Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease

Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function

Kenzo Ichimura, Adam Gross, Roy O. Mathew, Loay Salman, Sushma Reddy, Edda Spiekerkoetter, Mandeep S. SidhuStanford University. Albany Medical College. Loma Linda VA Health Care System. United States Cardiovascular Drugs and TherapyCardiovasc Drups Ther 2024; DOI: 10.1007/s10557-024-07588-8 AbstractCardiorenal syndrome (CRS) due to right ventricular (RV) failure is a disease entity emerging as a key indicator of […]

Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function Read More »

Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension

Li Gao, John Skinner, Tanmay Nath, Qing Lin, Megan Griffiths, Rachel L. Damico, Michael W. Pauciulo, William Nichols, Paul M. Hassoun, Allen Everett, Roger A. JohnsJohns Hopkins University School of Medicine. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center and University of Cincinnati. United States Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02861-8 AbstractBackground: Abnormal

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The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives

Yunjia Song, Shuo Cao, Xutao Sun, Guozhen ChenHeilongjiang University of Chinese Medicine. The Affiliated Yantai Yuhuangding Hospital.China Mammalian GenomeMamm Genome 2024; DOI: 10.1007/s00335-024-10043-6 AbstractHydrogen sulfide (H2S) is recognized as the third gasotransmitter, after nitric oxide (NO) and carbon monoxide (CO). It is known for its cardioprotective properties, including the relaxation of blood vessels, promotion of angiogenesis,

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Phenotypic characterisation of SMAD4 variant carriers

Claire Caillot, Jean-Christophe Saurin, Valérie Hervieu, Marie Faoucher, Julie Reversat, Evelyne Decullier, Gilles Poncet, Sabine Bailly, Sophie Giraud, Sophie Dupuis-GirodFemme-Mère-Enfants Hospital and Hospices Civils de Lyon. Hôpital E. Herriot. Université Claude Bernard Lyon 1. France Journal of Medical GeneticsJ Med Genet 2024; DOI: 10.1136/jmg-2023-109632 AbstractBackground: Both hereditary haemorrhagic telangiectasia (HHT) and juvenile polyposis syndrome (JPS) are known

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Systemic sclerosis sine scleroderma in children is more aggressive than in adults

Francesca Tirelli, Elisabetta Zanatta, Beatrice Moccaldi, Marco Binda, Giorgia Martini, Chiara Giraudo, Fabio Vittadello, Alessandra Meneghel, Francesco ZulianUniversity of Padova. Italy RheumatologyRheumatology 2024; DOI: 10.1093/rheumatology/keae304 AbstractObjectives: To compare the clinical and laboratory features of pediatric systemic sclerosis sine scleroderma (ssJSSc) with adult-onset ssSSc.Methods: Demographic, clinical and laboratory data of ssJSSc, retrospectively retrieved from our hospital medical records, case

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NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea

Xiaoting Yangzhong, Shu Hua, Yiqiong Wen, Xiaoqing Bi, Min Li, Yuanyuan Zheng, Shibo SunFirst Affiliated Hospital, Kunming Medical University.China Current Molecular MedicineCurr Mol Med 2024; DOI: 10.2174/0115665240294605240426123650 AbstractObstructive sleep apnea [OSA] is widespread in the population and affects as many as one billion people worldwide. OSA is associated with dysfunction of the brain system that controls

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Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies

Tsampika-Vasileia Kalamara, Konstantino Dodos, Efthymia VlachakiHippokration General Hospital and Aristotle University of Thessaloniki.Greece Frontiers in MedicineFront Med 2023; 10: DOI: 10.3389/fmed.2023.1259785 AbstractIntroduction: Thromboembolism (TE) and pulmonary hypertension (PH) constitute frequently occurring complications in patients with transfusion-dependent thalassemia and have been associated with splenectomy in different studies. Nevertheless, the size of the possible association varies greatly in literature. Herein,

Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies Read More »

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Mikala C. Mueller, Yanmei Du, Lori A. Walker, Chelsea M. MaginUniversity of Colorado, Anschutz Medical Campus.United States Matrix Biology PlusMatrix Biol Plus 2024; DOI: 10.1016/j.mbplus.2024.100145 AbstractRespiratory diseases like pulmonary arterial hypertension (PAH) frequently exhibit sexual dimorphism. Female PAH patients are more susceptible to the disease but have increased survival rates. This phenomenon is known as the

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Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence

Stefan Muenster, Iratxe Zarragoikoetxea, Andrea Moscatelli, Joan Balcells, Philippe Gaudard, Philippe Pouard, Nandor Marczin, Stefan P. JanssensUniversity Hospital Bonn. Hospital Universitari I Politècnic Fe. IRCCS Istituto Giannina Gaslini. Universitari Vall d’Hebron. University of Montpellier. Assistance Publique-Hopitaux de Paris and Hopital Necker-Enfants Malades. Imperial College. University Hospital Leuven.Germany, Spain, Italy, France, United Kingdom and Belgium Frontiers

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Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders

Haoran Shen, Rui Zheng, Mulong Du, David C. ChristianiNanjing Medical University. Harvard T.H. Chan School of Public Health. Massachusetts General Hospital.China and United States ThoraxThorax 2024; DOI: 10.1136/thorax-2023-221302 AbstractBackground: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the

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