Medical Therapy. Adverse Effects or Lack of Adverse Effects Archives

Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn

Sania El-HindiChildren’s Hospital of Damascus University.Syria World Journal of Clinical PediatricsWorld J Clin Pediatr 2026; 15: DOI: 10.5409/wjcp.118862 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) remains a challenging condition with high morbidity and mortality despite advancements in management, which implies the need to investigate new therapies. While sildenafil is the drug of choice in resource-limited centers […]

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Efficacy, Safety, and Pharmacokinetics of Macitentan in Japanese Pediatric Patients With Pulmonary Arterial Hypertension: Prospective, Multicenter, Open-Label Study

Ryo Inuzuka, Taku Ishii, Toru Iwasa, Kenichi Kurosaki, Ayako Kuraoka, Jun Narita, Shinichi Takatsuki, Masayoshi Nakano, Rieko Inagaki, Maki Mihoya, Kim Hyunsoo, Minaka Shibuya, Tohru Kobayashi, Hidekazu Ishida, Taichi Kato, Masaru Miura, Hiroyuki Yamagishi, Shozaburo DoiUniversity of Tokyo. Institute of Science Tokyo Hospital. National Cerebral and Cardiovascular Center. Fukuoka Children’s Hospital. University of Osaka Graduate

Efficacy, Safety, and Pharmacokinetics of Macitentan in Japanese Pediatric Patients With Pulmonary Arterial Hypertension: Prospective, Multicenter, Open-Label Study Read More »

Pulmonary hypertension and acute hypoxic respiratory failure in preterm neonates

Marwa M. Elgendy, Sfurti NathUniversity of Maryland School of Medicine. Warren Alpert Medical School of Brown University.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02858-9 AbstractPulmonary hypertension (PH) in preterm infants is a complex and heterogeneous condition that significantly contributes to hypoxic respiratory failure (HRF), bronchopulmonary dysplasia (BPD), and mortality. Unlike term infants, PH in preterm

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Vasopressin for hemodynamic support in neonates: current evidence and clinical applications

Aimann Surak, Mohamed Sewidan, Mimi T. Y. Kuan, Megan Kennedy, Manoj Kumar, Joseph Y. TingUniversity of Alberta. University of British Columbia. Canada Journal of PerinatologyJ Perinatol 2026;DOI: 10.1038/s41372-026-02837-0 AbstractObjective: To systematically map and synthesize the available evidence on the use of vasopressin for hemodynamic support in neonates.Study design: We conducted a scoping review to synthesize available data on

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Inhaled Nitric Oxide and Hypoxic Brain Injury in Newborn Piglets

Shadi Malaeb, John Grothusen, Ferit Tuzer, Maria Delivoria-PapadopoulosDrexel University College of Medicine. United States Nitric OxideNitric Oxide 2026; DOI: 10.1016/j.niox.2026.07.003 AbstractBackground: Inhaled nitric oxide (iNO) is widely used as a pulmonary vasodilator to treat infants with pulmonary hypertension (PHN). Hypoxia (Hx) and acidosis increase pulmonary vascular resistance and contribute to PHN. Perinatal asphyxia and resultant hypoxic-ischemic encephalopathy

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Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort

Catherine M. Avitabile, Kimberly Butler, Antara Mondal, David B. Frank, Yan Wang, Devon Ash, Laura Mercer‐Rosa, Michael L. O’Byrne, Ryan CallahanUniversity of Pennsylvania, Perelman School of Medicine and Children’s Hospital of Philadelphia. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70346 AbstractPulmonary hypertension (PH) and right ventricular (RV) dysfunction increase mortality in multivessel pediatric pulmonary vein

Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort Read More »

Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation

Weidi Xiao, Nedaa Aldairi, Brian S. Marcus, Matthew Weiss, Allison S. Cowl, Marissa Moncata, Akash Deep, Oliver KaramYale University, Yale New Haven Children’s Hospital and Yale School of Medicine. Dr. Sulaiman AlHabib Medical Group. Albert Einstein College of Medicine. Centre Mère-Enfant Soleil du CHU de Québec. Connecticut Children’s Medical Center. King’s College Hospital. United States,

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Off-Label Sotatercept Use in Pediatric Pulmonary Arterial Hypertension: A Single-Center Retrospective Hemodynamic Study

Dhruv Rao, Shylah Haldeman, Jeanne Carroll, Rohit RaoUniversity of Arizona, Tucson. Rady Children’s Hospital-San Diego and University of California San DiegoUnited States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04349-2 AbstractSotatercept, a first-in-class activin signaling inhibitor, has demonstrated disease-modifying efficacy in adults with pulmonary arterial hypertension (PAH). Pediatric data remain limited to ongoing clinical trials. We conducted an

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Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats

Guoliang Wang, Jie Liu, Peiyi Bai, Hong Jiao, Xiaohui Kong, Zhangke Guo, Gaopeng Li, Aijun LiuBeijing Children’s Hospital, Beijing Pediatric Research Institute, Capital Medical University and National Center for Children’s Health. Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences and Tongji Shanxi Hospital. General Hospital of Taiyuan Iron and

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Efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis

Guanghong Li, Xiaoqun Du, Weibin Luo, Junhua Wei, Huiyi HuangHuadu District People’s Hospital of Guangzhou.China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1836276 AbstractObjective: To evaluate the efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN).Methods: PubMed, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception to March

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