Pulmonary Vascular Pathology

The Value of Lung Biopsy in Infants up to 3 Months With Diffuse Lung Disease in a Resource-Limited Setting

Pierre Goussard, Pawel Schubert, Lizelle van Wyk, Lynn Booysen, André Gie, Michael Urban, Jacques Janson, Savvas Andronikou, Ernst EberStellenbosch University and Tygerberg Hospital. University of the Witwatersrand. Children’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Medical University of GrazSouth Africa, United States and Austria Canadian Respiratory JournalCan Respir J 2026; DOI: 10.1155/carj/1509295 […]

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Lung biopsy strategies for childhood interstitial lung disease: Indications and techniques

Kuimiao Deng, Lin Lin, Wenhao Zhou, Junzheng PengGuangzhou Women and Children’s Medical Centre of Guangzhou Medical University. Zunyi Medical University.China Journal of International Medical ResearchJ Int Med Res 2026; DOI: 10.1177/03000605261475075 AbstractChildhood interstitial lung disease comprises a heterogeneous group of rare disorders where diffuse parenchymal involvement can cause chronic respiratory morbidity, pulmonary hypertension and death. Although advances in high-resolution computed tomography,

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Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

The NLRP3 Inflammasome Increases Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension

Emmanouil Mavrogiannis, Rebeca Weldeghebreal, Iris R. Schilthuis, Zain K. Fal, Niels J. Kloosterhuis, Mirjam H. Koster, Wim Timens, Johannes M. Douwes, Rolf M. F. Berger, Marit WesterterpBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Netherlands Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70354 AbstractPulmonary arterial hypertension (PAH) is a progressive vasculopathy leading to right-sided

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Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare

Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia Read More »

Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia

Chantal Gaudet, Kathrine L. Daniel, Sophie Holcik, Ali Hamraghani, Behzad Yeganeh, Robert P JankovChildren’s Hospital of Eastern Ontario. University of Ottawa. Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00090.2026 AbstractBronchopulmonary dysplasia (BPD) is a neonatal lung injury characterized by inflammation, and alveolar and vascular hypoplasia

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Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy

Tamer Abusido, Saleh Alshaibi, Abdullah Aldraihem, Abdulmajeed AlfadhelAbdullah Specialized Children Hospital and King Abdulaziz Medical City. King Saud Bin Abdulaziz University for Health Sciences. King Abdullah International Medical Research Center. Saudi Arabia Respiratory Medicine Case ReportsRespir Med Case Rep 2026; 62: DOI: 10.1016/j.rmcr.2026.102456 AbstractBackground: Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD-MPV) is a rare

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Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats

Guoliang Wang, Jie Liu, Peiyi Bai, Hong Jiao, Xiaohui Kong, Zhangke Guo, Gaopeng Li, Aijun LiuBeijing Children’s Hospital, Beijing Pediatric Research Institute, Capital Medical University and National Center for Children’s Health. Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences and Tongji Shanxi Hospital. General Hospital of Taiyuan Iron and

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats Read More »

Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Cristina Almagro-Pérez, Niccolò Peruzzi, Csaba Galambos, Andrew H.Song, Hans Brunnström, KingaI. Gawlik, MarcoStampanoni, Karin Tran-Lundmark, Goran LovricPaul Scherrer Institut. Institute for Biomedical Engineering. Lund University and Skåne University Hospital Lund. University of Colorado Anschutz Medical Campus School of Medicine. University of Texas MD Anderson Cancer Center. Switzerland, Sweden and United States Journal of the Royal

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KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension

Rehab Alharbi, Merve Keles, Nadia Fernandes, Hannah Maude, Adam Fellows, Richard D. Williams, Chien-Nien Chen, Nathalie Lambie, Nik Matthews, May Al-Sahaf, Sam N. Barnett, Minzhe Guo, Lan Zhao, Allan Lawrie, Jeffrey A. Whitsett, Inês Cebola, Beata Wojciak-StothardImperial College London. University of Hafr Al Batin. Hammersmith Hospital. Cincinnati Children’s Hospital Medical Center and University of Cincinnati

KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension Read More »

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