Pediatric Pulmonary Vascular Disease

Advances in the Management of Persistent Pulmonary Hypertension of the Newborn

Emily Mooers, Satyan Lakshiminrusimha, G. Ganesh KonduriMedical College of Wisconsin and Children’s Wisconsin. University of California and UC Davis Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 297-316DOI: 10.1016/j.clp.2026.02.003 AbstractThis article details an integrated approach to optimize management strategies for hypoxemic respiratory failure and hemodynamic instability in persistent pulmonary hypertension of the newborn (PPHN). Even […]

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Respiratory Management for the Infant with Congenital Diaphragmatic Hernia

Michelle J. Yang, Matthew Douglass, Ryan J. Carpenter, Bradley A. YoderUniversity of Utah School of Medicine and Primary Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 277-295DOI: 10.1016/j.clp.2026.02.002 AbstractCongenital diaphragmatic hernia (CDH) is a complex neonatal condition characterized by pulmonary hypoplasia and pulmonary hypertension, requiring specialized ventilatory management from birth through postoperative care. This article

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Association between hepatic vein Doppler and echocardiographic diastolic indices with invasively measured right ventricular filling pressures in pediatric pulmonary arterial hypertension

Tessa Palmeri, Wei Hui, Charles T. Simpkin, Andreea Dragulescu, Luc Mertens, Dunbar Ivy, Dale Burkett, Mark FriedbergHospital for Sick Children. University of Colorado Medical Campus.Canada and United States International Journal of CardiologyInt J Cardiol 2026; DOI: 10.1016/j.ijcard.2026.134619 AbstractBackground: Increased right ventricular filling pressures (RVFP) are associated with increased mortality risk in children with pulmonary arterial hypertension (PAH).

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Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension

John D. Dauz, Bahram Mirani, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergHospital for Sick Children and University of Toronto. Ted Rogers Centre for Heart Research. Canada American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2026; DOI: 10.1152/ajpheart.00459.2026 AbstractMain pulmonary artery (MPA) stiffening increases right ventricular (RV)

Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension Read More »

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia

Amed Soliz, Jorge SolizFlorida International University and Memorial Regional Hospital. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) and Université Laval. Altitude Baby Association. United States and Canada Respiratory Physiology and NeurobiologyRespir Physiol Neurobiol 2026;DOI: 10.1016/j.resp.2026.104609 AbstractHigh altitude exposes the human fetus and newborn to chronic hypobaric hypoxia, markedly reducing oxygen availability during critical

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia Read More »

A Biomimetic Miniaturized In Vitro Model to Target Early Markers of Neonatal Pulmonary Vascular Injury

Motaharehsadat Heydarian, Ali Doryab, Juan Henao, Benjamin Schubert, Otmar Schmid, Anne HilgendorffHelmholtz Zentrum München and German Lung Research Center. University of Cambridge. University Hospital Ludwig-Maximilian University. Carl von Ossietzky University.Germany and United Kingdom American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00002.2026 AbstractPulmonary vascular disease (PVD) is

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Trametinib Therapy for Hypertrophic Cardiomyopathy and Pulmonary Hypertension in a Child With RAF1-Related Noonan Syndrome (p.Ser257Leu): A Case Report

C. Noah Nilsson, Othman A. Aljohani, Michael A. Smith, Rachelle Durand, Inger Norlyk Sheyanth, Hythem Nawaytou, Elliot Stieglitz, Russel Valle, Sanjeev A. DatarUniversity of California San Francisco. Copenhagen University Hospital. United States and Denmark Clinical Case ReportsClin Case Rep 2026; 14:DOI: 10.1002/ccr3.72831 AbstractThis case describes a female infant with RAF1-related Noonan syndrome who developed severe hypertrophic obstructive

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Process Analysis of Neonatal and Pediatric Respiratory Extracorporeal Membrane Oxygenation Referrals: An 8-Year Experience at a High-Volume Center

Anna C. Dermatidis, Tom W. Bayer, Verena Varnholt, Svetlana Hetjens, Felix Dittgen, Alba Perez-Ortiz, Thomas SchaibleUniversity Children’s Hospital Mannheim, Heidelberg University Hospital and University of Heidelberg.Germany Critical care ExplorationsCrit Care Explor 2026; 8: DOI: 10.1097/CCE.0000000000001432 AbstractObjectives: To evaluate neonatal and pediatric extracorporeal membrane oxygenation (ECMO) referrals and transfers to a high-volume center and optimize the process of

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Reversible Pulmonary Arterial Hypertension Due to Fenfluramine in a Young Child: A Case Report

Uzoma Ndukwe, Adrianne Parkey, Debopam Samanta, Abdelrahman Masri, Erin WillisUniversity of Arkansas for Medical Sciences.United States CureusCureus 2026; 18: DOI: 10.7759/cureus.108354 AbstractFenfluramine is approved for Dravet syndrome and Lennox-Gastaut syndrome (LGS) in children under two years of age and is increasingly used off-label for developmental and epileptic encephalopathies (DEEs). Due to the risk of pulmonary arterial

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Anomalous origin of the right pulmonary artery from the ascending aorta: a case report and review of the literature

Alwaleed Al-Dairy, Ali Deeb, Zakaria Aldammad, Ahmad Al-BitarDamascus University. Syrian Arab Republic (Syria) International Journal of Surgery Case ReportsInt J Surg Case Rep 2026; 138: 2278-2282DOI: 10.1097/RC9.0000000000000526 AbstractIntroduction: Anomalous aortic origin of a pulmonary artery (AORPA), or hemitruncus arteriosus, is a rare congenital anomaly in which one pulmonary artery arises directly from the ascending aorta. Without timely

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