Medical Therapy. Efficacy or Lack of Efficacy

Neonatal early-onset sepsis caused by Streptococcus Gallolyticus subsp. Pasteurianus with severe pulmonary hypertension and leukemoid reaction: a case report

Xuelian Wang, Ling Wang, Yuan Yuan, Xiaopeng Zhao, Huayan ZhangGuangzhou Women and Children’s Medical Center and Guangzhou Medical University. Children’s Hospital of Philadelphia.China and United States BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-06026-4 AbstractBackground: Streptococcus gallolyticus subsp. pasteurianus (SGSP) is an uncommon cause of neonatal early-onset sepsis (EOS). We present a case of neonatal EOS attributed […]

Neonatal early-onset sepsis caused by Streptococcus Gallolyticus subsp. Pasteurianus with severe pulmonary hypertension and leukemoid reaction: a case report Read More »

Efficacy and safety of treprostinil in pediatric pulmonary hypertension following fontan surgery: a real-world analysis

Mingjie Zhang, Xi Chen, Yahe Xu, Yijun Chen, Zhiyue Zhang, Jingru Zhou, Zhuoming XuShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. China BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-06097-3 AbstractIntroduction: This study aimed to evaluate the efficacy and safety of treprostinil in managing pulmonary hypertension (PH) following Fontan surgery in children. The

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Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

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Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies

Tamara M. Hundscheid, Ilaria Amodeo, Giacomo Cavallaro, Carlijn R. Hooijmans, František Bartoš, Eduardo VillamorMosaKids Children’s Hospital and Maastricht University Medical Center. Clínica Universidad de Navarra. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Radboud University Medical Center. University of Amsterdam.Netherlands, Spain and Italy BiomedicinesBiomed 2025; 13: DOI: 10.3390/biomedicines13092274 AbstractBackground: In congenital diaphragmatic hernia (CDH), pulmonary hypoplasia and

Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies Read More »

Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease

Melissa J. Lucero, Christina Lisk, Delaney Swindle, Francesca Cendali, Saini Setua, Kiruphagaran Thangaraju, Alamzeb Khan, David I. Pak, Quintin O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Saqib Khan, Nishant Rana, Natalie Westover, Pavel Davizon-Castillio, Gemlyn George, Kathryn Hassell, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Christy Niemeyer, Pedro Cabrales, Andre Palmer, Angelo D’Alessandro, Paul W. Buehler,

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Pre-existing pulmonary arterial hypertension decompensation associated with e-cigarettes in an adolescent

James Andrew Bishara, Patrick EversOregon Health and Science University and Doernbecher Children’s Hospital.United States Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125100577 AbstractAn adolescent girl with a long-standing history of pulmonary arterial hypertension experienced severe clinical decompensation after starting to use e-cigarettes. A combination of e-cigarette cessation, atrial septostomy, increasing treprostinil, and initiation of sotatercept led

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Efficacy and Safety of Pulmonary Vasodilator and Inodilator Drugs in Congenital Heart Disease Surgery: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Martina Ollosu, Vincenzo Francesco Tripodiy, Carlotta Aresu, Giammarco Ledda, Francesca Manai, Chiara Marini, Mario Musu, Mariachiara Ippolitoz, Andrea Cortegianiz, Gabriele Finco, Salvatore SardoUniversity of Cagliari. “Gaetano Martino” University Hospital. University Hospital Policlinico Paolo Giaccone. Italy Journal of Cardiothoracic and Vascular AnesthesiaJ Cardiothorac Vasc Anesth 2025; DOI: 10.1053/j.jvca.2025.08.053 AbstractBackground: Perioperative management of congenital heart disease (CHD) surgery presents

Efficacy and Safety of Pulmonary Vasodilator and Inodilator Drugs in Congenital Heart Disease Surgery: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Read More »

Use of Dupilumab to Treat Cutaneous Complications of Continuous Prostacyclin Infusion in Pulmonary Hypertension: A Case Report and Review of Literature

Nidhy P. Varghese, Erin Ely, Rozmeen Fombin, Claire Champion, Elise WhalenBaylor College of Medicine and Texas Children’s Hospital.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70158 AbstractAdhesive reactions are common complications of continuous treprostinil infusions, limiting their recommended use as a treatment for severe pulmonary hypertension. We present the case of a 10-year-old male with recurrent

Use of Dupilumab to Treat Cutaneous Complications of Continuous Prostacyclin Infusion in Pulmonary Hypertension: A Case Report and Review of Literature Read More »

Nebulized Treprostinil in Mechanically Ventilated Children

Sarah P. Cohen, Diane Paulus, Ashley Hattie, Beth Malehorn, Mary Irmen, Robert GajarskiOhio State University and Nationwide Children’s Hospital. United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71278 AbstractAbstract Not Available CategoryMedical Therapy. Efficacy or Lack of EfficacyMedical Therapy. Adverse Effects or Lack of Adverse EffectsMedical Therapy. Pharmacokinetics and Pharmacology Age Focus: Pediatric Pulmonary Vascular Disease

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Respiratory Outcomes Following Late Postnatal Dexamethasone Administration in Preterm Infants With Bronchopulmonary Dysplasia

Melissa House, James Rowe, Audrey Walters, Chunyan Liu, Shelley R. Ehrlich, Thomas Nienaber, Erik B. Hysinger, Paul Kingma, Shawn K. AhlfeldEmory University School of Medicine and Children’s Healthcare of Atlanta. Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71275 AbstractObjective: To wean respiratory support, preterm infants

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