Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease Archives - Page 2 of 16

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α

Amanda Czerwinski, Paul Sidlowski, Emily Mooers, Yong Liu, Ru-Jeng Teng, Kirkwood Pritchard Jr., Xigang Jing, Suresh Kumar, Amy Y. Pan, Pengyuan Liu, Girija G. Konduri, Adeleye AfolayanMedical College of Wisconsin. University of Arizona College of Medicine. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0353OC AbstractHypoxia-inducible factors […]

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α Read More »

Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome

Fabien Robert, Feriel Benchenouf, My Ngoc Ha, Alessandra Cuomo, Mina Ottaviani, Maxime Surbier, Raphaël Thuillet, Corinne Normand, Florent Dumont, Céline Verstuyft, Frederic Fiore, Frederic Guinut, Marc Humbert, Audrey Coilly, Emmanuel Gonzales, Olivier Sitbon, Ly Tu, Christophe Guignabert, Laurent SavaleUniversité Paris-Saclay. Federico II University. Aix Marseille Université. Hôpital Bicêtre. Hôpital Paul Brousse. France and Italy JHEP

Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome Read More »

RNA-Seq and ChIP-Seq Identification of Unique and Overlapping Target Genes and Pathways Regulated by TBX4 in Human Pulmonary Fibroblasts and Pericytes

Ying Cai, Ling Yan, James West, Joy D. Cogan, Lora K. Hedges, Bethany Nunley, Nick Negretti, Jennifer M. S. Sucre, Eric D. Austin, Rizwan HamidVanderbilt University Medical Center Nashville. Biodevelopment Origins of Lung Disease (BOLD) Center. United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70058 AbstractTranscription factor TBX4 rare variants associate with pulmonary arterial hypertension (PAH), particularly in

RNA-Seq and ChIP-Seq Identification of Unique and Overlapping Target Genes and Pathways Regulated by TBX4 in Human Pulmonary Fibroblasts and Pericytes Read More »

Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism

Jingyuan Chen, Xinping Chen, Vineet Agrawal, Christy S. Moore, Tom Blackwell, Nivedita Rathaur, Santhi Gladson, Anandharajan Rathinasabapathy, Anna Hemnes, Eric Austin, James WestVanderbilt University Medical Center. Second Xiangya Hospital of Central South University. Wistar Institute.United States and China Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70054 AbstractFemale sex increases risk of Group I pulmonary arterial hypertension by

Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism Read More »

An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension

Ram Raj Prasad 1, Sushil Kumar 1, Hui Zhang 1, Min Li 1, Cheng-Jun Hu 2, Suzette Riddle 1, Brittany A McKeon 3, M G Frid 1, Konrad Hoetzenecker 4, Slaven Crnkovic 5, Grazyna Kwapiszewska 5, Rubin M Tuder 1, Kurt R Stenmark 1 University of Colorado Anschutz Medical Campus. Medical University of Vienna. Medical University of Graz.United States and Austria Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.184141 AbstractThe complement system is central to the innate immune response, playing

An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension Read More »

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Manivannan Yegambaram, Anlin Feng, Yishu Dong, Saurabh Aggarwal, Hoshang J. Unwalla, Jeffrey R. Fineman, Stephen M. Black, Ting WangFlorida International University. University of California, San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26031352 AbstractPulmonary arterial hypertension (PAH) is characterized by increased lung

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling Read More »

A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension

Lan Zhao, Christine M. Cunningham, Jason Hong, Stuti Agarwal, Ke Yuan, Vinicio A. de Jesus Perez, Mark R. NicollsStanford University. University of California, Los Angeles. Boston Children’s Hospital.United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0410OC AbstractPulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular

A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension Read More »

TGFBI regulates pulmonary vascular remodeling through endothelial-to-mesenchymal transition in pulmonary arterial hypertension

Da Eun Roh, Na Rae Park, Bo Geum Choi, Youra Kang, Jung-Eun Kim, Yeo Hyang KimKyungpook National University, Kyungpook National University Children’s Hospital and Kyungpook National University Hospital. Republic of Korea Biochemical and Biophysical Research CommunicationsBiochem Biophys Res Commun 2025; 751: DOI: 10.1016/j.bbrc.2025.151435 AbstractPulmonary arterial hypertension (PAH) is a progressive disorder characterized by elevated pulmonary artery

TGFBI regulates pulmonary vascular remodeling through endothelial-to-mesenchymal transition in pulmonary arterial hypertension Read More »

MiR-25-3p regulates pulmonary arteriovenous malformation after Glenn procedure in patients with univentricular heart via the PHLPP2-HIF-1α axis

Junpei Kawamura, Munekazu Yamakuchi, Kentaro Ueno, Teruto Hashiguchi, Yasuhiro OkamotoKagoshima University. Japan Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-88840-5 AbstractThe detailed mechanism of pulmonary arteriovenous malformations after Glenn surgery (G-PAVMs) in cyanotic congenital heart disease (CHD) remains unclear. Microarray in situ hybridization was performed to assess the miRNA (miRNA) profiles of serum from pediatric patients (0-6

MiR-25-3p regulates pulmonary arteriovenous malformation after Glenn procedure in patients with univentricular heart via the PHLPP2-HIF-1α axis Read More »