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Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension

Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. GrahamUniversity of California, San Francisco and Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. United States Frontiers in ImmunologyFront Immunol 2024; DOI: 10.3389/fimmu.2024.1372957 AbstractBackground: Schistosomiasis […]

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3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension

Kenzo Ichimura, Mario Boehm, Adam M. Andruska, Fan Zhang, Katharina Schimmel, Spencer Bonham, Angela Kabiri, Vitaly O. Kheyfets, Shoko Ichimura, Sushma Reddy, Yuqiang Mao, Tianyi Zhang, Gordon Wang, Everton J. Santana, Xuefei Tian, Ilham Essafri, Ryan Vinh, Wen Tian, Mark R. Nicolls, Shin Yajima, Yasuhiro Shudo, John W. McArthur, Y. Joseph Woo, Ross J. Metzger,

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Effect of Estrogen Receptor Alpha on Cardiopulmonary Adaptation to Chronic Developmental Hypoxia in a Rat Model

Nicholas T. Severyn, Patricia Esparza, Huanling Gao, Elizabeth A. Mickler, Marjorie E. Albrecht, Amanda Fisher, Bakhtiyor Yakubov, Todd G. Cook, James E. Slaven, Avram D. Walts, Robert S. Tepper, Tim LahmUniversity of Kentucky. Indiana University – Purdue University Indianapolis. University of Colorado. National Jewish Health.United States American Journal of Physiology Lung Cellular and Respiratory PhysiologyAm

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Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University. United

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins Read More »

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Haiyang Tang, Akash Gupta, Seth A. Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R. Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A. Warfel, Louise Hecker, Sumegha Mitra, Anna W. Coleman, Katie A. Lutz, Michael W. Pauciulo, Yen-Chun Lai, Ali Javaheri,

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Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. StenmarkUniversity of Colorado School of Medicine. University of California San Francisco. Zuckerberg San Francisco General Hospital.United States Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1372959 AbstractIntroduction: Hypoxia

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension Read More »

Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells

Yi-Ching Liu, Yu-Hsin Tseng, Yu-Hsin Kuan, Lin-Yen Wang, Shang-En Huang, Siao-Ping Tsai, Iwu-Lai Yeh, Jong-Hau HsuKaohsiung Medical University Hospital and Kaohsiung Medical University. E-Da Hospital and I-Shou University. National Sun Yat-sen University. Chia Nan University of Pharmacy and Science. Taiwan Kaohsiung Journal of Medical ScienceKaohsiung J Med Sci 2024; DOI: 10.1002/kjm2.12835 AbstractPulmonary vascular remodeling is a

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The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension

Michael G. Katz, Yoav Hadas, Nataly Shtraizent, Shana Ravvin, Jeko M. Madjarov, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Wake Forest School of Medicine. United States Methods in Molecular BiologyMethods Mol Biol 2024; 2803: 173-185DOI: 10.1007/978-1-0716-3846-0_13 AbstractPulmonary hypertension (PH) is a chronic and progressive disorder characterized by elevated mean pulmonary arterial pressure, pulmonary vascular remodeling,

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension Read More »

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

Xuran Chu, Vahid Kheirollahi, Arun Lingampally, Prakash Chelladurai, Chanil Valasarajan, Ana Ivonne Vasquez-Armendariz, Stefan Hadzic, Ali Khadim, Oleg Pak, Stefano Rivetti, Jochen Wilhelm, Marek Bartkuhn, Slaven Crnkovic, Alena Moiseenko, Mohika Heiner, Simone Kraut, Leila Sotoodeh, Janine Koepke, Guilherme Valente, Clemens Ruppert, Thomas Braun, Christos SamakovlisIoannis Alexopoulos, MAria Looso, Cho-Mong Chao, Susanne Herold, Werner Seeger, Grazyna

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