Heart Dysfunction Associated with Pulmonary Vascular Disease

Characterization of Intracardiac Flow in the Right Ventricle With Pressure and Volume Overload in Children

Yasunobu Hayabuchi, Yukako HommaTokushima University.Japan Cardiology ResearchCardiol Res 2025; 16: 22-32DOI: 10.14740/cr2009 AbstractBackground: Blood flow visualization using vector flow mapping (VFM) holds potential as a novel indicator of right ventricular (RV) function.Methods: This study included 12 patients with atrial septal defect (ASD group, mean (± standard deviation) age: 6.2 ± 1.5 years), six patients with pulmonary hypertension (PH

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Novel Therapies for Right Ventricular Failure

Bibhuti B. DasUniversity of Mississippi Medical Center.United States Current Cardiology ReportsCurr Cardiol Rep 2025; 27:DOI: 10.1007/s11886-024-02157-9 AbstractPurpose of review: Traditionally viewed as a passive player in circulation, the right ventricle (RV) has become a pivotal force in hemodynamics. RV failure (RVF) is a recognized complication of primary cardiac and pulmonary vascular disorders and is associated with a

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Mortality Patterns in Pediatric Pulmonary Vein Stenosis: Insights Into Right Ventricular Systolic Pressure Associations

Daiji Takajo, Paul J. Critser, Michelle Cash, Melissa Magness, Russel HirschCincinnati Children’s Hospital Medical Center and University of Cincinnati.United States Journal of the American Heart AssociationJ Am Heart Assoc 2025; DOI: 10.1161/JAHA.124.037908DOI: 10.1161/JAHA.124.035037 (correction) AbstractBackground: Pulmonary vein stenosis in children is associated with a poor prognosis. However, the cause and risk factors for mortality remain uncertain.Methods: This retrospective, single-center

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Pediatric Pulmonary Arterial Hypertension; is it Possible to Predict its Outcome?

Hala M. Aghaa, Ranya Hegazy, Ahmed Gamal, Ranya Essam, Antoine A. Elmessih, Ahmed Behairy,Nagib Dahdah, Ahmed Abdelwahed, Nesrine Sobhy, Noha AliSpecialized Pediatric Hospital and Cairo University. CHU Sainte Justine and University of Montreal.Egypt and Canada Journal of the Saudi Heart AssociationJ Saudi Heart Assoc 2024; 36: 408-419DOI: 10.37616/2212-5043.1398 AbstractObjectives: To assess the outcome of pediatric pulmonary arterial

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Use of Right Ventricular Free-Wall Strain in a Multivariable Estimate of Right Ventricular-Arterial Coupling in Pediatric Pulmonary Arterial Hypertension

Charles T. Simpkin, D. Dunbar Ivy, Mark K. Friedberg, Dale A. BurkettChildren’s Hospital Colorado and University of Colorado – Anschutz Medical Campus. Hospital for Sick Children and University of Toronto.United States and Canada Circulation Cardiovascular ImagingCirc Cardiovasc Imag 2024; DOI: 10.1161/CIRCIMAGING.124.016882 AbstractBackground: Right ventricular-arterial coupling (RVAC) describes the relationship between right ventricular contractility and pulmonary vascular afterload.

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Echocardiographic Changes in Infants with Severe Congenital Diaphragmatic Hernia After Fetoscopic Endoluminal Tracheal Occlusion (FETO)

Catherine M. Avitabile, Sabrina Flohr, Leny Mathew, Yan Wang, Devon Ash, Juliana S. Gebb, Natalie E. Rintoul, Holly L. HedrickUniversity of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia. United States Pediatric CardiologyPediatr Cardiol 2024; DOI: 10.1007/s00246-024-03735-y AbstractFetoscopic endoluminal tracheal occlusion (FETO) induces lung growth and may improve survival in congenital diaphragmatic hernia (CDH)

Echocardiographic Changes in Infants with Severe Congenital Diaphragmatic Hernia After Fetoscopic Endoluminal Tracheal Occlusion (FETO) Read More »

Asymmetric right ventricular myocardial work correlates with gold standard measurements of cardiac function in pulmonary hypertension

Simone G. Diab, Ryota Ebata, Dariusz Mroczek, Wei Hui, Espen W. Remme, Thomas Möller, Mark K. FriedbergOslo University Hospital and University of Oslo. Chiba University. Hospital for Sick Children.Norway and Japan Pulmonary CirculationPulm Circ 2024; 14: DOI: 10.1002/pul2.70014 AbstractRight ventricular (RV) (dys)function determines outcomes in pulmonary hypertension (PH). We previously found that asymmetric RV myocardial work

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Ventricular Dysfunction in Patients With Congenital Diaphragmatic Hernia Who Die After Repair

Catherine M. Avitabile, Yang Wang, Devon Ash, Sabrina J. Flohr, Leny Mathew, Natalie Rintoul, Holly L. HedrickPerelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia. United States Journal of Pediatric SurgeryJ Pediatr Surg 2024; 60: DOI: 10.1016/j.jpedsurg.2024.162002 AbstractBackground: Quantitative echocardiographic (echo) measures of ventricular function predict mortality in pediatric pulmonary hypertension (PH),

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Utility of urinary NT-proBNP in congenital diaphragmatic hernia: a prospective pilot study

Srirupa Hari Gopal, Kelly Frances Martinek, Candice Vacher, Judith Becker, Nighy P. Varghese, Betul Yilmaz Furtun, Joseph L. Hagan, Sharada H. Gowda, Mohan Pammi, Sridevi Devaraj, Caraciolo J. FernandesBaylor College of Medicine.United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03600-x AbstractBackground: Echocardiography is the reference standard for diagnosing pulmonary hypertension (PH) and cardiac dysfunction (CD) in congenital diaphragmatic

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A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

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