No Age-Related Focus

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

Manivannan Yegambaram, Xutong Sun, Alejandro Garcia Flores, Qing Lu, Jamie Soto, Jaime Richards, Saurabh Aggarwal, Ting Wang, Haiwei Gu, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of California San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2023; 24:DOI: 10.3390/ijms242417533 AbstractThe disruption of mitochondrial dynamics has been identified in cardiovascular diseases, including […]

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells Read More »

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension

Yi‑Chia Wu, Wei‑Ting Wang, Ming‑Chun Yang, Yu‑Tsun Su, Jwu‑Lai Yeh, Jong‑Hau Hsu, Jiunn‑Ren WuKaohsiung Medical University Hospital and Kaohsiung Medical University. Kaohsiung Municipal Ta-Tung Hospital. E-Da Hospital and I-Shou University.Taiwan Biological ResearchBiol Res 2023; DOI: 10.1186/s40659-023-00480-z AbstractBackground: Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along

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Inhalable Nitric Oxide Delivery Systems for Pulmonary Arterial Hypertension Treatment

Yoogyeong Oh, Kyungtae Park, Sungwon Jung, Moonhyun Choi, Taihyun Kim, Yoojin Kim, Yoojin Lee, Jae Young Choi, Yang-Hee Kim, Se Yong Jung, Jinkee HongYonsei University College of Medicine. University of Southampton.Republic of Korea and United Kingdom SmallSmall 2023; DOI: 10.1002/smll.202308936 AbstractPulmonary arterial hypertension (PAH) is a severe medical condition characterized by elevated blood pressure in the

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Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C. U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwarzHarper Cancer Research Institute and University of Notre Dame.United States Circulation ResearchCirc Res 2023; 133: 704-719DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension (PH) is poorly

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Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao1, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene RabinovitchLucile Packard Children’s Hospital and Stanford University School of Medicine. University Medical Center

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Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III

Manivannan Yegambaram, Xutong Sun, Qing Lu, Yan Jin, Wojciech Ornatowski, Jamie Soto, Saurabh Aggarwal, Ting Wang, Kim Tieu, Haiwei Gu, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of Arizona. University of California San Francisco.United States Free Radical Biology and MedicineFree Radic Biol Med 2023; DOI: 10.1016/j.freeradbiomed.2023.11.008 AbstractObjective: Pulmonary hypertension (PH) is a progressive disease with

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The pulmonary veins

Albert L. HymanTulane University School of Medicine.United States Annual Review of MedicineAnnu Rev Med 1966; 17: 431-446DOI: 10.1146/annurev.me.17.020166.002243 AbstractAbstract Not Available CategorySegmental Pulmonary Venous Disease. Without a Focus on Pulmonary HypertensionReview Articles Concerning Pulmonary Vascular Disease Age Focus: No Age-Related Focus Fresh or Filed Publication: Filed (PHiled). Greater than 1-2 years since publication Article Access Free

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Active response of pulmonary veins to distention of a single pulmonary vein in intact dogs

Albert L. Hyman, G. SanchezTulane University School of Medicine.United States Journal of Laboratory and Clinical MedicineJ Lab Clin Med 1969; 73: 476-485DOI: Not Available AbstractAbstract Not Available CategorySegmental Pulmonary Venous Disease. Without a Focus on Pulmonary HypertensionAnimal Models of Pulmonary Vascular Disease and Therapy Age Focus: No Age-Related Focus Fresh or Filed Publication: Filed (PHiled).

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CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension

Abraham Rothman, Humberto Restrepo, William N. Evans, Valeri Sarukhanov, David MannUniversity of Nevada Las Vegas. Vascular BioSciences.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-e230404-2022-19 AbstractBackground: Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.Objectives: This study aimed to

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Ambulatory Seven-Day Mechanical Circulatory Support in Sheep Model of Pulmonary Hypertension and Right Heart Failure

Rei Ukita, Yatrik J. Patel, W. Kelly Wu, Sean A. Francois, Michael Cortelli Jr, Carl A. Johnson Jr, Nancy Cardwell, Jennifer R. Talackine, John W. Stokes, William Grogan, Meredith Mentz, Kaitlyn M. Tracy, Timothy R. Harris, William Tucker, Elizabeth Simonds, Caitlin T. Demarest, Keith E. Cook, David J. Skoog, Erika B. Rosenzweig, Matthew BacchettaVanderbilt University

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