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Observations on Resistance to the Flow of Blood to and from the Lungs

Richmond L. Moore, Carl A. L. BingerHospital of The Rockefeller Institute for Medical ResearchUnited States Journal of Experimental MedicineJ Exp Med 1927; 45: 655-671DOI: 10.1084/jem.45.4.655 Abstract1. Embolism of pulmonary arterioles and capillaries produced by the intravenous injection of starch grains results in a dilatation of the pulmonary artery and the right chambers of the heart. This […]

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Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly

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Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis

Hai-Rong Li, Guan-Liang Chen, Xiao-Li Fang, Xing-jiu Cai, Rong-Li Xu, Dong-Dong Li, Zhi-Wei ZhangSouthern Medical University. Hainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University. Guangdong General Hospital.China American Journal of HypertensionAm J Hypertens 2023; DOI: 10.1093/ajh/hpad028 AbstractBackground: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis Read More »

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C.U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwartzHarper Cancer Research Institute. University of Notre Dame. Indiana University School of Medicine. United States Circulation ResearchCirc Res 2023; DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology

Chien-Nien Chen, Nabil Hajji, Fu-Chiang Yeh, Sunniyat Rahman, Souad Ali, John Wharton, Nicoleta Baxan, Lin Zhao, Chong-Yang Xie, Yi-Guan Chen, Maria G. Frid, Prakash Chelladurai, Soni Savai Pullamsetti, Kurt R. Stenmark, Martin R. Wilkins, Lan ZhaoImperial College London. Tri-Service General Hospital. University of Colorado. University Giessen Lung Centre. Max Planck Institute for Heart and Lung

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology Read More »

The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices

William R. Studley, Emma Lamanna, Katherine A. Martin, Claudia A. Nold-Perry, Simon G. Royce, Owen L. Woodman, Rebecca H. Ritchie, Cheng Xue Qin, Jane E. BourkeMonash University. Hudson Institute of Medical Research. Baker Heart and Diabetes Institute.Australia British Journal of PharmacologyBr J Pharmacol 2023; DOI: 10.1111/bph.16231 AbstractBackground and purpose: Pulmonary arterial hypertension (PAH), a rare but fatal

The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices Read More »

A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics

Jason M. Szafron, Weiguang Yang, Jeffrey A. Feinstein, Marlene Rabinovitch, Alison L. MarsdenStanford University.United States Biomechanics and Modeling in MechanobiologyBiomech Model Mechanobiol 2023; DOI: 10.1007/s10237-023-01744-z AbstractHemodynamic loading is known to contribute to the development and progression of pulmonary arterial hypertension (PAH). This loading drives changes in mechanobiological stimuli that affect cellular phenotypes and lead to pulmonary

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Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph KnosallaDeutsches Herzzentrum der Charité. Charité-Universitätsmedizin Berlin. Freie Universität Berlin and Humboldt-Universität zu

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease Read More »

Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries

Yan Bai, Guang Li, Laiming Yung, Paul B. Yu, Xingbin AiMassachusetts General Hospital and Harvard Medical School. Brigham and Women’s Hospital. Renmin Hospital and Wuhan University. United States and China American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L114-L124DOI: 10.1152/ajplung.00293.2022 AbstractIntrapulmonary arteries located in the proximal lung

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SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Min Li, Lydie Plecita-Hlavata, Evgenia Dobrinskikh, B. Alexandre McKeon, Aneta Gandjeva, Suzette Riddle, Aya Laux, Ram Raj Prasad, Sushil Kumar, Rubin M. Tuder, Hui Zhang, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado Denver – Anschutz Medical Campus. Czech Academy of Sciences. United States and Czech Republic American Journal of Respiratory Cell and Molecular BiologyAm J

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