Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen, Anton Vonk Noordegraaf, Peter ten Dijke, Rudolf A. de Boer, Harm Jan Bogaard, Marie José Goumans, Rolf M. F. BergerLeiden University Medical Center. University of Groningen and Beatrix Children’s Hospital. Vrije Universiteit Amsterdam. University of Groningen and University Medical Center Groningen.Netherlands AngiogenesisAngiogenesis 2022; 25: 99-112DOI: 10.1007/s10456-021-09812-7 AbstractPulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure […]

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G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Charifa Awada, Alice Bourgeois, Sara-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jevaseelan, Steeve ProvencherCentre de recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec. Janssen Research and Development. Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2023; DOI: 10.1165/rcmb.2022-0300OC AbstractPulmonary

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Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia

Nzali V. Campbell, Claudia Mickael, Sushil Kumar, Hui Zhang, Ian L. Campbell, Austin E. Gillen, Caio O. Trentin, Katrina Diener, Bifeng Gao, Vitaly O. Kheyfets, Sue Gu, Rahul Kumar, Tzu Phang, R. Dale Brown, Brian B. Graham, Kurt R. StenmarkUniversity of Colorado. Stanford University. University of California San Francisco.United States American Journal of Physiology Lung

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The vascular phenotype of BPD: new basic science insights-new precision medicine approaches

Wojciech Durlak, Bernard ThébaudUniversity of Ottawa. Jagiellonian University Medical College. Poland and Canada Pediatric ResearchPediatr Res 2022; DOI: 10.1038/s41390-022-02428-7 AbstractBronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Up to 1/3 of children with BPD develop pulmonary hypertension (PH). PH increases mortality, the risk of adverse neurodevelopmental outcome and lacks effective treatment. Current vasodilator

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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target

Stephen L. Archer, Glenn Marsboom, Gene H. Kim, Hannah J. Zang, Peter T. Toth, Eric C. Svensson, Jason R. B. Dyke, Mardi Gomberg-Maitland, Bernard Thébaud, Aliya N. Husain, Nicole Cipriani, Jalees RehmaneUniversity of Chicago. University of Alberta.United States and Canada CirculationCirculation 2010; 121: 2661-2671DOI: 10.1161/CIRCULATIONAHA.109.916098 AbstractBackground: Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle

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Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension

Lingli Wang, Jan Renier Moonen, Aigin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pi-I. Chen, Mingxia Xu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, YuMee Kim, Kryn Stankunas, Marlene RabinovitchStanford University School of Medicine, Howard Hughes Medical Institute, and Lucille Packard Children’s HospitalUnited States Circulation ResearchCirc Res 2023;

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Synchrotron-based phase-contrast micro-CT as a tool for understanding pulmonary vascular pathobiology and the 3-D microanatomy of alveolar capillary dysplasia

Christian Norvik, Christian Karl Westöö, Niccolò Peruzzi, Goran Lovric, Oscar van der Have, Rajmund Mokso, Ida Jeremiasen, Hans Brunnström, Csaba Galambos, Martin Bech, Karin Tran-LundmarkLund University. École Polytechnique Fédérale de Lausanne. Swiss Light Source. University of Colorado.Sweden, Switzerland and United States American Journal of Physiology Lung cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol

Synchrotron-based phase-contrast micro-CT as a tool for understanding pulmonary vascular pathobiology and the 3-D microanatomy of alveolar capillary dysplasia Read More »

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