Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation

Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States Physiological ReportsPhysiol Rep 2022; DOI: 10.14814/phy2.15342 AbstractThe hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) respond to hypoxia with epidermal growth factor (EGF) mediated activation of the receptor tyrosine kinase, EGF […]

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Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage

Andreas Damianos, Shathiyah Kulandavela, Pingping Chen, Patrick Nwajei, Sunil Batlahally, Mayank Sharma, Silvia Alvarez-Cubela, Juan Dominguez-Bendala, Ronald Zambrano, Jian Huang, Joshua M. Hare, Augusto Schmidt, Merline Benny, Nelson Claure, Karen YoungUniversity of Miami Miller School of Medicine.United States Journal of Applied PhysiologyJ Appl Physiol 2022; 133: 1031-1041DOI: 10.1152/japplphysiol.00708.2021 AbstractAdults born preterm have an increased risk of

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High altitude simulation testing in patients with congenital diaphragmatic hernia

Ashlyn E. Whitlock, Catherine A. Sheils, Jill M. Zalieckas, Gary Visner, Mary Mullen, Mollie Studley, Lindsay Lemire, Terry L. BuchmillerBoston Children’s Hospital and Harvard Medical School.United States Journal of Pediatric SurgeryJ Pediatr Surg 2022; 57: 195-198DOI: 10.1016/j.jpedsurg.2021.10.044 AbstractAim of study: Congenital Diaphragmatic Hernia (CDH) is associated with lung hypoplasia and pulmonary hypertension. Many patients receive care in

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