Medical Therapy. Efficacy or Lack of Efficacy

Treatable Traits in Pediatric Interstitial Lung Diseases: Bridging the Gap to Tailored Therapeutics

Giuseppe Fabio Parisi, Maria Papale, Giulia Pecora, Santiago Presti, Monica Tosto, Salvatore LeonardiSan Marco Hospital and University of Catania.Italy Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14228190 AbstractPediatric interstitial lung diseases (chILD) are a diverse and complex group of rare but impactful disorders characterized by heterogeneous etiologies and variable clinical courses. Traditional diagnosis-based management […]

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Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Eliza Wasilewska, Norbert Dera, Łukasz Minarowski, Łukasz Osinski, Anna Doboszynska, Sławomir Szajda, Alina MinarowskaMedical University of Gdańsk. Center of Postgraduate Medical Education. Warsaw Institute of Women’s Health. Medical University of Bialystok. University Teaching Hospital. Regional Specialist Hospital in Olsztyn. University of Warmia and Mazury in Olsztyn. University of Warmia and Mazury. Children’s University Hospital in

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Efficacy and Tolerability of Selexipag in Pediatric Patients with Pulmonary Arterial Hypertension: An Updated Systematic Review and Meta-analysis

Vasiliki Patsiou, Triantaphyllia Grantza, Thomas Chrysochoidis-Trantas, Maria Kavga, Nikolaos Fragakis, Antonio Ziakas, Alexandra Arvanitaki, George GiannakoulasAHEPA University General Hospital, Hippokrateion General Hospital and Aristotle University of Thessaloniki. Feinstein Institutes for Medical Research. Elmezzi Graduate School of Molecular Medicine and Northwell Health. Royal Brompton Hospital. Greece, United States and United Kingdom Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04094-y

Efficacy and Tolerability of Selexipag in Pediatric Patients with Pulmonary Arterial Hypertension: An Updated Systematic Review and Meta-analysis Read More »

Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN)

Marina S. Oren, Kikelomo Babata, June Hu, Venkatakrishna Kakkilaya, Patti J. Burchfield, Michelle Hagans, L. Steven Brown, Satyan Lakshminrusimha, Vishal KapadiaUniversity of Texas Southwestern Medical Center. Texas Health Presbyterian Hospital of Dallas. Parkland Health & Hospital System. University of California Davis Children’s Hospital.United States Journal of Pediatrics: Clinical PracticeJ Pediatr Clin Pract 2025; 18: DOI: 10.1016/j.jpedcp.2025.200189

Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN) Read More »

Use of milrinone in pediatric intensive care units: a multicenter survey of French-speaking countries

Florian Manoeuvrier, Morgan Recher, Marion Grimaud, Sylvain Renolleau, Olivier Brissaud, Stéphane Leteurtre, Mehdi Oualha, Charles de Marcellus, Groupe Francophone de Réanimation et d’Urgence PédiatriquesCentre-Université de Paris and Necker-Enfants Malades. CHU Amiens-Picardie. Univ.ersity of Lille and CHU Lille. CHU Bordeaux and Pellegrin-Enfants Hospital. France European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06589-5 AbstractPurpose: To assess the

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Marked improvement in severe pulmonary arterial hypertension following airway infection in a patient with a heterozygous BMP9 nonsense mutation: a case report

Makito Sakurai, Yohei Yamaguchi, Kei Takasawa, Susumu Hosokawa, Taku IshiiInstitute of Science Tokyo. Japanese Red Cross Musashino Hospital.Japan European Heart Journal Case ReportsEur Heart J Case Rep 2025; 9: DOI: 10.1093/ehjcr/ytaf386 AbstractBackground: Pulmonary arterial hypertension (PAH) is a severe and life-threatening disease. Genetic factors, inflammation and immune system play important roles in their pathogenesis. However, their precise

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Phenoxybenzamine: Old Wine in a Bright New Bottle-Taming the wild side of Phenoxybenzamine

R. Benedict Raj, Srinath Reddy Narahari, Vasudev Vemala, Jyotiprakash ReddyAster Ramesh Hospitals.India Journal of Pharmacy and BioAllied SciencesJ Pharm Bioall Sci 2025; 17 (Suppl 3): S2135-S2137DOI: 10.4103/jpbs.jpbs_868_25 AbstractBackground: Phenoxybenzamine (PBZ), a long-acting α-blocker, was once widely used in pediatric cardiac surgeries but fell out of favor due to concerns about systemic hypotension. In the context of developing

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Two case reports of idiopathic prenatal closure of the ductus arteriosus complicated at birth by severe pulmonary hypertension successfully treated without intubation

Leonce Mwizerwa, Raphael Joye, Vladimir L. Cousin, Iliona Malaspinas, Maya Bouhabib, Hugues Lucron, Maurice Beghetti, Julie WackerGeneva University Hospitals and University of Geneva. AP-HP Paris-Saclay University and Bicêtre Hospital.Switzerland and France Translational PediatricsTrans Pediatr 2025; 14: 2374-2380DOI: 10.21037/tp-2025-264 AbstractBackground: Prenatal closure of the ductus arteriosus (DA) is an uncommon but potentially severe condition that can result in

Two case reports of idiopathic prenatal closure of the ductus arteriosus complicated at birth by severe pulmonary hypertension successfully treated without intubation Read More »

Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia

Eric D. Austin, Mary P. Mullen, Catherine M. Avitabile, Usha S. Krishnan, Erika B. Rosenzweig, Roberta L. Keller, John P. Kinsella, Delphine Yung, Lea Steffes, Angela Bates, Eleni G. Elia, Lewis H. Romer, Sharon McGrath-Morrow, Meghan L. Bernier, Kenneth D. Mandl, J.Usha Raj, Lynn A. Sleeper, Steven H. AbmanVanderbilt University Medical Center. Boston Children’s Hospital

Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia Read More »

Part 8: Pediatric Advanced Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Javier J. Lasa, Gurpreet S. Dhillon, Jonathan P. Duff, Jennifer Hayes, Beena D. Kamath-Rayne, Arielle Levy, Melissa Mahgoub, Ryan W. Morgan, Taylor McCormick, Joan S. Roberts, Catherine E. Ross, Stephen M. Schexnayder, Todd Sweberg, Santiago O. Valdés, Alexis A. TopjianChildren’s Health Systems of Texas and UT Southwestern Medical Center. Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine. Lucile Packard Children’s Hospital and Stanford Medical Center. University of Alberta and Stollery Children’s Hospital. Children’s Hospital Orange County. American Academy of Pediatrics.

Part 8: Pediatric Advanced Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Read More »

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