Medical Therapy. Adverse Effects or Lack of Adverse Effects

Safety and Tolerability of Continuous Inhaled Iloprost Therapy for Severe Pulmonary Hypertension in Neonates and Infants

Amit V. Krishnan, Victoria Freniere, Rakesh Sahni, Diana P. Vargas Chaves, Sankaran S. Krishnan, Dimitrios Savva, Usha S. KrishnanColumbia University Irving Medical Center and New York-Presbyterian Hospital. New York Medical College.United States ChildrenChildren 2024; DOI: 10.3390/children11060703 AbstractThis is a single-center retrospective study to assess the safety and tolerability of continuous inhaled iloprost use as rescue therapy […]

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Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension?

Deepika Sankaran, Jessa Rose A. Li, Satyan LakshminrusimhaUniversity of California, Davis.United States ChildrenChildren 2024; DOI: 10.3390/children11060673 AbstractHypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality among term newborns globally. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome (MAS) and HIE. Simultaneous occurrence of MAS and HIE is a perilous combination

Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension? Read More »

Improvement in Echocardiographic and Diagnostic Biomarkers after Systemic Glucocorticoid Therapy in Infants with Pulmonary Hypertension

Brian S. Hernandez, Rod M. Shinozaki, R. Mark Grady, Andrea Drussa, Erica Jamro-Comer, Jinli Wang, Manish AggarwalWashington University School of Medicine. Loma Linda University Children’s Hospital. United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114116 AbstractObjective: To assess the effect of treating pulmonary hypertension (PH) in infants less than 1 year of age with systemic glucocorticoids while

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Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial

Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama DabbaghIran University of Medical Sciences. Shahid Akbar Abadi Hospital. Iran Pediatrics and NeonatologyPediatr Neonatol 2024; DOI: 10.1016/j.pedneo.2023.12.007 AbstractBackground: Persistent Pulmonary Hypertension of the newborn (PPHN) is characterized by sustained elevated Pulmonary Artery Pressure (PAP). Drug resistance and the adverse effects of current therapeutic agents warrant investigation of other

Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial Read More »

Severe Lymphatic Disorder and Multifocal Atrial Tachycardia Treated with Trametinib in a Patient with Noonan Syndrome and SOS1 Mutation

Michele Lioncino, Adelaide Fusco, Emanuele Monda, Diego Colonna, Martina Caiazza, Michelina Sibilio, Daniela Magri, Angela Carla Borrelli, Barbara D’Onofrio, Maria Luisa Mazzella, Rossella Colantuono, Maria Rosaria Arienzo, Berardo Sarubbi, Maria Giovanna Russo, Giovanni Chello, Giuseppe LimongelliUniversity of Campania “Luigi Vanvitelli” and Monaldi Hospital. University College of London and St. Bartholomew’s Hospital.Italy and United Kingdom GenesGenes

Severe Lymphatic Disorder and Multifocal Atrial Tachycardia Treated with Trametinib in a Patient with Noonan Syndrome and SOS1 Mutation Read More »

Management of Pulmonary Vascular Disease Associated with Congenital Left to Right Shunts: A Single Center Experience

Hythem Nawaytou, Ramya Lakkaraju, Leah Stevens, Vadiyala Mohan Reddy, Naveen Swami, Roberta L. Keller, David F. Teitel, Jeffrey R. FinemanUniversity of California,San Francisco.United States Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2024; DOI: 10.1016/j.jtcvs.2024.05.007 AbstractObjective: To describe the course and outcomes of children under 18 with left-to-right (LR) shunts and pulmonary arterial hypertension (PAH) undergoing

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Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial

Steven M. Kawut, Rui Feng, Susan S. Ellenberg, Roham Zamanian, Todd Bull, Murali Chakinala, Stephen C. Mathai, Anna Hemnes, Grace Lin, Margaret Doyle, Ruth Andrew, Margaret MacLean, Ioannis Stasinopoulos, Eric Austin, Angela DeMichele, Haochang Shou, Jasleen Minhas, Nianfu Song, Jude Moutchia, Corey E. VentetuoloUniversity of Pennsylvania Perelman School of Medicine. Stanford University Medical Center. University

Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial Read More »

Milrinone in persistent pulmonary hypertension of newborn: a scoping review

Radu Galis, Diane Mudura, Paula Trif, Shivashankar Diggikar, Arun Prasath, Maria Livia Ognean, Jan Mazela, Adrian Lacatusu, Rangasamy Ramanathan, Boris W. Kramer, Yogen SinghEmergency County Hospital Bihor. Poznan University of Medical Sciences. University of Oradea. Oyster Woman and Child Hospital. University of Texas Southwestern. Lucian Blaga University Sibiu. Clinical County Emergency Hospital Sibiu. Emergency County

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Selexipag Dosing Strategies for Pediatric Patients with Pulmonary Arterial Hypertension

Madeline Grossman, Stephen Walker, E. Zachary RamseyChildren’s Hospital of Philadelphia.United States Pediatric CardiologyPediatr Cardiol 2024; DOI: 10.1007/s00246-024-03513-w AbstractThis retrospective chart review of patients less than 18 years old with pulmonary arterial hypertension (PAH) receiving selexipag was conducted to describe selexipag dosing practices, impact on concomitant PAH therapies, and the safety and efficacy of selexipag. Twenty-seven patients

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Effect of prone positioning ventilation on pulmonary function in neonates during venous-arterial extracorporeal membrane oxygenation

Kai-Peng Sun, Si-Jia Zhou, Xiu-Hua Chen, Yi-Rong Zheng, Qiang ChenFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center) and Fujian Medical University.China Translational PediatricsTransl Pediatr 2024; 13: 575-583DOI: 10.21037/tp-23-485 AbstractBackground: The use of extracorporeal membrane oxygenation (ECMO) technology has significantly decreased mortality rates associated with neonatal pulmonary hypertension and respiratory failure. Prone positioning ventilation (PPV) is

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