Review Articles Concerning Pulmonary Vascular Disease

Management of Hypoxemic Respiratory Failure in the Newborn During Therapeutic Hypothermia

Paulina Hume, Luna Khanal, Satyan Lakshminrusimha, Deepika SankaranUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2026; 53: 317-332DOI: 10.1016/j.clp.2026.02.008 AbstractTherapeutic hypothermia (TH) is the gold standard for the management of hypoxic ischemic encephalopathy (HIE) in newborns. Both hypoxia and TH may contribute to an increase in pulmonary vascular resistance (PVR), resulting in persistent pulmonary hypertension

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Advances in the Management of Persistent Pulmonary Hypertension of the Newborn

Emily Mooers, Satyan Lakshiminrusimha, G. Ganesh KonduriMedical College of Wisconsin and Children’s Wisconsin. University of California and UC Davis Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 297-316DOI: 10.1016/j.clp.2026.02.003 AbstractThis article details an integrated approach to optimize management strategies for hypoxemic respiratory failure and hemodynamic instability in persistent pulmonary hypertension of the newborn (PPHN). Even

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Respiratory Management for the Infant with Congenital Diaphragmatic Hernia

Michelle J. Yang, Matthew Douglass, Ryan J. Carpenter, Bradley A. YoderUniversity of Utah School of Medicine and Primary Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 277-295DOI: 10.1016/j.clp.2026.02.002 AbstractCongenital diaphragmatic hernia (CDH) is a complex neonatal condition characterized by pulmonary hypoplasia and pulmonary hypertension, requiring specialized ventilatory management from birth through postoperative care. This article

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The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia

Amed Soliz, Jorge SolizFlorida International University and Memorial Regional Hospital. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) and Université Laval. Altitude Baby Association. United States and Canada Respiratory Physiology and NeurobiologyRespir Physiol Neurobiol 2026;DOI: 10.1016/j.resp.2026.104609 AbstractHigh altitude exposes the human fetus and newborn to chronic hypobaric hypoxia, markedly reducing oxygen availability during critical

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Unveiling the Link Between COVID-19 and Pulmonary Hypertension

Jad Abdul Khalek, Mohamad Al Hajjar, Zeina Al-Khalil, Jana Salem, Rana Zareef, Fadi Bitar, Mariam ArabiAmerican University of Beirut Medical Center and American University of Beirut.Lebanon Canadian Journal of Infectious Diseases and Medical MicrobiologyCan J Infect Dis Med Microbiol 2026; DOI: 10.1155/cjid/9352258 AbstractIntroduction: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, was first identified in Wuhan, China,

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Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with

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Risk Stratification and Fetal Therapies for Congenital Diaphragmatic Hernia

Connor V. Haynes, David H. StitelmanYale New Haven Children’s Hospital,United States NeoreviewsNeoreviews 2026; DOI: 10.1542/neo.27-6-021 AbstractCongenital diaphragmatic hernia (CDH) remains one of the most challenging congenital anomalies encountered by neonatologists and pediatric surgeons, with outcomes largely determined before birth. Although surgical repair of the diaphragmatic defect is essential, postnatal morbidity and mortality are primarily driven by

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Breathing challenges in achondroplasia: a comprehensive review of pediatric respiratory complications

Veronica Fasoli, Alessia Mariani, Federica Chironi, Mara Lelii, Barbara Madini, Beatrice Andrenacci, Alessia Rocchi, M. Francesca Bedeschi, M. Gaffuri, M. Pluderi, M. Francesca PatriaUniversità Degli Studi di Milano. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Italy Paediatric Respiratory ReviewsPaediatr Respir Rev 2026; DOI: 10.1016/j.prrv.2026.05.003 AbstractAchondroplasia is the most common skeletal dysplasia, characterized by disproportionate short stature

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Association between upper airway obstruction and pulmonary hypertension in children with Down syndrome

Kevin Guy, Amal IsaiahUniversity of Maryland School of Medicine.United States Current Opinion in Pulmonary MedicineCurr Opin Pulm Med 2026; DOI: 10.1097/MCP.0000000000001287 AbstractPurpose of review: Down syndrome (DS) is the most common nonlethal chromosomal aneuploidy, affecting 1 in 700 live births. Pulmonary hypertension (PH) occurs in approximately 25% of children with DS and contributes to a 10% mortality

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Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models

Siqi She, Debao Li, Qi Sun, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China ChildrenChildren 2026; 13: DOI: 10.3390/children13050677 AbstractPulmonary vein stenosis (PVS) is a rare and devastating condition affecting infants and children, characterized by progressive intimal hyperplasia, myofibroblast proliferation,

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