Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling

Hyunbum Kim, Yu Liu, Jiwon Kim, Yunhye Kim, Timothy Klouda, Sudeshna Fisch, Seung Han Baek, Tiffany Liu, Suzanne Dahlberg, Cheng-Jun Hu, Wen Tian, Xinguo Jiang, Kosmas Kosmas, Helen A Christou, Benjamin D. Korman, Sara O. Vargas, Joseph C. Wu, Kurt R. Stenmark, Vinicio de Jesus Perez, Mark R. Nicolls,Benjamin A. Raby, Ke Yuan European Molecular […]

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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension

Yi- Yin Tai, Qiujun Yu, Ying Tang, Wei Sun, Neil J. Kelly, Satoshi Okawa, Jingsi Zhao, Tae- Hwi Schwantes-An, Caroline Lacoux, Stephanie Torrino, Yassmin Al Aaraj, Wadih El Khoury, Vinny Negi, Mingjun Liu, Catherine G. Corey, Frances Belmonte, Sara O. Vargas, Brian Schwartz, Bal Bhat, B. Nelson Chau, Jason H. Karnes, Taijyu Satoh, Robert J.

Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension Read More »

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C. U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwarzHarper Cancer Research Institute and University of Notre Dame.United States Circulation ResearchCirc Res 2023; 133: 704-719DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension (PH) is poorly

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension

Megan M. Lowery, Nicholas S. Hill, Lu Wang, Erika B. Rosenzweig, Aparna Bhat, Serpil Erzurum, J. Emanuel Finet, Christine L. Jellis, Sunjeet Kaur, Deborah H. Kwon, Rawan Nawabit, Milena Radeva, Gerald J. Beck, Robert P. Frantz, Paul M. Hassoun, Anna Hemnes, Evelyn M. Horn, Jane A. Leopold, Franz P. Rischard, Reena Mehra, Pulmonary Vascular Disease

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Serum Metabolomic Profile in Hypoxia-Induced Pulmonary Hypertension Mice after C75 Treatment

Shun Chen, Shujia Lin, Wei Liu, Qiuping Lin, Yi Yang, Qingzhu Qiu, Yanfang Zong, Tingting Xiao, Cuilan Hou, Lijian XieShanghai Children’s Hospital and Shanghai Jiao Tong University School of Medicine. NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology. JinShan Hospital and Fudan University.China Frontiers in Bioscience Landmark EditionFront Biosci (Landmark Ed) 2023; 28:

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Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly

Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension Read More »

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis

Hai-Rong Li, Guan-Liang Chen, Xiao-Li Fang, Xing-jiu Cai, Rong-Li Xu, Dong-Dong Li, Zhi-Wei ZhangSouthern Medical University. Hainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University. Guangdong General Hospital.China American Journal of HypertensionAm J Hypertens 2023; DOI: 10.1093/ajh/hpad028 AbstractBackground: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis Read More »

Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries

Yan Bai, Guang Li, Laiming Yung, Paul B. Yu, Xingbin AiMassachusetts General Hospital and Harvard Medical School. Brigham and Women’s Hospital. Renmin Hospital and Wuhan University. United States and China American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L114-L124DOI: 10.1152/ajplung.00293.2022 AbstractIntrapulmonary arteries located in the proximal lung

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SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Min Li, Lydie Plecita-Hlavata, Evgenia Dobrinskikh, B. Alexandre McKeon, Aneta Gandjeva, Suzette Riddle, Aya Laux, Ram Raj Prasad, Sushil Kumar, Rubin M. Tuder, Hui Zhang, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado Denver – Anschutz Medical Campus. Czech Academy of Sciences. United States and Czech Republic American Journal of Respiratory Cell and Molecular BiologyAm J

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PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells

Yujing Zhao, Juan Wu, Shuai Guan, Ting Xue, Xiaolei Wei, Dawei Cao, Pengzhou Kong, Xinri ZhangThe First Hospital of Shanxi Medical University. The First People’s Hospital of Datong.China International Journal of Chronic Obstructive Pulmonary DiseaseInt J Chron Obstruct Pulmon Dis 2023; 18: 1319-1332DOI: 10.2147/COPD.S406453 AbstractPurpose: Pulmonary artery hypertension (PAH) is a common complication of chronic obstructive pulmonary

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