Medical Therapy. Adverse Effects or Lack of Adverse Effects

Use of sotatercept in an adolescent patient with idiopathic pulmonary arterial hypertension

Kohei Kurosaki, Yohei Akazawa, Tomoyasu Yuki, Kohta Takei, Kiyohiro TakigikuNagano Children’s Hospital. Japan Journal of Cardiology CasesJ Cardiol Cases 2026; 34: 173-176DOI: 10.1016/j.jccase.2026.06.010 AbstractAn adolescent boy with idiopathic pulmonary arterial hypertension (iPAH) presented with persistent pulmonary hypertension with right ventricular dysfunction despite upfront oral triple combination therapy. Additional sotatercept treatment led to a striking improvement

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Antithrombotic Therapy Use in Children With Pulmonary Hypertension

Meredith J. O’Neil, Lynn A. Sleeper, Nidhy P. Varghese, Paul J. Critser, Eric D. Austin, Catherine M. Avitabile, Angela Bates, Erika B. Rosenzweig, Carly E. Byrd, Patrick D. Evers, Stephanie S. Handler, Rachel K. Hopper, Emma O. Jackson, Roberta L. Keller, Usha S. Krishnan, Minmin Lu, Jessica Maclean, Raysa Morales‐Demori, Mary P. Mullen, Meredith Riker,

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Sotatercept in Pediatric Pulmonary Hypertension: Experience from the Pediatric Pulmonary Hypertension Network

Paul J. Critser, Usha S. Krishnan, Catherine M. Avitabile, Andrea L. Jones, Benjamin S. Frank, Dunbar D. Ivy, Emily P. Williams, Rachel T. Sullivan, Eric D. Austin, Dephine Yung, Stephanie S. Handler, Edward Kirkpatrick, Mary P. Mullen, Claire Parker, Megan Griffiths, Patrick D. Evers, Meredith J. O’Neil, Neelam D. Bhatt, Rachel Capote, Erika B. Rosenzweig,

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Pediatric subcutaneous treprostinil site maintenance and pain control strategies from the Pediatric Pulmonary Hypertension Network

Emma O. Jackson, Anna Brown, Julia McSweeney, Claire ParkerSeattle Children’s Hospital. Vanderbilt Children’s Hospital. Boston Children’s Hospital. University of California, San Francisco Benioff Children’s Hospital.United States Pulmonary CirculationPulm Circ 2021; 11: DOI: 10.1177/2045894021994450 AbstractPulmonary arterial hypertension is a chronic, progressive, and life-threatening disease in children with diverse causes of pulmonary arterial hypertension. The most severe

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Investigation of the Effects of Switching from Bosentan to Macitentan in Pediatric Pulmonary Hypertension Patients

Mustafa Mertkan Bilen, Timur Mese, Murat Muhtar Yilmazer, Gamze Vuran, Cem Dogan, Yusuf Ilker Dur, Ozan HiraUniversity of Health Sciences, Dr. Behcet Uz Pediatric Diseases And Surgery Training and Research Hospital.Turkey Medical Bulletin of Sisli Etfal Hospital Sisli Etfal Hastan Tip Bul 2026; 60: 405-411DOI: 10.14744/SEMB.2026.78803 AbstractObjectives: Pulmonary arterial hypertension (PAH) is a progressive disease

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Long-Term Subcutaneous Treprostinil in Pediatric Pulmonary Arterial Hypertension at a Latin American Referral Center: A Retrospective Cohort Study

Angelo Valencia Salazar, Ernesto León Vallejo MondragónClínica Imbanaco.Columbia Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70395 AbstractPediatric pulmonary arterial hypertension is a progressive vasculopathy with substantial early mortality. Subcutaneous treprostinil is an established prostacyclin-pathway therapy for higher-risk disease, but long-term pediatric data from Latin American referral centers remain limited. This retrospective cohort included all nine consecutive

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Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn

Sania El-HindiChildren’s Hospital of Damascus University.Syria World Journal of Clinical PediatricsWorld J Clin Pediatr 2026; 15: DOI: 10.5409/wjcp.118862 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) remains a challenging condition with high morbidity and mortality despite advancements in management, which implies the need to investigate new therapies. While sildenafil is the drug of choice in resource-limited centers

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Efficacy, Safety, and Pharmacokinetics of Macitentan in Japanese Pediatric Patients With Pulmonary Arterial Hypertension: Prospective, Multicenter, Open-Label Study

Ryo Inuzuka, Taku Ishii, Toru Iwasa, Kenichi Kurosaki, Ayako Kuraoka, Jun Narita, Shinichi Takatsuki, Masayoshi Nakano, Rieko Inagaki, Maki Mihoya, Kim Hyunsoo, Minaka Shibuya, Tohru Kobayashi, Hidekazu Ishida, Taichi Kato, Masaru Miura, Hiroyuki Yamagishi, Shozaburo DoiUniversity of Tokyo. Institute of Science Tokyo Hospital. National Cerebral and Cardiovascular Center. Fukuoka Children’s Hospital. University of Osaka Graduate

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Pulmonary hypertension and acute hypoxic respiratory failure in preterm neonates

Marwa M. Elgendy, Sfurti NathUniversity of Maryland School of Medicine. Warren Alpert Medical School of Brown University.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02858-9 AbstractPulmonary hypertension (PH) in preterm infants is a complex and heterogeneous condition that significantly contributes to hypoxic respiratory failure (HRF), bronchopulmonary dysplasia (BPD), and mortality. Unlike term infants, PH in preterm

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Vasopressin for hemodynamic support in neonates: current evidence and clinical applications

Aimann Surak, Mohamed Sewidan, Mimi T. Y. Kuan, Megan Kennedy, Manoj Kumar, Joseph Y. TingUniversity of Alberta. University of British Columbia. Canada Journal of PerinatologyJ Perinatol 2026;DOI: 10.1038/s41372-026-02837-0 AbstractObjective: To systematically map and synthesize the available evidence on the use of vasopressin for hemodynamic support in neonates.Study design: We conducted a scoping review to synthesize available data on

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