Pulmonary Vascular Pathology Archives

Macrophages Contribute to Pulmonary Hypertension Associated With Sickle Cell Disease

Christina Lisk, Francesca Cendali, Natalie Westover, Delaney Swindle, Daniel Colon Hidalgo, Caitlin Lewis, Melissa J. Lucero, Nishant K. Rana, Gemlyn George, Saini Setua, Monika Dzieciatkowska, Kathryn Hassel, Christy S. Niemeyer, Kurt Stenmark, Eva Nozik, Angelo D’Alessandro, Paul W. Buehler, David C. IrwinUniversity of Colorado Denver – Anschutz Medical Campus. Children’s Hospital Colorado. University of Maryland

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Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension

Yoshihito Morimoto, Yoshiaki Sato, Katsuhiro Kato, Hidenori Yamamoto, Kentaro Suzuki, Kiyotaka Go, Yoshie Fukasawa, Naoki Ohashi, Yoshiyuki Takahashi, Taichi KatoNagoya University Graduate School of Medicine and Nagoya University Hospital. National Cerebral and Cardiovascular Center. Japan Journal of Molecular and Cellular Cardiology PlusJ Mol Cell Cardiol Plus 2026; 18: DOI: 10.1016/j.jmccpl.2026.100867 AbstractRationale: Although plexiform lesion (PL)

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Chronic Mixed-Allergen Exposure Induces Pulmonary Arterial Remodeling and Vascular Dysfunction in Mice

Mohammad Irshad Reza, Maxwell Mathias, Venkatachalem Sathish University of Oklahoma Health Campus.United States American Journal of Physiology Lung Cullular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00238.2026 AbstractChronic asthma can be associated with secondary pulmonary vascular dysfunction, however, the detailed functional profiling of the asthmatic pulmonary artery remains understudied. In this study,

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The Value of Lung Biopsy in Infants up to 3 Months With Diffuse Lung Disease in a Resource-Limited Setting

Pierre Goussard, Pawel Schubert, Lizelle van Wyk, Lynn Booysen, André Gie, Michael Urban, Jacques Janson, Savvas Andronikou, Ernst EberStellenbosch University and Tygerberg Hospital. University of the Witwatersrand. Children’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Medical University of GrazSouth Africa, United States and Austria Canadian Respiratory JournalCan Respir J 2026; DOI: 10.1155/carj/1509295

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Lung biopsy strategies for childhood interstitial lung disease: Indications and techniques

Kuimiao Deng, Lin Lin, Wenhao Zhou, Junzheng PengGuangzhou Women and Children’s Medical Centre of Guangzhou Medical University. Zunyi Medical University.China Journal of International Medical ResearchJ Int Med Res 2026; DOI: 10.1177/03000605261475075 AbstractChildhood interstitial lung disease comprises a heterogeneous group of rare disorders where diffuse parenchymal involvement can cause chronic respiratory morbidity, pulmonary hypertension and death. Although advances in high-resolution computed tomography,

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Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

The NLRP3 Inflammasome Increases Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension

Emmanouil Mavrogiannis, Rebeca Weldeghebreal, Iris R. Schilthuis, Zain K. Fal, Niels J. Kloosterhuis, Mirjam H. Koster, Wim Timens, Johannes M. Douwes, Rolf M. F. Berger, Marit WesterterpBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Netherlands Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70354 AbstractPulmonary arterial hypertension (PAH) is a progressive vasculopathy leading to right-sided

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Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare

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Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia

Chantal Gaudet, Kathrine L. Daniel, Sophie Holcik, Ali Hamraghani, Behzad Yeganeh, Robert P JankovChildren’s Hospital of Eastern Ontario. University of Ottawa. Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00090.2026 AbstractBronchopulmonary dysplasia (BPD) is a neonatal lung injury characterized by inflammation, and alveolar and vascular hypoplasia

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Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy

Tamer Abusido, Saleh Alshaibi, Abdullah Aldraihem, Abdulmajeed AlfadhelAbdullah Specialized Children Hospital and King Abdulaziz Medical City. King Saud Bin Abdulaziz University for Health Sciences. King Abdullah International Medical Research Center. Saudi Arabia Respiratory Medicine Case ReportsRespir Med Case Rep 2026; 62: DOI: 10.1016/j.rmcr.2026.102456 AbstractBackground: Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD-MPV) is a rare

Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy Read More »