Pulmonary Vascular Pathology

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang ZhaoNorthwestern University Feinberg School of Medicine.United States Journal of Clinical Investigation InsightJCI Insight 2024; DOI: 10.1172/jci.insight.177926 AbstractPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding GCN2, General control […]

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension Read More »

G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease

Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D’Silva, Rajamma Mathew, Francesca Cendali, Angelo D’Alessandro, S. M. Shafiqul Alam, Victor Garcia, Joseph M. Miano, Sachin A. GupteNew York Medical College. University of Colorado Anschutz Medical Campus. Medical College of Georgia at Augusta University. United States Journal of the American Medical AssociationJ Am Heart Assoc 2024; DOI: 10.1161/JAHA.123.035174 AbstractBackground: G6PD (glucose-6-phosphate-dehydrogenase) is a key enzyme in the glycolytic pathway and has been implicated in the pathogenesis of cancer

G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease Read More »

Unraveling the Mfn2-Warburg effect nexus: a therapeutic strategy to combat pulmonary arterial hypertension arising from catch-up growth after IUGR

Lingling Yan, Xiaofei Luo, Chengcheng Hang, YuWang, Ziming Zhang, Shanshan Xu, Lizhong DuChildren’s Hospital and First Affiliated Hospital of Zhejiang University School of Medicine. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02957-1 AbstractBackground: The interplay between intrauterine and early postnatal environments has been associated with an increased risk of cardiovascular diseases in adulthood, including pulmonary arterial hypertension

Unraveling the Mfn2-Warburg effect nexus: a therapeutic strategy to combat pulmonary arterial hypertension arising from catch-up growth after IUGR Read More »

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

Ekaterina Legchenko, Philippe Chouvarine, Fatimunnisa Qadri, Edgar Specker, Marc Nazaré, Radoslaw Wesolowski, Susann Matthes, Michael Bader, Georg HansmannHannover Medical School. Max-Delbrück-Center for Molecular Medicine. Trypto Therapeutics GmbH. German Center for Cardiovascular Research. Charité Universitätsmedizin Berlin. University of Lübeck. Friedrich-Alexander-University Erlangen-Nürnberg. Germany Journal of the Amerian College of Cardiology Basic to Translational ScienceJACC Basi Transl Sci

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression Read More »

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Christopher J. Rhodes, Adam Brownstein, Lloyd L. Liang, Laila Aryan, Min Li, Arjun Vadgama, Zeyneb Kurt, Tae-Hwi Schwantes-An, Elizabeth A. Mickler, Stefan Gräf, Mélanie Eyries, Katie A. Lutz, Michael W. Pauciulo, Richard C. Trembath, Frédéric Perros, David Montani, Nicholas W. Morrell, Florent Soubrier, Martin R.

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension Read More »

Animal models of pulmonary arterial hypertension associated with atrial septal defect

Li Wang, Ting Tang, Xiaochun Tian, Chang Peng, Shuqi WuGuizhou Children’s Hospital and Affiliated Hospital of Zunyi Medical University. China Scientific ReportsSci Rep 2024; 14: DOI: 10.1038/s41598-024-69002-5 AbstractPulmonary arterial hypertension (PAH) is a well-known complication of congenital heart disease (CHD). The lack of a satisfactory animal model for PAH associated with CHD (PAH-CHD) has limited progress

Animal models of pulmonary arterial hypertension associated with atrial septal defect Read More »

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway

Bin Liu, Dan Yi, Xiaomei Xia, Karina Ramirez, Hanqiu Zhao, Yanhong Cao, Ankit Tripathi, Ryan Dong, Anton Gao, Hongxu Ding, Shenfeng Qiu, Vladimir V. Kalinichenko,You-Yang Zhao, Michael B. Fallon, Zhiyu DaiUniversity of Arizona. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United States CirculationCirculation 2024; 150: 414-417DOI: 10.1161/CIRCULATIONAHA.123.067981 AbstractAbstract Not Available CategoryVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseAnimal Models of Pulmonary Vascular Disease and TherapyPulmonary Vascular Pathology Age Focus: No

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway Read More »

Cancer-Associated Thrombotic Microangiopathy: Literature Review and Report of Five Cases

L. Posado-Domínguez, A. J. Chamorro, E. Del Barco-Morillo, M. Martín-Galache, D. Bueno-Sacristán, E. Fonseca-Sánchez, A. Olivares-HernándezUniversity Hospital of Salamanca and University of Salamanca. Spain LifeLife 2024; 14:DOI: 10.3390/life14070865 AbstractThrombotic microangiopathy (TMA) is an anatomopathological lesion mediated by endothelial dysfunction and characterized by the creation of microthrombi in small vessels. In patients with cancer, it may be

Cancer-Associated Thrombotic Microangiopathy: Literature Review and Report of Five Cases Read More »

[Protective effects of 2-methoxyestradiol against hypoxic pulmonary hypertension in neonatal rats]

Ou Xie, Shan-Shan Li, Yang Luo, Le WangFirst Affiliated Hospital of Xinjiang Medical University.China Chinese Journal of Contemporary PediatricsZhongguo Dang Dai Er Ke Za Zhi 2024; 26: 757-764DOI: 10.7499/j.issn.1008-8830.2401078 AbstractObjectives: To investigate the protective effects of 2-methoxyestradiol (2ME) against hypoxic pulmonary hypertension (HPH) in neonatal rats.Methods: Ninety-six Wistar neonatal rats were randomly divided into a normoxia group, a

[Protective effects of 2-methoxyestradiol against hypoxic pulmonary hypertension in neonatal rats] Read More »

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation

Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu, Zhenghui Xiao, Zhou Yang, Yunbin XiaoUniversity of South China. Affiliated Children’s Hospital of Xiangya School of Medicine. Third Xiangya Hospital. Second Xiangya Hospital. Central South University. Changsha Yali High School. China Journal of Cardiovascular Translational

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation Read More »

Scroll to Top