Heart Dysfunction Associated with Pulmonary Vascular Disease

Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with […]

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Pediatric heart failure: A focus on low-income countries

Sulafa Km AliUniversity of Sharjah.United Arab Emirates World Journal of Clinical PediatricsWorld J Clin Pediatr 2026; 15: DOI: 10.5409/wjcp.v15.i2.115168 AbstractHeart failure (HF) in the pediatric population is unique because it involves heterogeneous groups of diseases, including congenital and acquired conditions. The etiology of HF varies with age and sociodemographic origin. In low-income countries, unoperated congenital heart

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Case Report: Post-Total anomalous pulmonary venous connection pulmonary hypertension – novel treatment using sirolimus and atrial flow regulator implantation

Stasa Krasic, Antony Hermuzi, Ivan Dizdarevic, Vesna Topic, Nevena Djorovic, Mihail Basa, Vladislav VukomanovicMother and Child Health Institute of Serbia and University of Belgrade. Freeman Hospital and Newcastle upon Tyne Hospitals NHS Foundation Trust. Serbia and United Kingdom Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13: DOI: 10.3389/fcvm.2026.1783773 AbstractObjective: In patients who have undergone surgical repair of

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Clinical Utility and Limitations of TAPSE in Pediatric Echocardiography: A Narrative Review

Matei Mselle, Ronald MbwasiHaydom Lutheran Hospital. Kilimanjaro Christian Medical Centre and Kilimanjaro Christian Medical University.Tanzania EchocardiographyEchocardiography 2026; 43: DOI: 10.1111/echo.70516 AbstractBackground: Tricuspid annular plane systolic excursion (TAPSE) is widely used to assess right ventricular (RV) longitudinal systolic function in pediatric echocardiography; however, its reliability is influenced by developmental physiology.Objective: To evaluate the clinical utility, age-dependent variability, and limitations

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Echocardiographic Detection of Pulmonary Hypertension and Right Ventricular Failure in Infants with Bronchopulmonary Dysplasia: A Survey of the BPD Collaborative

Shilpa Vyas-Read, Shazia Bhombal, Roopa Siddaiah, Clifford L. Cua, Amulya Buddhavarapu, Robin L. McKinney, Philip T. Levy, Amanda L. Hauck, Nicolas F. M. Porta, Kathleen A. Gibbs, Krithika Lingappan, Matthew S. Douglass, Eric D. Austin, Steven H. Abman, Ronald W. DayEmory University and Children’s Healthcare of Atlanta. Arkansas Children’s Hospital. Ohio State University and Nationwide

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The Right Ventricle, the Forgotten Chamber or Not

Ranjini Srinivasan, Alessandro Castiglione, Michael Antonchak, Ellen OstenfeldWeill Cornell School of Medicine. Lund University and Skåne University Hospital. New York University Grossman School of Medicine.United States and Sweden Magnetic Resonance Imaging Clinics of North AmericaMagn Reson Imaging Clin N Am 2026; 34: 217-230DOI: 10.1016/j.mric.2026.01.011 AbstractRight ventricular (RV) enlargement or dysfunction evaluation is the cornerstone for diagnosis, prognostications, and treatment planning in a variety

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Metabolomics of Right Ventricular Function in Pulmonary Hypertension

Jonathan Chacon-Barahona, Samuel J Chung, Jonah D Garry, Robert Frantz, Franz Rischard, Paul M Hassoun, Stephen C Mathai, Catherine E Simpson, Gerald Beck, Nicholas S Hill, Jane A Leopold, Aaron B Waxman, Erika B Rosenzweig, Barry A Borlaug, Monica Mukherjee, Rebecca Vanderpool, Miriam Jacob, Reena Mehra, Margaret M Park, J Emanuel Finet, Samar Farha, Gabriele Grunig, Deborah Kwon, Suzy Comhair, Serpil Erzurum, John Barnard, Bo Hu, Christine L Jellis, Alexandra Christin Racanelli, Jan Krumsiek, Evan L Brittain, Anna Hemnes, Evelyn Horn; PVDOMICS Study GroupWeill Cornell Medical College. Albert

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Identification of RUNX1 as a Biomarker for Right Ventricular Remodeling in Pulmonary Arterial Hypertension Using WGCNA

Wenjie Chen, Min Peng, Yusi Chen, Jun Luo, Jingyuan Chen, Haihua Qiu, Jiang LiSecond Xiangya Hospital of Central South University. Third Xiangya Hospital Central South University.China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70297 AbstractRight ventricle (RV) dysfunction is central to pulmonary arterial hypertension (PAH) yet its molecular mechanisms remain unclear. This study aimed to identify biomarkers

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Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension

Sarah M. Nofal, Abdel‑Rahman M. El‑Mashad, Asmaa M. Elmesiry, Amany M. Abouelenain, Mostafa M. AwnyTanta University.Egypt European Journal of PediatricsEur J Pediatr 2026; 185: DOI: 10.1007/s00431-026-06864-z AbstractThe aim of this study is to investigate the effects of melatonin on the left ventricular (LV) function in persistent pulmonary hypertension of the newborn (PPHN) and to assess its

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Lifesaving Compassionate-Use of Sotatercept in a 12-Year-old With Idiopathic Pulmonary Arterial Hypertension

Weronika Pelczar‐Płachta, Rafał Surmacz, Waldemar BobkowskiPoznan University of Medical Sciences.Poland Pulmonary CirculationPulm Circ 2026; 16DOI: 10.1002/pul2.70293 AbstractPediatric idiopathic pulmonary arterial hypertension (IPAH) refractory to maximal medical therapy is associated with high morbidity and mortality, and therapeutic options remain limited. We describe a 12-year-old girl with end-stage IPAH who developed acute decompensated right heart failure despite triple

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