Heart Dysfunction Associated with Pulmonary Vascular Disease

Myocardial Fibrosis in Pediatric Heart Disease: Mechanisms, Imaging Biomarkers, Clinical Consequences, and Emerging Antifibrotic Therapies

Usama Asghar, Samra Choudhry, Mahwish Jabeen, Khadija Mubashir, Ayrass Zia, Mehwish Sadique, Muhammad Jawad Wakil, Laiba MunawarShalamar Medical and Dental College. Faisalabad Medical University. Fatima Jinnah Medical University. Quaid e Azam Medical College. Al Aleem Medical College. Azra Naheed Medical College. Islam Medical and Dental College.Pakistan Cardiology in ReviewCardiol Rev 2026; DOI: 10.1097/CRD.0000000000001450 AbstractMyocardial fibrosis is increasingly recognized as a central determinant of […]

Myocardial Fibrosis in Pediatric Heart Disease: Mechanisms, Imaging Biomarkers, Clinical Consequences, and Emerging Antifibrotic Therapies Read More »

Clinical, Electrocardiographic, Biochemical, and Echocardiographic Markers for Diagnosing Cardiac Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: A Narrative Review

Solomon Tatagiri , Belinda Chan, Yogen SinghUniversity of California at Davis.United States ChildrenChildren 2026; 13: DOI: 10.3390/children13081050 AbstractBackground/Objectives: Hypoxic-ischemic encephalopathy (HIE) remains a leading cause of neonatal death and long-term neurodisability. Cardiovascular dysfunction commonly accompanies HIE and influences neurological recovery, yet it is difficult to recognize because conventional clinical signs correlate poorly with the myocardial function. This

Clinical, Electrocardiographic, Biochemical, and Echocardiographic Markers for Diagnosing Cardiac Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: A Narrative Review Read More »

Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort

Catherine M. Avitabile, Kimberly Butler, Antara Mondal, David B. Frank, Yan Wang, Devon Ash, Laura Mercer‐Rosa, Michael L. O’Byrne, Ryan CallahanUniversity of Pennsylvania, Perelman School of Medicine and Children’s Hospital of Philadelphia. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70346 AbstractPulmonary hypertension (PH) and right ventricular (RV) dysfunction increase mortality in multivessel pediatric pulmonary vein

Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort Read More »

Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients

Ya-fei Cheng, Cong-li Meng, Yi-ru Wang, Lin Chen, Ya-qun Ma, Wen-zhi Guo, Hang GuoSeventh Medical Center to Chinese PLA General Hospital. Southern Medical University.China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1842135 AbstractBackground: Orthotopic heart transplantation is the standard treatment for pediatric end-stage heart disease. Due to the wide age range and high physiological heterogeneity among pediatric

Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients Read More »

Cardiac performance and left ventricular dimensions in neonates with left-sided congenital diaphragmatic hernia before and after surgical repair

Mohamed Mahmoud Shalaby, Fatma Aboalsoud TahaTanta University.Egypt Journal of Cardiothoracic SurgeryJ Cardiothorac Surg 2026; DOI: 10.1186/s13019-026-04289-1 AbstractBackground: Congenital Diaphragmatic Hernia (CDH) is associated with significant cardiopulmonary morbidity. Pulmonary Hypertension (PH) and left ventricular (LV) dysfunction are major determinants of outcome. While the impact of CDH repair on pulmonary hemodynamics is recognized, comprehensive serial assessment of cardiac performance,

Cardiac performance and left ventricular dimensions in neonates with left-sided congenital diaphragmatic hernia before and after surgical repair Read More »

SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension

Xiao-He Xu, Yi Shen, Min Chen, Yu-Xin Miao, Lin Cheng, Yang-Han-Yue Zhao, Yang Fang, Dai-Ji Jiang, Fang Yu, Yang-Yang He, Zhuo-Yuan Xu, Li-Jun Fu, Li-Wei Wu, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Henan University. Second Affiliated Hospital, Yuying Children’s Hospital, Wenzhou Medical

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Association between hepatic vein Doppler and echocardiographic diastolic indices with invasively measured right ventricular filling pressures in pediatric pulmonary arterial hypertension

Tessa Palmeri, Wei Hui, Charles T. Simpkin, Andreea Dragulescu, Luc Mertens, Dunbar Ivy, Dale Burkett, Mark FriedbergHospital for Sick Children. University of Colorado Medical Campus.Canada and United States International Journal of CardiologyInt J Cardiol 2026; DOI: 10.1016/j.ijcard.2026.134619 AbstractBackground: Increased right ventricular filling pressures (RVFP) are associated with increased mortality risk in children with pulmonary arterial hypertension (PAH).

Association between hepatic vein Doppler and echocardiographic diastolic indices with invasively measured right ventricular filling pressures in pediatric pulmonary arterial hypertension Read More »

Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with

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Pediatric heart failure: A focus on low-income countries

Sulafa Km AliUniversity of Sharjah.United Arab Emirates World Journal of Clinical PediatricsWorld J Clin Pediatr 2026; 15: DOI: 10.5409/wjcp.v15.i2.115168 AbstractHeart failure (HF) in the pediatric population is unique because it involves heterogeneous groups of diseases, including congenital and acquired conditions. The etiology of HF varies with age and sociodemographic origin. In low-income countries, unoperated congenital heart

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Case Report: Post-Total anomalous pulmonary venous connection pulmonary hypertension – novel treatment using sirolimus and atrial flow regulator implantation

Stasa Krasic, Antony Hermuzi, Ivan Dizdarevic, Vesna Topic, Nevena Djorovic, Mihail Basa, Vladislav VukomanovicMother and Child Health Institute of Serbia and University of Belgrade. Freeman Hospital and Newcastle upon Tyne Hospitals NHS Foundation Trust. Serbia and United Kingdom Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13: DOI: 10.3389/fcvm.2026.1783773 AbstractObjective: In patients who have undergone surgical repair of

Case Report: Post-Total anomalous pulmonary venous connection pulmonary hypertension – novel treatment using sirolimus and atrial flow regulator implantation Read More »

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