Heart Dysfunction Associated with Pulmonary Vascular Disease

Cardiac function in children with congenital diaphragmatic hernia: cardiac strain at birth and at 2-5 weeks of age

Katarina Övermo Tydén, Kerstin Magnusson, Carmen Mesas Burgos, Baldvin Jonsson, Felicia NordenstamKarolinska Institutet and Karolinska University Hospital.Sweden Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1598695 AbstractIntroduction: Neonates with congenital diaphragmatic hernia (CDH) often present with pulmonary hypertension and various forms of cardiac dysfunction, affecting right or left ventricle or both. Although pulmonary hypertension typically improves over time, […]

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Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid

Yijun Chen, Qianhui Zhang, Xi Chen, Yahe Xu, Jing Guo, Jiajia Meng, Mingjie Zhang, Bo Wang, Zhuoming XuShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China International Journal of Biological MacromoleculesInt J Biol Macromol 2025; DOI: 10.1016/j.ijbiomac.2025.146018 AbstractPulmonary arterial hypertension (PAH) is marked by elevated vascular resistance, right ventricular (RV) failure, and poor

Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid Read More »

Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension

Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele MiragoliUniversity of Parma. Deutsches Herzzentrum Der Charité, Campus Virchow-Klinikum. University of Verona. University of Pavia. IRCCS Humanitas Research Hospital. Italy and

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Echo-Derived Right Ventricular Strain Identifies Pulmonary Hypertension in Pediatric Ventricular Assist Device Patients

Ryan S. Bishop, Tam T. Doan, Claudia Lara, Lindsay F. Eilers, Hari P. Tunuguntla, Joseph A. Spinner, Ricardo H. Pignatelli, Anitha Parthiban, James C. WilkinsonTexas Children’s Hospital and Baylor College of Medicine.United States American Society for Artificial Internal OrgansASAIO 2025; DOI: 10.1097/MAT.0000000000002489 AbstractIdentifying pulmonary hypertension in pediatric patients with continuous-flow ventricular assist device (cf-VAD) remains challenging,

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Juvenile Systemic Sclerosis Presenting With Severe Pulmonary Vascular Disease: ECMO Stabilization During Aggressive Therapy Resulting in a Favorable Outcome

Stephanie M. Tsoi, Shannon Cheung, Roberto Alejandro Valdovinos, Elena Amin, Hythem Nawaytou, Elizabeth Colglazier, Claire Parker, April Edwell, Susan Kim, Jeffrey R. FinemanUniversity of California San Francisco. Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70106 AbstractJuvenile systemic sclerosis (jSSc) associated pulmonary hypertension (PH) is rare, but, the leading cause of morbidity and mortality in jSSc. This is

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Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease

Darin T. Rosen, Todd M. Kolb, Stephen C. Mathai, Karthik Suresh, Rachel Damico, Steven Hsu, Ryan J. Tedford, Anna R. Hemnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman‐Rosenzweig, Franz Rischard, Robert P. Frantz, Serpil C. Erzurum, Gerald J. Beck, Nicholas S. Hill, John Barnard, Samar Farha, Gabriele Grunig, Christine Jellis, Deborah H. Kwon, Reena Mehra, Margaret M. Park, W. H. Wilson Tang, Paul M. Hassoun, Catherine E. Simpson, the PVDOMICS Study GroupJohns Hopkins University. University of Miami, Medical University of South Carolina. Vanderbilt University. Brigham and Women’s Hospital. Cornell University Medical Center. Westchester Medical Center and New

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Mechanism and Treatment of Right Ventricular Failure Due to Pulmonary Hypertension in Children

Bibhuti B. DasUniversity of Mississippi Medical Center.United States ChildrenChildren 2025; 12: DOI: 10.3390/children12040476 AbstractPulmonary hypertension (PH) is a progressive disorder characterized by obstructive changes in the pulmonary vasculature, leading to increased pulmonary vascular resistance (PVR), right ventricular (RV) strain, and eventual RV failure (RVF). Despite advancements in medical therapy, PH remains associated with significant morbidity and

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Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension

Bahram Mirani, John D. Dauz, Kana Yazaki, Neda Latifi, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergUniversity of Toronto, Ted Rogers Centre for Heart Research and Hospital for Sick Children. Beth Israel Deaconess Medical Center and Harvard Medical School. University of South Florida.Canada and United States Arteriosclerosis, Thrombosis and Vascular BiologyArterioscler,

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Reduced Right Ventricular Size and Function in Adolescents and Adults Born Preterm

Zachary W. Blair, Alvin Chandra, Gregory P. Barton, Nataly Sanchez Solano, Jarett D. Berry, Kara N. GossUniversity of Texas Southwestern Medical Center. Parkland Health. University of Texas Health Tyler. United States Journal of the American Society of EchocardiographyJ Am Soc Echocardiogr 2025; DOI: 10.1016/j.echo.2025.04.007 AbstractBackground: Adults born premature have smaller cardiac chamber sizes, and some develop right

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Right cardiac failure and pulmonary hypertension secondary to tonsil hypertrophy in a 3-year-old boy: a case report

Mehdi Berrajaa, Abdeladim Babakhouya, Mohamed El MinaouiSouss-Massa University Hospital and University Ibn Zohr. Mohammed VI University Hospital.Morocco PanAfrican Medical JournalPan Afr Med J 2025; DOI: 10.11604/pamj.2025.50.2.39678 AbstractIn children, the prevalence of obstructive sleep apnoea syndrome (OSAS) is 2 to 3%. Pulmonary hypertension-related OSAS in the context of tonsil hypertrophy is a well-documented phenomenon. However, cases combining

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