Potential Biomarkers Associated with Pulmonary Vascular Disease

Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension

Catherine E. Simpson, Anjira S. Ambade, Robert Harlan, Aurelie Roux, Susan Aja, David Graham, Ami A. Shah, Laura K. Hummers, Anna R. Humnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman-Rosenzweig, Gabrielle Grunig, Michaela A. Aldred, John Barnard, Suzy A. A. Comhair, W. H. Wilson Tang, Megan Griffiths, Franz Rischard, Robert P. Frantz, Serpil […]

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Identification of protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid

Sumit Bhutada, Karin Tran-Lundmark, Benjamin Kramer, Peter Conner, Ashley M. Lowry, Eugene Blackstone, Bjorn Frenckner, Carmen Mesas-Burgos, Suneel S. ApteCleveland Clinic. Wallenberg Center for Molecular Medicine and Lund University. Skane University Hospital. Karolinska Institute. United States and Sweden Scientific ResearchSci Res 2023; 13DOI: 10.1038/s41598-023-42576-2 AbstractCongenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with

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Low-affinity insulin-like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival

Guillermo Torres, Andrew C. Lancaster, Jun Yang, Megan Griffiths, Stephanie Brandal, Rachel Damico, Dhananjay Vaidya, Catherine E. Simpson, Lisa J. Martin, Michael W. Pauciulo, William C. Nichols, D. Dunbar Ivy, Eric D. Austin, Paul M. Hassoun, Allen D. EverettJohns Hopkins University. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center and University of

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Evaluation of preterm infants having bronchopulmonary dysplasia with echocardiography and serum biomarkers

O. Pamukcu, N. Narin, S. Sunkak, A. TuncayErciyes University School of Medicıne.Turkey Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123001361 AbstractBackground and objectives: Pulmonary hypertension is frequent in infants with bronchopulmonary dysplasia. Echocardiography is easy to perform, non-invasive, and recommended by guidelines even though solely it is not enough. Catheterisation is gold standard but invasive, expensive, and

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The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes

Mohamed Ahmed, Nancy G. Casanova, Nahla Zaghloul, Akash Gupta, Marisela Rodriguez, Ian R. Robbins, Carrie L. Kempf, Xiaoguang Sun, Jin H. Song, Vivian Reyes Hernon, Saad Sammani, Sara M. Camp, Alvaro Moreira, Chaur-Dong Hsu, Joe G. N. GarciaUniversity of Arizona Health Sciences. UT Health San Antonio Long School of Medicine. United States Frontiers in PhysiologyFront

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Factors leading to supranormal cardiac index in pediatric pulmonary hypertension patients treated with parenteral prostanoid therapy

Kimberley G. Miles Paul J. Critser, Patrick D. Evers, Michelle Cash, Melissa Magness, Elizabeth Geers Meredith O’Neil, Zhiqian Gao, Nicholas J. Ollberding, Russel HirschCincinnati Children’s Hospital Medical Center and Cincinnati College of Medicine. Oregon Health and Sciences University. United States Pulmonary CirculationPulm Circ 2023;DOI: 10.1002/pul2.12264 AbstractParenteral prostanoid therapy (PPT) can result in supranormal cardiac index (SCI;

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Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension

Chen-Yu Jiang, Li-Wei Wu, Yi-Wei Liu, Bei Feng, Lin-Cai Ye, Xu Huang, Yang-Yang He, Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, Yi YanShanghai Children’s Medical Center. Henan University. Shanghaitech University. China Frontiers in ImmunologyFront Immunol 2023; DOI: 10.3389/fimmu.2023.1153573 AbstractObjective: Inflammation is recognized as a contributor in the development of pulmonary arterial hypertension

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Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity

Juan Calderón-Colmenero, Felipe Massó, Héctor González Pacheco, Julio Sandoval, Carlos Guerrero, Jorge Cervantes Salazar, José A. García-Montes, Araceli Paéz, Gabriela I. Pereira-López, Carlos Zabal-Cerdeira, Juan Pablo SandovalInstituto Nacional de Cardiologia Ignacio Chavez. Mexico Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1200395 AbstractEndothelial progenitor cells and circulating endothelial cells have been proposed as useful markers of severity and

Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity Read More »

Nutritional markers accompanying acquired chylothorax in infants: a systematic review

Kevin N. Marzotto, Tuhin Choudhary, Laura A. Wright, Meghan P. Howell, Thomas R. Kimball, Frank A. Pigula, Kurt D. PiggottTulane University School of Medicine. Louisiana State University Health.United States Nutrition ReviewsNutr Rev 2023; DOI: 10.1093/nutrit/nuad005 AbstractContext: Chylothorax is a well-established acquired complication of thoracic surgery in infants. Current data suggest acquired chylothorax may affect infant growth and

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Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension

Philippe Chouvarine, Jonas Geldner, Roberto Giagnorio, Ekatrina Legchenko, Harald Bertram, Georg HansmannHannover Medical School.Germany Pediatric Critical Care MedicinePediatr Crit Care Med 2020; 21: 340-349DOI: 10.1097/PCC.0000000000002207 AbstractObjectives: We investigated whether concentrations of circulating microRNAs differ across the hypertensive right ventricle and pulmonary circulation, and correlate with hemodynamic/echocardiographic variables in patients with pulmonary arterial hypertension versus nonpulmonary arterial hypertension

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