Right Heart Dysfunction Associated with Pulmonary Vascular Disease

The biventricular contribution to chronic pulmonary hypertension of the extremely premature infant

Gabriela de Carvalho Nunes, Punnanee Wutthigate, Jessica Simoneau, Adrian Dancea, Marc Beltempo, Claudia Renaud, Gabriel AltitMcGill University Health Centre and Montreal Children’s Hospital. Siriraj Hospital and Mahidol University. Canada and Thailand Journal of PerinatologyJ Perinatol 2023; 43: 174-180DOI: 10.1038/s41372-022-01497-0 AbstractObjective: Evaluate factors associated with significant pulmonary hypertension [PH] (≥2/3 systemic) and its impact on ventricular function at […]

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A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops

Manuel J. Richter, Athiththan Yogeswaran, Faeq Husain-Sved, Istvan Vadasc, Zvomimir Rako, Emad Mojajerani, Hossein A. Ghofrani, Robert Naeije, Werner Seeger, Ulrike Herberg, Andreas Rieth, Ryan J. Tedford, Friedrich Grimminger, Henning Gall, Khodr TelloJustus-Liebig-University Giessen. Kerckhoff Heart, Rheuma and Thoracic Center. Imperial College London. Erasme University Hospital. University of Bonn. Medical University of South Carolina. Germany,

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Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

Ruaa Al-Qazaz, Patricia D. A. Lima, Sasha Z. Prisco, Francois Potus, Asish Dasgupta, Kuang-Hueih Chen, Lian Tian, Rachel E. T. Bentley, Jeff Mewburn, Ashley Y. Martin, Danchen Wu, Oliver Jones, Donald H. Maurice, Sebastien Bonnet, Steeve Provencher, Kurt W. Prins,Stephen L. ArcherQueen’s University. University of Minnesota Medical School. Laval University. University of Strathclyde.Canada, United States

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Full recovery of right ventricular systolic function in children undergoing bilateral lung transplantation for severe PAH

Georg Hansmann, Franziska Diekmann, Philippe Chouvarine, Fabio Ius, Julia Carlens, Nicolaus Schwerk, Gregor Warnecke, Jens Vogel-Claussen, Dagmar Hohmann, Tim Alten, Thomas JackEuropean Pediatric Pulmonary Vascular Disease Network. Hannover Medical School. University Hospital Heidelberg.Germany Journal of Heart and Lung TransplantationJ Heart Lung Transplant 2022; 41: 187-198DOI: 10.1016/j.healun.2021.10.014 AbstractBackground: We investigated whether RV function recovers in children with pulmonary

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Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients

Ali Ahmadi, Jennifer M. Renaud, Steven Promislow, Ian G. Burwash, Girish Dwivedi, Ran Klein, Jason G. E. Zelt, Robert A. deKamp, Rob S. Beanlands, Lisa M. MielniczukUniversity of Ottawa.Canada Journal of Nuclear CardiologyJ Nucl Cardiol 2021; 28: 2784-2795DOI: 10.1007/s12350-020-02144-x AbstractBackground: Reduced left ventricular (LV) function is associated with increased myocardial oxygen consumption rate (MVO2) and altered sympathetic

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Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

Jason G. E. Zelt, Virgilio Cadete, Yupu Deng, Rafael Godoy, Alexanne Cuillerier, Katelynn Rowe, Mohammad Abdul-Ghani, Lynn Megeney, Yan Burelle, Antonio Giulivi, Alexandre F. R. Stewart, Steeve Provencher, Sandra Breuils-Bonnet, Sébastien Bonnet, Robert deKemp, Rob Beanlands, Lisa M. Mielniczuk, Duncan J. StewartUniversity of Ottawa.Canada HypertensionHypertension 2022; 79: 2774-2786DOI: 10.1161/HYPERTENSIONAHA.122.19300 AbstractBackground: We explored the mechanism of maladaptive right

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Right ventriculo-pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension

Toshitaka Nakaya, Hiroshi Ohira, Takahiro Sato, Taku Watanabe, Masaharu Nishimura, Noriko Oyama-Manabe, Masaru Kato, Yoichi M. Ito and Ichizo TsujinoHokkaido University Hospital. The Institute of Statistical Mathematics.Japan Pulmonary CirculationPulm Circ 2020; 10: DOI: 10.1177/2045894020957223 AbstractRight ventricular function critically affects the prognosis of patients with pulmonary arterial hypertension. We aimed to analyze the prognostic value of right

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Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension

Paul J. Critser, Debra Boyer, Gary A. Visner, Shane L. Collins, Mary P. MullenHarvard University and Boston Children’s Hospital.United States Pediatric TransplantationPediatr Transplant 2022; 26: e14236DOI: 10.1111/petr.14236 AbstractBackground: Lung transplantation is a therapeutic option for end-stage pediatric pulmonary hypertension (PH). Right ventricular (RV) recovery post-lung transplant in children with PH has not been well-described, and questions persist

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The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension

Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. GrahamUniversity of Colorado. University of California San Francisco.United States Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12105 AbstractRight ventricular (RV) failure is the primary cause of death in pulmonary

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Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study

Rachelle Walter, Kendall Hunter, Kurt Stenmark, Vitaly O. KheyfetsUniversity of ColoradoUnited States Journal of Biomechanical EngineeringJ Biomech Eng 2022; 144: DOI: 10.1115/1.4051719 AbstractPulmonary hypertension (PH) is a progressive disease that is characterized by a gradual increase in both resistive and reactive pulmonary arterial (PA) impedance. Previous studies in a rodent model of PH have shown that

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