Pediatric Pulmonary Vascular Disease

Adenosine reverses life-threatening persistent pulmonary hypertension of the neonate refractory to triple vasodilator therapy

Lucie Genet, Daniele De Luca“A.Béclère” Medical Center and Paris Saclay University Hospitals.France Cardiology in the YoungCardiol Young 2022; 32: 996-997DOI: 10.1017/S1047951121004157 AbstractPersistent pulmonary hypertension of the neonate can cause acute and life-threatening hypoxia, but preterm neonates are not suitable candidate to extra-corporeal life support. We report the unique case of an extremely preterm neonates with life-threatening […]

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Pulmonary lymphangiectasia in myotubular myopathy: a novel unrecognized association?

Gabriela de Carvalho Nunes, Karl Grenier, Chelsea Maedler Kron, Thomas Kitzler, Janine El Helou, David S. Rosenblatt, Francois OlivierMcGill University Health Centre. Jewish General Hospital.Canada Neuromuscular DisordersNeuromuscul Disord 2022; 32: 512-515DOI: 10.1016/j.nmd.2022.04.010 AbstractChylothorax has been reported in rare cases of X-linked myotubular myopathy, but the pathophysiology of this association is not fully understood. We report a

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Case report: Pulmonary hypertensive crisis leading to cardiac arrest during endoscopic evaluation in a 6-year-old boy with autism, severe malnutrition, and undiagnosed scurvy

Laura A. Quinn, Stephanie P. Gilley, Allison D. Ta, Benjamin S. Frank, Carolyn B. Foley, Jaime M. MooreUniversity of Colorado School of Medicine.United States Frontiers in PediatricsFront Pediatr 2022; DOI: 10.3389/fped.2022.1008507 AbstractPediatric gastroenterologists are often responsible for the evaluation of malnutrition in the setting of selective eating. Endoscopic evaluation for conditions including eosinophilic esophagitis and celiac

Case report: Pulmonary hypertensive crisis leading to cardiac arrest during endoscopic evaluation in a 6-year-old boy with autism, severe malnutrition, and undiagnosed scurvy Read More »

Hidden cardiovascular morbidity in children and young adults born with congenital diaphragmatic hernia: A population-based study

Katarina Övermo Tydén, Felicia Nordenstam, Björn Frenckner, Carmen Mesas BurgosKarolinska University Hospital. Sweden Journal of Pediatric SurgeryJ Pediatr Surg 2022; 57: 510-515DOI: 10.1016/j.jpedsurg.2022.03.028 AbstractIntroduction: Congenital diaphragmatic (CDH) hernia is a rare congenital malformation with considerable mortality and morbidity in the neonatal period. The majority of the children today survive but little is known about long term cardiovascular

Hidden cardiovascular morbidity in children and young adults born with congenital diaphragmatic hernia: A population-based study Read More »

Indications and outcome after lung transplantation in children under 12 years of age: A 16-year single center experience

Paval Iablonskii, Julia Carlens, Carsten Mueller, Khalil Aburahma, Adelheid Niehaus, Dietmar Boethig, Maximilian Boethig, Katharina Floethmann, Wiebke Sommer, Joerg Optenhoefel, Igor Tudorache, Mark Greer, Harald Koeditz, Thomas Jack, Georg Hansmann, Christian Kuehn, Alexander Horke, Gesine Hansen, Axel Haverich, Gregor Warnecke, Murat Avsar, Jawad Salman, Dmitry Bobylev, Fabio Ius, Nicolaus SchwerkHannover Medical School. Saint Petersburg State

Indications and outcome after lung transplantation in children under 12 years of age: A 16-year single center experience Read More »

Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model

Devashis Mukherjee, Ujala Rana, Alison J. Kriegel, Pengyuan Liu, Teresa Michalkiewicz, Girija Ganesh KonduriRainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Medical College of Wisconsin and Children’s Wisconsin.United States Pediatric ResearchPediatr Res 2022; 93: 551-558DOI: 10.1038/s41390-022-02151-3 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) occurs when pulmonary vascular resistance (PVR) fails to

Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model Read More »

Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant

Stephanie M. Tsoi, Kirk Jones, Elizabeth Colglazier, Claire Parker, Hythem Nawaytou, David Teitel, Jeffrey R. Fineman, Roberta L. KellerUniversity of California San Francisco.United States Pulmonary CirculationPul Circ 2022; 12: DOI: 10.1002/pul2.12108 AbstractWe present a case of a late preterm infant placed on extracorporeal life support in the first day of life for persistent pulmonary hypertension of

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Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH)

Ivonne Wieland, Franziska Diekmann, Julia Carlens, Laura Hinze, Katharina Lambeck, Thomas Jack, Georg HansmannHannover Medical School.Germany Frontiers in PediatricsFront Pediat 2022; 10: DOI: 10.3389/fped.2022.1012738 AbstractBackground and objectives: Emerging evidence suggests that increased degradation of von Willebrand factor and decrease in high molecular weight multimers occurs in patients with pulmonary hypertension (PH). However, the link between acquired von

Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH) Read More »

DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines

Avante D. Milton, Hanadi Almazrouea, Yi Jina, Gloria Zenderb, Jennifer K. TrittmannaAbigail Wexner Research Institute at Nationwide Children’s Hospital. Ohio State University College of Medicine. United States Journal of Neonatal and Perinatal MedicineJ Neonatal Perinatal Med 2022; 15: 113-121DOI: 10.3233/NPM-210710 AbstractBackground: Bronchopulmonary dysplasia (BPD) is chronic lung disease of prematurity and pulmonary hypertension (PH) is a major

DDAH1 SNP rs480414 that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia results in lower nitric oxide production in neonatal cord blood-derived lymphoblastoid cell lines Read More »

Effects of inhaled nitric oxide (iNO) in pulmonary hypertension secondary to arteriovenous malformations: a retrospective cohort study from the European iNO registry

Aravanan Anbu Chakkarapani, Samir Gupta, Asma Jamil, Santosh Kumar Yadav, Nim Subhedar, Helmut D. HummlerSidra Medicine. Weill Cornell Medicine-Qatar. Durham University. Johns Hopkins University School of Medicine. Liverpool Women’s Hospital. University of Tuebingen.Qatar, United Kingdom, United States and Germany European Journal of PediatricsEur J Pediatr 2022; 181: 3915-3922DOI: 10.1007/s00431-022-04602-9 AbstractThis study aims to assess the effects of inhaled nitric oxide (iNO) on oxygenation in the

Effects of inhaled nitric oxide (iNO) in pulmonary hypertension secondary to arteriovenous malformations: a retrospective cohort study from the European iNO registry Read More »

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