Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior

Laura Yuriko González-Teshima, Keisuke Hakamada, Kozue Murata, Reiko Nakagawa, Shiro Baba, Yujiro Ide, Maiko Okamura, Akio Ikai, Tadashi Ikeda, Kenji Minatoya, Masaya Hagiwara, Masaya Ikegawa, Hidetoshi MasumotoKyoto University Graduate School of Medicine. RIKEN Center for Biosystems Dynamics Research. Doshisha University. Shizuoka General Hospital. Japan Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-25523-1 AbstractPulmonary arteriovenous malformations (PAVM) are […]

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Exploring the Impact of Platelet-Derived Growth Factor D in Pulmonary Hypertension Development

Philip Tannenberg, Karin Tran‐Lundmark, Ya‐Ting Chang, Hanna Gladh, Frank Chenfei Ning, Christian Westöö, Christian Norvik, Azra Alajbegovic, Sebastian Albinsson, Hans Brunnström, Ulf Hedin, Erika FolestadKarolinska Institutet Stockholm. Skane University Hospital and Lund University. Chang Gung Memorial Hospital.Sweden and Taiwan Pulmonary CirculationPulm Circ 2025; 22: DOI: 10.1002/pul2.70216 AbstractPulmonary arterial hypertension (PAH) is a life-threatening condition with no

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Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension

Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils-Bonnet, Martin Wabitsch, Margaret R. MacLeanUniversity of Strathclyde. Queen Mary University of London. Medical University of Vienna. University of Edinburgh. Laval University. Ulm University Medical Center.United Kingdom, Austria, Canada and Germany

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Downregulation of KLF2 impairs pulmonary endothelial function and promotes persistent pulmonary hypertension of the newborn

Ningning Chen, Xiaohang Yin, Dong Wang, Dongmei Zhou, Lili Kang, Xiaoying LiChildren’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital), Cheeloo College of Medicine and Shandong University. China Biochemical PharmacologyBiochem Pharmacol 2025; DOI: 10.1016/j.bcp.2025.117572 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a severe and progressive disorder with limited therapeutic options. Dysfunction of pulmonary artery endothelial

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Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway

Zongbin Li, Miao Zhao, Shanshan Ma, Shuyu LeiThird People’s Hospital of Xinjiang Uygur Autonomous Region. China European Journal of Medical ResearchEur J Med Res 2025; DOI: 10.1186/s40001-025-03586-0 AbstractBackground: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) drives lethal pulmonary vascular remodeling. While circular RNAs (circRNAs) are emerging as disease regulators, their functional roles in PAH-CHD remain

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway Read More »

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage

He Zhang, Sixie Zheng, Zheng Wang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Yiting Xue, Junhua Wu, Sijuan Sun, Lincai YeAffiliated Women and Children’s Hospital of Ningbo University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China Cell

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Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications

Xiaoyu Zhang, Liming Cheng, Jiahui Xie, Xuejuan Ma, Wenting Gui, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Kunming Children’s Hospital, Chinese Academy of Medical Sciences and Affiliated Cardiovascular Hospital of Kunming Medical University. China Frontiers in PhysiologyFront Physiol 2025; 14: DOI: 10.3389/fphys.2025.1673181 AbstractBackground: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling

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Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat

Bingbing Ye, Danyan Su, Yuqin Huang, Dongli Liu, Yanyun Huang, Suyuan Qin, Cheng Chen, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University.China Clinical and Experimental HypertensionClin Exp Hypertens 2025; 47: DOI: 10.1080/10641963.2025.2583193 AbstractThis study was designed to elucidate the role of circPcmtd1 in regulating pulmonary artery smooth muscle cells (PASMCs) proliferation and migration, through the HSP90AB1/AKT

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat Read More »

Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation

Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin, Hui LiSecond Affiliated Hospital, Yuying Children’s Hospital and Wenzhou Medical University. China Lipids in Health and DiseaseLipids Health Dis 2025; 24:DOI: 10.1186/s12944-025-02746-9 AbstractPulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased

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Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension

Christine L. Farrell, Mariah Jordan, Janelle N. Posey, Kimberly R. Jordan, Aneta Gandjeva, Eva S. Nozik, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of California San Francisco.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70174 AbstractUsing lung immunohistochemistry and stereology, platelets

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