Boshen Shu, Xiaohui Wang, Richard Wagner, Florian Friedmacher, Martin Lacher, Ophelia Aubert
Henan Provincial People’s Hospital. University of Leipzig. University Hospital Frankfurt and Goethe University Frankfurt. University Medical Center Mannheim and University of Heidelberg.
China and Germany
Pediatric Surgery International
Pediatr Surg Int 2026; 42:
DOI: 10.1007/s00383-026-06597-y
Abstract
Background: Research models of congenital diaphragmatic hernia (CDH) have evolved over time. We aimed to evaluate global research activities in CDH models using bibliometric analysis over the past three decades.
Methods: Studies were retrieved from the Web of Science Core Collection (WoSCC) database between 1995 and 2024. Microsoft Excel, GraphPad Prism, and VOSviewer were applied to collect and analyze the bibliometric variables of this field.
Results: A total of 302 original publications from 21 countries were identified. The nitrofen rat model (n = 187) was used in most studies, followed by sheep (n = 44), and rabbit (n = 32) models. The use of mouse models increased over time. The USA leads with the highest number of publications (n = 78) and collaborations, and the Journal of Pediatric Surgery published most articles. Main publication topics were developmental biology, pulmonary hypertension and surgical techniques. “Congenital diaphragmatic hernia”, “Nitrofen”, and “Pulmonary hypoplasia” were the most frequent keywords, while “Sildenafil”, “Mice”, and “Endothelial” were recent research hotspots.
Conclusion: CDH research model has developed rapidly with increased collaborations and model diversity. Areas of interest varied, with a focus on developmental biology. Mouse models may gain importance to investigate genetic and molecular mechanisms of CDH.
Category
Class III. Pulmonary Hypertension Associated with Lung Hypoplasia
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes