Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients

Gabriel F. Diaz, Carlos E. Diaz‐Castrillon, Alicia Marquez Garcia, Rachel K. Hopper, Vinicio de J. PerezUniversidad Nacional De Colombia. University of Pittsburgh. Centro Policlínico Del Olaya and Clínica De La Mujer. Stanford University School of Medicine. Columbia and United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70017 AbstractPulmonary hypertension (PH) at high altitudes presents unique characteristics […]

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miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6

Yingjie Wang, Le Sun, Xianxian Jia, Miao Yang, Wei XuShengjing Hospital of China Medical University.China FASEB JournalFASEB J 2025; 39:DOI: 10.1096/fj.202401069RRR AbstractPulmonary hypertension of the newborn (PHN) is a common pulmonary vascular disease in newborns, affecting the prognosis of affected infants and even leading to death. Currently, there is still no specific targeted prevention and treatment

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High Altitude May Protect Against the Early Development of Irreversible Pulmonary Hypertension in Patients With Congenital Heart Disease

Inge von Alvensleben, Brian B. Graham, Gustavo A. Balanza, Carlos Brockmann, Ericka C. Pérez, Ximena Y. Vicente, Carla Arteaga, Claudia Scherer, Franz P. Freudenthal, Rubin M. Tuder, Alexandra HeathKardiozentrum. University of Colorado. University of California San Francisco. Massachusetts General Hospital and Harvard Medical School. Hospital Belga.Bolivia and United States Pulmonary CirculationPulm Circ 2025; 15:  DOI: 10.1002/pul2.70049

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A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes

Thi-Tina N. Nguyen, Caitlin V. Lewis, Daniel Colon Hidalgo, Janelle N. Posey, Mariah Jordan, Timothy E. Porfilio, Maya R. Grayck, Clyde J. Wright, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Frontiers in PhysiologyFront Physiol 2025; 16: DOI: 10.3389/fphys.2025.1513703 AbstractExtremely preterm birth predisposes infants to bronchopulmonary dysplasia and associated pulmonary hypertension (PH).

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Prolonged postnatal adaptation and enhanced prevalence of congenital heart diseases due to altitude may contribute to newborn mortality in Bolivia

Alexandra Heath, Inge von Alvensleben, Jesús Ardiles Spielvogel, Pablo Freudenthal, Johannes Trapp, Ivanna Noya, Miguel Gálvez, Fanny Mendizábal, Mariana Gonzales, Ceylan Apaza, Leibniz Sanga, Erin Mc Cann, Colleen G. JulianKardiozentrum. University of Witten. University of Munich. Hospital ‘Arco Iris’. Hospital Municipal Boliviano Holandés. University of Cincinnati. University of Colorado.Bolivia, Germany and United States Experimental PhysiologyExp

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Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α

Amanda Czerwinski, Paul Sidlowski, Emily Mooers, Yong Liu, Ru-Jeng Teng, Kirkwood Pritchard Jr., Xigang Jing, Suresh Kumar, Amy Y. Pan, Pengyuan Liu, Girija G. Konduri, Adeleye AfolayanMedical College of Wisconsin. University of Arizona College of Medicine. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0353OC AbstractHypoxia-inducible factors

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α Read More »

Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model

Akash Gupta, Nahla Zaghloul, Senthil Kumar Thulasingam, Ian Richard Robbins, Geetanjali Gupta, Jad Bader, Joe Gn Garcia, Mohamed AhmedUniversity of Arizona. University of Florida. United States Translational ResearchTransl Res 2025; DOI: 10.1016/j.trsl.2025.02.001 AbstractChAT-expressing T cells represent ∼0.01% of total circulating T lymphocytes in adult wild-type mice. However, we previously reported that systemic infusion of ChAT+ve Jurkat

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Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension in Rats

Ekaterina Legchenko, Philippe Chouvarine, Klea Hysko, Fatimunnisa Qadri, Radoslw Wesolowski, Edgar Specker, Silke Glage, Martin Meier, Katharina Schwarz, Joerg Heineke, Gerhard Pohlmann, Mehmet Ramazanoglu, Michael Bader, Georg HansmannHannover Medical School. Heidelberg University Medical Faculty Mannheim. Max-Delbrück-Center for Molecular Medicine. Leibniz-Forschungsinstitut für Molekulare Pharmakologie. Fraunhofer Institute for Toxicology and Experimental Medicine. Max Delbrück Center for Molecular

Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension in Rats Read More »

Capnodynamic determination of end-expiratory lung volume in a porcine model of hypoxic pulmonary vasoconstriction

Aron Törnwall, Mats Wallin, Magnus Hallbäck, Per-Arne Lönnqvist, Jacob KarlssonKarolinska University Hospital. Sweden Journal of Clinical Monitoring and ComputingJ Clin Monit and Comput 2024; DOI: 10.1007/s10877-024-01251-1 AbstractPurpose: The capnodynamic method, End Expiratory Lung Volume CO2 (EELV-CO2), utilizes exhaled carbon dioxide analysis to estimate End-Expiratory Lung Volume (EELV) and has been validated in both normal lungs and lung injury

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Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle

Min Li, Brittany Alexandre McKeon, Sue Gu, Ram Raj Prasad, Hui Zhang, Sushil Kumar, Suzette Riddle, David C. Irwin, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus.United States International Journal of Molecular SciencesInt J Mol Sci 2024; 25: DOI: 10.3390/ijms252111600 AbstractPulmonary hypertension (PH) significantly impairs exercise capacity and the quality of life in patients, which is

Honokiol and Nicotinamide Adenine Dinucleotide Improve Exercise Endurance in Pulmonary Hypertensive Rats Through Increasing SIRT3 Function in Skeletal Muscle Read More »

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