Heart Dysfunction Associated with Pulmonary Vascular Disease

The Right Ventricle, the Forgotten Chamber or Not

Ranjini Srinivasan, Alessandro Castiglione, Michael Antonchak, Ellen OstenfeldWeill Cornell School of Medicine. Lund University and Skåne University Hospital. New York University Grossman School of Medicine.United States and Sweden Magnetic Resonance Imaging Clinics of North AmericaMagn Reson Imaging Clin N Am 2026; 34: 217-230DOI: 10.1016/j.mric.2026.01.011 AbstractRight ventricular (RV) enlargement or dysfunction evaluation is the cornerstone for diagnosis, prognostications, and treatment planning in a variety […]

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Metabolomics of Right Ventricular Function in Pulmonary Hypertension

Jonathan Chacon-Barahona, Samuel J Chung, Jonah D Garry, Robert Frantz, Franz Rischard, Paul M Hassoun, Stephen C Mathai, Catherine E Simpson, Gerald Beck, Nicholas S Hill, Jane A Leopold, Aaron B Waxman, Erika B Rosenzweig, Barry A Borlaug, Monica Mukherjee, Rebecca Vanderpool, Miriam Jacob, Reena Mehra, Margaret M Park, J Emanuel Finet, Samar Farha, Gabriele Grunig, Deborah Kwon, Suzy Comhair, Serpil Erzurum, John Barnard, Bo Hu, Christine L Jellis, Alexandra Christin Racanelli, Jan Krumsiek, Evan L Brittain, Anna Hemnes, Evelyn Horn; PVDOMICS Study GroupWeill Cornell Medical College. Albert

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Identification of RUNX1 as a Biomarker for Right Ventricular Remodeling in Pulmonary Arterial Hypertension Using WGCNA

Wenjie Chen, Min Peng, Yusi Chen, Jun Luo, Jingyuan Chen, Haihua Qiu, Jiang LiSecond Xiangya Hospital of Central South University. Third Xiangya Hospital Central South University.China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70297 AbstractRight ventricle (RV) dysfunction is central to pulmonary arterial hypertension (PAH) yet its molecular mechanisms remain unclear. This study aimed to identify biomarkers

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Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension

Sarah M. Nofal, Abdel‑Rahman M. El‑Mashad, Asmaa M. Elmesiry, Amany M. Abouelenain, Mostafa M. AwnyTanta University.Egypt European Journal of PediatricsEur J Pediatr 2026; 185: DOI: 10.1007/s00431-026-06864-z AbstractThe aim of this study is to investigate the effects of melatonin on the left ventricular (LV) function in persistent pulmonary hypertension of the newborn (PPHN) and to assess its

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Lifesaving Compassionate-Use of Sotatercept in a 12-Year-old With Idiopathic Pulmonary Arterial Hypertension

Weronika Pelczar‐Płachta, Rafał Surmacz, Waldemar BobkowskiPoznan University of Medical Sciences.Poland Pulmonary CirculationPulm Circ 2026; 16DOI: 10.1002/pul2.70293 AbstractPediatric idiopathic pulmonary arterial hypertension (IPAH) refractory to maximal medical therapy is associated with high morbidity and mortality, and therapeutic options remain limited. We describe a 12-year-old girl with end-stage IPAH who developed acute decompensated right heart failure despite triple

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Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension

Shinichi Takatsuki, Kinjal Parikh, Mio Sato, Yuta Kawamura, Yurika Shimizu, Reiko Kawai, Dunbar IvyToho University Omori Medical Center. Inova Children’s Hospital. University of Colorado School of Medicine.Japan and United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04241-z AbstractTo determine the prognostic value of stroke volume index (SVi) in children with idiopathic and heritable pulmonary arterial hypertension (PAH).

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Relationships between lung ultrasound, chest CT, and echocardiographic findings in children with bronchopulmonary dysplasia: A multimodal imaging study

Andrea Maria Comisi, Giuseppe Fabio Parisi, Francesco Fabrizio Comisi, Salvatore Carnazzo, Pietro Sciacca, Alessandra Li Pomi, Sara Manti, Salvatore LeonardiSan Marco Hospital and University of Catania. Microcitemico Hospital “A. Cao” and University of Cagliari. University of Enna “Kore”. University of Messina. Italy Respiratory MedicineRespir Med 2026; DOI: 10.1016/j.rmed.2026.108775 AbstractThis study investigates the use of integrated imaging

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Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics

Janani Subramaniam, Venkata Jonnakuti, Scott D. Collum, Sandra Martineau, Kai-Lieh Huang, Sandra Breuils-Bonnet, Andrea L. Frump, Bindu H. Akkanti, Jayeshkumar A. Patel, Manish K. Patel, Ismael Salas de Armas, Isabella N. Lefebvre, Rajko Radovancevic, Elvin Blanco, Eric J. Wagner, Igor Gregoric, Sriram Nathan, Biswajit Kar, Steeve Provencher, Sebastien Bonnet, François Potus, Hari Krishna Yalamanchili, Harry

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Myocardial work during various right ventricle load conditions in a paediatric population

Ramona Ghenghea, Pierrick Pyra, Yves Dulac, Aitor Guitarte, Paul Vignaud, Philippe Acar, Khaled Hadeed, Clement KarsentyChildren’s Hospital, CHU Toulouse and Paul Sabatier University. France Achives of Cardiovascular DiseaseArch Cardiovasc Dis 2026; DOI: 10.1016/j.acvd.2025.11.013 AbstractBackground: Assessing right ventricular (RV) function in children is challenging, particularly in RV overload, where conventional echocardiographic indices do not account for afterload.Aims: This prospective

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Pathophysiology and prevalence of high output heart failure in group 1 pulmonary hypertension

Yogesh N V Reddy 1, Robert P Frantz 2, William R Miranda 2, Revati Varma 2, Paul M Hassoun 3, Anna R Hemnes 4, Evelyn Horn 5, Jane A Leopold 6, Franz Rischard 7, Erika B Rosenzweig 8, Nicholas S Hill 9, Serpil C Erzurum 10, Gerald J Beck 11, Samar Farha 12, J Emanuel Finet 12, Christine Jellis 12, Deborah Kwon 12, Stephen Mathai 3, Margaret Park 12, W H Wilson Tang 12, Barry A Borlaug 2; PVDOMICS Study GroupMayo Clinic. Johns Hopkins University. Vanderbilt University Medical Center. Weill Cornell Medicine. Brigham and Women’s Hospital and

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