Review Articles Concerning Pulmonary Vascular Disease

An Approach to Children with Pulmonary Edema at High Altitude

Deborah R. Liptzin, Steven H. Abman, Ann Giesenhagen, D. Dunbar IvyUniversity of Colorado School of Medicine and Children’s Hospital ColoradoUnited States High Altitude Medicine and BiologyHigh Altit Med Biol 2018;DOI: 10.1089/ham.2017.0096 AbstractIntroduction: Diagnosis of high-altitude illness can be more challenging in children, especially those who are preverbal. Families often travel to high elevations for family vacations, either […]

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Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles

Usha S. Krishnan, Mary P. MullenVagelos College of Physicians and Surgeons of Columbia University Irving Medical Center and Morgan Stanley Children’s Hospital of New York Presbyterian. Boston Children’s Hospital and Harvard Medical School. United States Comprehensive Physiology Interorgan Communication in Health and DiseaseCompre Physiol 2025; DOI: 10.1002/cph4.70085 AbstractUnderstanding communication between various organ systems is vital to

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Transcatheter Management of Pulmonary Vein Stenosis in Children

Connie Choi, Ryan CallahanSeattle Children’s Hospital. Children’s Hospital of Philadelphia. United States Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04130-x AbstractPediatric intraluminal pulmonary vein stenosis (PVS) is a challenging condition where the diagnosis is confirmed via cardiac catheterization. The patient population is complex with inherent hemodynamic vulnerabilities, and the high rate of restenosis necessitates recurrent, technically demanding transcatheter

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Use of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors in Pulmonary Hypertension

Benoit Aguado, Grégoire Ruffenach, Thomas Lacoste-Palasset, Agnes Görlach, Marianne Riou, Mathieu Gourmelon, Fabrice Bauer, Marc Humbert, Valerie Schini-Kerth, Jean-Luc Vachiéry, David Montani, Fabrice AntignyUniversité Paris-Saclay and French National Institute for Health and Medical Research. Hôpital Bicêtre and Hôpital Marie Lannelongue. Technical University Munich and German Centre for Cardiovascular Research. Nouvel Hôpital Civil and University Hospital

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Treatable Traits in Pediatric Interstitial Lung Diseases: Bridging the Gap to Tailored Therapeutics

Giuseppe Fabio Parisi, Maria Papale, Giulia Pecora, Santiago Presti, Monica Tosto, Salvatore LeonardiSan Marco Hospital and University of Catania.Italy Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14228190 AbstractPediatric interstitial lung diseases (chILD) are a diverse and complex group of rare but impactful disorders characterized by heterogeneous etiologies and variable clinical courses. Traditional diagnosis-based management

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Cardiology Overview of Pulmonary Hypertension Management in the Neonatal Intensive Care Unit

Rebecca J. Kameny, Rachel K. HopperStanford University.United States Clinics in PerinatologyClin Perinatol 2025; 52: 633-653DOI: 10.1016/j.clp.2025.08.002 AbstractPulmonary hypertension (PH) in the neonatal intensive care unit represents a complex and diverse spectrum of conditions, from transient persistent pulmonary hypertension of the newborn to chronic PH associated with bronchopulmonary dysplasia, congenital heart disease, and other conditions, and can

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Atrial Septal Defects: From Embryology to Pediatric Pulmonary Hypertension

Elzbieta Bartoszewska, Anna Chrapkowska, Oliwia Zielinska, Maria Mordalska, Julia Lizon, Zuzanna Zalewska, Marek WasicionekWroclaw Medical University. Poland Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14217698 AbstractAtrial septal defect (ASD) is characterized by an abnormal opening between the left (LA) and right atria (RA). Even though it’s one of the most prevalent congenital heart defects,

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Pulmonary vascular complications in children who survive long-term after Kasai portoenterostomy for biliary atresia: a narrative review

Jie Zhang, Gong ChenChildren’s Hospital of Fudan University.China World Journal of Pediatric SurgeryWorld J Pediatr Surg 2025; 8: DOI: 10.1136/wjps-2025-001067 AbstractFollowing Kasai portoenterostomy for biliary atresia (BA), long-term survival in children is associated with chronic liver cirrhosis leading to hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH). This further causes a diverse array of respiratory and circulatory

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Kidney and vascular involvement in Alagille syndrome

Bruno Ranchin, Marie‑Noelle Meaux, Malo Freppel, Mathias Ruiz, Aurelie De MulHôpital Femme Mère Enfant, Hospices Civils de Lyon and Université de Lyon.France Pediatric NephrologyRediatr Nephrol 2025; 40: 891-899DOI: 10.1007/s00467-024-06562-8 AbstractAlagille syndrome (ALGS) is an autosomal dominant, multisystemic disease with a high interindividual variability. The two causative genes JAG1 and NOTCH2 are expressed during kidney development, can

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Treatment options for children with pulmonary arterial hypertension associated with congenital heart disease

Julie Wacker, Raphael Joye, Maurice BeghettiGeneva University Hospitals.Switzerland Expert Review of Respiratory MedicineExpert Rev Respir Med 2025; DOI: 10.1080/17476348.2025.2581340 AbstractIntroduction: Pulmonary hypertension associated with congenital heart disease (PAH-CHD) represents one of the leading causes of pediatric pulmonary hypertension. Within this entity, patients can be classified into distinct subgroups, each characterized by specific clinical features, pathophysiological mechanisms, and

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