Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C.U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwartzHarper Cancer Research Institute. University of Notre Dame. Indiana University School of Medicine. United States Circulation ResearchCirc Res 2023; DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension […]

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology

Chien-Nien Chen, Nabil Hajji, Fu-Chiang Yeh, Sunniyat Rahman, Souad Ali, John Wharton, Nicoleta Baxan, Lin Zhao, Chong-Yang Xie, Yi-Guan Chen, Maria G. Frid, Prakash Chelladurai, Soni Savai Pullamsetti, Kurt R. Stenmark, Martin R. Wilkins, Lan ZhaoImperial College London. Tri-Service General Hospital. University of Colorado. University Giessen Lung Centre. Max Planck Institute for Heart and Lung

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology Read More »

The emerging roles of SUMOylation in pulmonary diseases

Xuyang Zheng, Lingqiao Wang, Zhen Zhang, Huifang TangThe Affiliated Hangzhou First People’s Hospital, Zhejiang Respiratory Drugs Research Laboratory and Zhejiang University School of Medicine. China Molecular MedicineMol Med 2023; 29: DOI: 10.1186/s10020-023-00719-1 AbstractSmall ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair,

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Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture

Hanadi Almazroue, Yi Lin, Leif D. Nelin, John C. Barba II, Avante D. Milton, Jennifer K. TrittmannAbigail Wexner Research Institute at Nationwide Children’s Hospital. The Ohio State University College of Medicine.United States American Journal of Physiol Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L360-L367DOI: 10.1152/ajplung.00433.2021 AbstractBronchopulmonary dysplasia (BPD) is the

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Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph KnosallaDeutsches Herzzentrum der Charité. Charité-Universitätsmedizin Berlin. Freie Universität Berlin and Humboldt-Universität zu

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Metabolomic differences in connective tissue disease-associated versus idiopathic pulmonary arterial hypertension in the PVDOMICS cohort

Catherine E. Simpson, Anna R. Hemnes, Megan Griffiths, Gabriele Grunig, W. H. Wison Tang, Joe G. N. Garcia, John Barnard, Suzy A. Comhair, Rachel L. Damico, Stephen C. Mathai, Paul M. Hassoun, the PVDOMICS Study GroupJohns Hopkins University. Vanderbilt University. University of Texas Southwestern Medical Center. New York University Grossman School of Medicine. Cleveland Clinic.

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Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia

Krithika Lingappan, Oluyinka O. Olutoye II, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. KeswaniChildren’s Hospital of Philadelphia. Baylor College of Medicine and Texas Children’s Hospital. University of Delaware. United States American Journal of Physiology Lung Cellular and

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SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Min Li, Lydie Plecita-Hlavata, Evgenia Dobrinskikh, B. Alexandre McKeon, Aneta Gandjeva, Suzette Riddle, Aya Laux, Ram Raj Prasad, Sushil Kumar, Rubin M. Tuder, Hui Zhang, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado Denver – Anschutz Medical Campus. Czech Academy of Sciences. United States and Czech Republic American Journal of Respiratory Cell and Molecular BiologyAm J

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Metabolic Deregulation in Pulmonary Hypertension

Rajamma Mathew, Sanda Iacobas, Jing Huang, Dumitru Andrei IacobasNew York Medical College. Rutgers University Biomedical and Health Sciences. Prairie View A&M University.United States Current Issues in Molecular BiologyCurr Issues Mol Biol 2023; 45: 4850-4874DOI: 10.3390/cimb45060309 AbstractThe high morbidity and mortality rate of pulmonary arterial hypertension (PAH) is partially explained by metabolic deregulation. The present study complements

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Metabolic reprogramming, oxidative stress, and pulmonary hypertension

Marissa D. Pokharel, David P. Marciano, Panfeng Fu, Maria Clara Franco, Hoshang Unwalla, Kim Tieu, Jeffrey R. Fineman, Ting Wang, Stephen M. BlackFlorida International University.  University of California San Francisco. United States Redox BiologyRedox Biol 2023; DOI: 10.1016/j.redox.2023.102797 AbstractMitochondria are highly dynamic organelles essential for cell metabolism, growth, and function. It is becoming increasingly clear that

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