Pediatric Pulmonary Vascular Disease

Treatment options for children with pulmonary arterial hypertension associated with congenital heart disease

Julie Wacker, Raphael Joye, Maurice BeghettiGeneva University Hospitals.Switzerland Expert Review of Respiratory MedicineExpert Rev Respir Med 2025; DOI: 10.1080/17476348.2025.2581340 AbstractIntroduction: Pulmonary hypertension associated with congenital heart disease (PAH-CHD) represents one of the leading causes of pediatric pulmonary hypertension. Within this entity, patients can be classified into distinct subgroups, each characterized by specific clinical features, pathophysiological mechanisms, and […]

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Persistent Pulmonary Hypertension of the Newborn: A Pragmatic Review of Pathophysiology, Diagnosis, and Advances in Management

Karolina Chojnacka, Yogen Singh, Sheen Gahlaut, Witold Blaz, Agata Jerzak, Tomasz SzczapaPoznan University of Medical Sciences. University of California and UC Davis Children’s Hospital. Oxford University. Saint Jadwiga the Queen Clinical Provincial Hospital and University of Rzeszow.Poland, United States and United Kingdom BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13102332 AbstractPersistent pulmonary hypertension of the newborn (PPHN) results from

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Abnormal Fetal/Neonatal Lung Development Manifested as Some Functional Heart Abnormalities During the Third Trimester of Fetal Life

Julia Murlewska, Oskar Sylwestrzak, Maciej Słodki, Iwona Strzelecka, Łukasz Sokołowski, Monika Wójtowicz-Marzec, Iwona Maroszynska, Ewa Cichos, Hanna Romanowicz, Anita J. Moon-Grady, Maria Respondek-LiberskaPolish Mother’s Memorial Hospital Research Institute. Mazovian Academy in Plock. Medical University of Lodz. Medical University of Lublin. Benioff Children’s Hospital and University of California, San Francisco.Poland and United States BiomedicinesBiomedicines 2025; 13:

Abnormal Fetal/Neonatal Lung Development Manifested as Some Functional Heart Abnormalities During the Third Trimester of Fetal Life Read More »

Novel Pulmonary Manifestations in Pediatric Late-Onset Congenital Central Hypoventilation Syndrome: A Case Series of PHOX2B-Associated Pulmonary Hypertension and Pulmonary Alveolar Hemorrhage

Yuhong Guan, Xiaohui Wen, Xiaoyan Zhang, zhifei Xu, Shunying Zhao, Haiming YangBeijing Children’s Hospital, Capital Medical University and National Center for Children’s Health.China Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71347 AbstractAnstract Not Available CategoryClass III. Pulmonary Hypertension Associated with Airway Disease, Apnea or HypoventilationSymptoms and Findings Associated with Pulmonary Vascular Disease Age Focus: Pediatric Pulmonary Vascular

Novel Pulmonary Manifestations in Pediatric Late-Onset Congenital Central Hypoventilation Syndrome: A Case Series of PHOX2B-Associated Pulmonary Hypertension and Pulmonary Alveolar Hemorrhage Read More »

Fenfluramine treatment beyond dravet and lennox-gastaut syndromes – A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs)

Amy Urbina Lopez, Robin T. Varughese, Candice Marti, Aizara Ermekbaeva, Poduri Annapurna, Kothare Sanjeev, Yash ShahTulane University School of Medicine. Cohens Children’s Hospital and Northwell Health. Boston Children’s Hospital. Our Lady of the Lake Children’s Health.United States SeizureSeizure 2025; 133: 161-166DOI: 10.1016/j.seizure.2025.09.013 AbstractIntroduction: Fenfluramine (FFA), an amphetamine derivative, was historically used as an appetite suppressant but was

Fenfluramine treatment beyond dravet and lennox-gastaut syndromes – A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs) Read More »

Two case reports of idiopathic prenatal closure of the ductus arteriosus complicated at birth by severe pulmonary hypertension successfully treated without intubation

Leonce Mwizerwa, Raphael Joye, Vladimir L. Cousin, Iliona Malaspinas, Maya Bouhabib, Hugues Lucron, Maurice Beghetti, Julie WackerGeneva University Hospitals and University of Geneva. AP-HP Paris-Saclay University and Bicêtre Hospital.Switzerland and France Translational PediatricsTrans Pediatr 2025; 14: 2374-2380DOI: 10.21037/tp-2025-264 AbstractBackground: Prenatal closure of the ductus arteriosus (DA) is an uncommon but potentially severe condition that can result in

Two case reports of idiopathic prenatal closure of the ductus arteriosus complicated at birth by severe pulmonary hypertension successfully treated without intubation Read More »

A Joint Perspective on End-of-Life Care in Pediatric Pulmonary Hypertension

Rebecca Kameny, Steve Van Wormer, Nidhy P. VargheseStanford University. Phaware Global Association. Baylor College of Medicine and Texas Children’s Hospital.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70181 AbstractAbstract Not Available CategoryOther: Commentary on End of Life Care Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication

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Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study

Yuko Walisaka, Kei Inai, Gen Harada, Seiji Asagai, Eriko ShimadaTokyo Women’s Medical University.Japan Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125110159 AbstractBackground: Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been reported, especially before

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Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia

Eric D. Austin, Mary P. Mullen, Catherine M. Avitabile, Usha S. Krishnan, Erika B. Rosenzweig, Roberta L. Keller, John P. Kinsella, Delphine Yung, Lea Steffes, Angela Bates, Eleni G. Elia, Lewis H. Romer, Sharon McGrath-Morrow, Meghan L. Bernier, Kenneth D. Mandl, J.Usha Raj, Lynn A. Sleeper, Steven H. AbmanVanderbilt University Medical Center. Boston Children’s Hospital

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Successful percutaneous closure of ventricular septal defects associated with pulmonary hypertension using different atrial septal defect Occluders: A report of two cases

José Luis Colín-Ortiz, Rogelio Zúñiga-Gordillo, Linda Fabiola Pérez-Pérez, Carlos Balcázar-Ochoa, Roberto Tepatzi-Carranco, Rosa María García-MejíaHospital of Poblano Child. Southern General Hospital of Puebla. Tlaxcala’s Children Hospital.Mexico Journal of Cardiology CasesJ Cardiol Cases 2025; 32: 171-174DOI: 10.1016/j.jccase.2025.06.010 AbstractWe present two cases of children with muscular ventricular septal defects (mVSD) and severe pulmonary hypertension. Both children successfully underwent

Successful percutaneous closure of ventricular septal defects associated with pulmonary hypertension using different atrial septal defect Occluders: A report of two cases Read More »

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