghetti, Rolf M. F. Berger, Damien Bonnet, Tilman Humpl, Julie Wacker, Johannes M. Douwes, Julien Grynblat, Paul J. Critser, David Bowers, D. Dunbar Ivy, on behalf of the TOPP-2 InvestigatorsUniversity of Colorado. Geneva University Hospitals and Faculty of Medicine and University of Geneva. Beatrix Children’s Hospital, University Medical Center Groningen and

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Vasopressin for hemodynamic support in neonates: current evidence and clinical applications

Aimann Surak, Mohamed Sewidan, Mimi T. Y. Kuan, Megan Kennedy, Manoj Kumar, Joseph Y. TingUniversity of Alberta. University of British Columbia. Canada Journal of PerinatologyJ Perinatol 2026;DOI: 10.1038/s41372-026-02837-0 AbstractObjective: To systematically map and synthesize the available evidence on the use of vasopressin for hemodynamic support in neonates.Study design: We conducted a scoping review to synthesize available data on

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Inhaled Nitric Oxide and Hypoxic Brain Injury in Newborn Piglets

Shadi Malaeb, John Grothusen, Ferit Tuzer, Maria Delivoria-PapadopoulosDrexel University College of Medicine. United States Nitric OxideNitric Oxide 2026; DOI: 10.1016/j.niox.2026.07.003 AbstractBackground: Inhaled nitric oxide (iNO) is widely used as a pulmonary vasodilator to treat infants with pulmonary hypertension (PHN). Hypoxia (Hx) and acidosis increase pulmonary vascular resistance and contribute to PHN. Perinatal asphyxia and resultant hypoxic-ischemic encephalopathy

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