Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease

A germline chimeric KANK1-DMRT1 transcript derived from a complex structural variant is associated with a congenital heart defect segregating across five generations

Silvia Souza da Costa, Veniaminn Fishman, Mara Pinheiro, Andre Rodrigueiro, Maria Teresa Sanseverino, Paulo Zielinsky, Claudia M. B. Carvalho, Carla Rosenberg, Ana Cristina Victorino KrepischiUniversity of São Paulo. Siberian Branch of the Russian Academy of Sciences. Uniscience do Brasil. Hospital de Clínicas de Porto Alegre. Pontifícia Universidade Catolica do Rio Grande Do Sul. Federal University […]

A germline chimeric KANK1-DMRT1 transcript derived from a complex structural variant is associated with a congenital heart defect segregating across five generations Read More »

Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension

Anjira S. Ambade, Mario Naranjo, Tijana Tuhy, Rose Yu, Mery Marimoutou, Allen D. Everett, Larissa A. Shimoda, Stefean L. Zimmerman, Ilton M. Cubero Salazar, Catherine E. Simpson, Ryan J. Tedford, Steven Hsu, Paul M. Hassoun, Rachel L. DamicoJohns Hopkins University. Temple University. Johns Hopkins Community Physicians. Institute for In Vitro Sciences Inc. Medical University of

Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension Read More »

Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function

Kenzo Ichimura, Adam Gross, Roy O. Mathew, Loay Salman, Sushma Reddy, Edda Spiekerkoetter, Mandeep S. SidhuStanford University. Albany Medical College. Loma Linda VA Health Care System. United States Cardiovascular Drugs and TherapyCardiovasc Drugs Ther 2024; DOI: 10.1007/s10557-024-07588-8 AbstractCardiorenal syndrome (CRS) due to right ventricular (RV) failure is a disease entity emerging as a key indicator of

Cardiorenal Syndrome in Right Heart Failure Due to Pulmonary Arterial Hypertension-The Right Ventricle as a Therapeutic Target to Improve Renal Function Read More »

Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension

Li Gao, John Skinner, Tanmay Nath, Qing Lin, Megan Griffiths, Rachel L. Damico, Michael W. Pauciulo, William Nichols, Paul M. Hassoun, Allen Everett, Roger A. JohnsJohns Hopkins University School of Medicine. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center and University of Cincinnati. United States Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02861-8 AbstractBackground: Abnormal

Resistin predicts disease severity and survival in patients with pulmonary arterial hypertension Read More »

The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives

Yunjia Song, Shuo Cao, Xutao Sun, Guozhen ChenHeilongjiang University of Chinese Medicine. The Affiliated Yantai Yuhuangding Hospital.China Mammalian GenomeMamm Genome 2024; DOI: 10.1007/s00335-024-10043-6 AbstractHydrogen sulfide (H2S) is recognized as the third gasotransmitter, after nitric oxide (NO) and carbon monoxide (CO). It is known for its cardioprotective properties, including the relaxation of blood vessels, promotion of angiogenesis,

The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives Read More »

Phenotypic characterisation of SMAD4 variant carriers

Claire Caillot, Jean-Christophe Saurin, Valérie Hervieu, Marie Faoucher, Julie Reversat, Evelyne Decullier, Gilles Poncet, Sabine Bailly, Sophie Giraud, Sophie Dupuis-GirodFemme-Mère-Enfants Hospital and Hospices Civils de Lyon. Hôpital E. Herriot. Université Claude Bernard Lyon 1. France Journal of Medical GeneticsJ Med Genet 2024; DOI: 10.1136/jmg-2023-109632 AbstractBackground: Both hereditary haemorrhagic telangiectasia (HHT) and juvenile polyposis syndrome (JPS) are known

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Systemic sclerosis sine scleroderma in children is more aggressive than in adults

Francesca Tirelli, Elisabetta Zanatta, Beatrice Moccaldi, Marco Binda, Giorgia Martini, Chiara Giraudo, Fabio Vittadello, Alessandra Meneghel, Francesco ZulianUniversity of Padova. Italy RheumatologyRheumatology 2024; DOI: 10.1093/rheumatology/keae304 AbstractObjectives: To compare the clinical and laboratory features of pediatric systemic sclerosis sine scleroderma (ssJSSc) with adult-onset ssSSc.Methods: Demographic, clinical and laboratory data of ssJSSc, retrospectively retrieved from our hospital medical records, case

Systemic sclerosis sine scleroderma in children is more aggressive than in adults Read More »

NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea

Xiaoting Yangzhong, Shu Hua, Yiqiong Wen, Xiaoqing Bi, Min Li, Yuanyuan Zheng, Shibo SunFirst Affiliated Hospital, Kunming Medical University.China Current Molecular MedicineCurr Mol Med 2024; DOI: 10.2174/0115665240294605240426123650 AbstractObstructive sleep apnea [OSA] is widespread in the population and affects as many as one billion people worldwide. OSA is associated with dysfunction of the brain system that controls

NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea Read More »

Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies

Tsampika-Vasileia Kalamara, Konstantino Dodos, Efthymia VlachakiHippokration General Hospital and Aristotle University of Thessaloniki.Greece Frontiers in MedicineFront Med 2023; 10: DOI: 10.3389/fmed.2023.1259785 AbstractIntroduction: Thromboembolism (TE) and pulmonary hypertension (PH) constitute frequently occurring complications in patients with transfusion-dependent thalassemia and have been associated with splenectomy in different studies. Nevertheless, the size of the possible association varies greatly in literature. Herein,

Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies Read More »

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Mikala C. Mueller, Yanmei Du, Lori A. Walker, Chelsea M. MaginUniversity of Colorado, Anschutz Medical Campus.United States Matrix Biology PlusMatrix Biol Plus 2024; DOI: 10.1016/j.mbplus.2024.100145 AbstractRespiratory diseases like pulmonary arterial hypertension (PAH) frequently exhibit sexual dimorphism. Female PAH patients are more susceptible to the disease but have increased survival rates. This phenomenon is known as the

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation Read More »

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