Potential Biomarkers Associated with Pulmonary Vascular Disease

Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications

Xiaoyu Zhang, Liming Cheng, Jiahui Xie, Xuejuan Ma, Wenting Gui, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Kunming Children’s Hospital, Chinese Academy of Medical Sciences and Affiliated Cardiovascular Hospital of Kunming Medical University. China Frontiers in PhysiologyFront Physiol 2025; 14: DOI: 10.3389/fphys.2025.1673181 AbstractBackground: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling […]

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Can N-terminal pro-brain natriuretic peptide accurately diagnose chronic pulmonary hypertension among extremely low gestational age neonates: A Retrospective Cohort Study

Macarena Garcia Gozalo, Amish Jain, Dany E. Weisz, Bonny JasaniLa Paz University Hospital.  Mount Sinai Hospital. University of Toronto. Sunnybrook Health Sciences Centre. Hospital for Sick Children.Spain and Canada Journal of PerinatologyJ Perinatol 2025; DOI: 10.1038/s41372-025-02462-3 AbstractObjective: To evaluate the utility of N-terminal pro-brain natriuretic peptide (NT pro-BNP) for screening and diagnosis of chronic pulmonary hypertension (cPH)

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Gene and metabolite changes triggered by downregulation of JUNB and ZNF281 in idiopathic pulmonary arterial hypertension: potential mechanisms revealed by multi-omics study

Yanfang Zong, Wei Liu, Jiahe Tian, Cuilan Hou, Tingting Xiao, Sirui Song, Xunwei JiangShanghai Children’s Hospital School of Medicine and Shanghai Jiao Tong University.China Translational PediatricsTransl Pediatr 2025; 14: 2572-2585DOI: 10.21037/tp-2025-370 AbstractBackground: Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease causing right heart failure. Idiopathic PAH (IPAH), a type of PAH with unknown causes, has

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Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review

Sagad O.O. Mohamed, Amged Mohammed, Fatima S.K. Salih, Hozifa A.M. Elgadal, Ayman A.A. Elsamany, Mohamed S.K. Salih, Huda M.A. Mustafa, Israa Elawad, Mona G.A. Ahmedkaroum, Safaa G.A. Saeed, Rowa E.A. Ibrahim, Esraa A. Mohamedien, Aya A.H. Babiker, Esraa T. Suliman, Eman O.E. MohamedUniversity of Khartoum. Médecins Sans Frontières. University of Bahri. Ibri Regional Hospital. Harlem

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Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study

Hamdy El-Sayed, Hala Elmarsafawy, Basma Shouman, Mostafa Mansour, Amal OsmanMansoura University.Egypt Archive de PédiatrieArch Pediatr 2025; DOI: 10.1016/j.arcped.2025.08.004 AbstractBackground: Pediatric pulmonary arterial hypertension (PAH) is a potentially fatal disease. New targeted therapies based on the underlying pathogenesis are still needed.Objective: This study aims to evaluate the role of leukotriene E4, an inflammatory mediator, in developing pediatric pulmonary arterial

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International Society for Heart and Lung Transplantation (ISHLT) Consensus Statement on Risk Stratification in Pulmonary Arterial Hypertension

Sandeep Sahay 1, Scott Visovatti 2, Adriano R Tonelli 3, Nelson Villasmil Hernandez 4, Eric D Austin 5, Roberto Badagliacca 6, Rolf M F Berger 7, Athénaïs Boucly 8, Yucheng Chen 9, Colin Church 10, Marion Delcroix 11, Allen D Everett 12, Harrison W Farber 13, Charles Fauvel 14, Mardi Gomberg-Maitland 15, Megan Griffiths 16, Francois Haddad 17, Yuchi Han 18, Anna Hemnes 5, Marius M Hoeper 19, Manreet K Kanwar 20, Daniel Lachant 21, Sandhya Murthy 22, Karen M Olsson 19, Ioana Preston 23, Göran Rådegran 24, Olivier Sitbon 25, Maria G Trivieri 26, Jean-Luc Vachiery 27, Rebecca Vanderpool 2, Jason Weatherald 28, R James White 21, Helen Whitford 29, Melisa Wilson 30, Raymond L Benza  Houston Methodist Hospital. Ohio State University.

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Inflammatory Markers During Extracorporeal Membrane Oxygenation in Neonates With Congenital Diaphragmatic Hernia

Friederike M. Krechel, Judith Leyens, Eva Schoenenborn, Ramona Dolscheid-Pommerich, Bartolomeo Bo, Tamene Melaku, Christoph Berg, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University Hospital Bonn and University of Bonn. British Colombia Women’s and Children’s Hospital and University of British Colombia. University Hospital Cologne. University Medical Center Mannheim and University of Heidelberg.Germany and Canada American Society of Artificial

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Targeted Proteomic Analysis of Sickle Cell Disease Patients With Elevated Tricuspid Regurgitation Velocity

Varshini Babu, Jane A. Little, Claudia R. Morris, Roberto Machado, Simon Gibbs, Gregory A. Kato, Victor R. Gordeuk, MArk T. Gladwin, Yingze Zhang, Seyed Mehdi NouraieUniversity of Pittsburgh. University of North Carolina at Chapel Hill.  Emory University School of Medicine and Children’s Healthcare of Atlanta. Indiana University. Imperial College London. CSL Behring. University of Illinois

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Reassessment of the Current Iron Deficiency Definition in Pulmonary Hypertension

Aurelia E. Reiser, Markus Thiersch, Max Gassmann, Martina U. Muckenthaler, Thomas Geiser, Mona Lichtblau, Silvia UlrichUniversity of Zürich. University of Heidelberg. University of Berne.Switzerland and Germany Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70142 AbstractIron deficiency (ID) is prevalent in pulmonary hypertension(PH), but there is no consensus on ID definition and its possible correlation to prognostic markers.

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Enhancing Drug Development for Paediatric Pulmonary Hypertension-An Integrative Perspective

Steven H. Abman, Sylvia M. Nikkho, Rolf M. F. Berger, Maria Jesus del Cerro, Eric D. Austin, Maurice Beghetti, Dunbar Ivy, Megan Griffiths, Anne Hilgendorff, Steven H. Kawut, Usha S. Krishnan, Mary P. Mullen, Shahin Moledina, Bernard Thébaud, Norman StockbridgeUniversity of Colorado School of Medicine and Children’s Hospital Colorado. Bayer AG. Beatrix Children’s Hospital, University

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