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Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets

MengzeWang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie DingKunming Children’s Hospital. Southern Medical University. Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Taizhou Central Hospital (Taizhou University Hospital). Second Hospital of Jiaxing and Second Affiliated Hospital of Jiaxing University. Zhejiang Rongjun Hospital. […]

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets Read More »

Pediatric Lung Transplantation in Israel: 29 Cases from a Single Center’s Experience

Eyal Jacobi, Moshe Heching, Osnat Shtraichman, Dror Rosengarten, Barak Pertzov, Ophir Bar-On, Hagit Levine, Ofer Schiller, Yury Peysakhovich, Dario Prais, Yaron Barac, Mordechai Reuven KramerSchneider Children’s Medical Center, Rabin Medical Center, Gray Faculty of Medical and Health Sciences and Tel Aviv University. Israel Israel Medical Association JournalIsrael Med Assoc J 2025; 27: 778-782DOI: Not Available

Pediatric Lung Transplantation in Israel: 29 Cases from a Single Center’s Experience Read More »

Reversible Pulmonary Hypertension in CblC Deficiency (MMACHC c.80 A>G): long-term outcomes of metabolic and PH-targeted therapy

Ruxuan He, Jinrong Liu, Xiaolei Tang, Hui Liu, Yuelin Shen, Xioayan Zhang, Huimin Li, Shunying Zhao, Haiming YangBeijing Children’s Hospital and Capital Medical University. Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children’s Hospital and Seventh People’s Hospital of Xinjiang Uygur Autonomous Region.China Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04720-8 AbstractBackground: Cobalamin C (cblC) deficiency,

Reversible Pulmonary Hypertension in CblC Deficiency (MMACHC c.80 A>G): long-term outcomes of metabolic and PH-targeted therapy Read More »

SOX17 variants are associated with severe pulmonary arterial hypertension with and without congenital heart disease

Cara Morgan, Laura Southgate, Alistair Calder, Thivya Sekar, Andrew Constantine, Sadia Quyam, Richard Trembath, Shahin MoledinaGreat Ormond Street Hospital for Children. University of London, School of Health & Medical Sciences. Queen Elizabeth Hospital Birmingham. University College London. King’s College London. United Kingdom International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.134114 AbstractBackground: SOX17 has recently been identified

SOX17 variants are associated with severe pulmonary arterial hypertension with and without congenital heart disease Read More »

Six cases of ENPP1 pathogenic variants causing autosomal recessive hypophosphatemic rickets type 2 and generalized arterial calcification of infancy

Lucy Collins, Jessica Sandy, Stephanie Ly, Kate E. Lomax, Sarah Black, Fiona McKenzie, Eadaoin Hayes, Cathryn Poulton, Craig Jefferies, Wendy Hunter, Peter Simm, Christine Rodda, Andrew Biggin, Craig Munns, Aris SiafarikasRoyal Children’s Hospital. Monash University. Children’s Hospital at Westmead. University of Sydney. Perth Children’s Hospital. University of Western Australia. King Edward Memorial Hospital. Starship Children’s

Six cases of ENPP1 pathogenic variants causing autosomal recessive hypophosphatemic rickets type 2 and generalized arterial calcification of infancy Read More »

Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

Claudia Mickael, Jane C. Kabwe, Dara Fonseca Balladares, Annika S. Bai, Kevin Nolan, Michael H. Lee, Rahul Kumar, Joan F. Hilton, Joseph Phiri, Taonga Musonda, Katie Tuscan, Linda Sanders, Kurt R. Stenmark, Paul W. Buehler, Edford Sinkala, David C. Irwin, Sula Mazimba, Brian B. GrahamUniversity of Colorado Anschutz Medical Campus. National Heart Hospital Lusaka and

Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis Read More »

A prospective, multicenter, open-label, single-arm Phase 2 study to investigate the pharmacokinetics, safety, tolerability, and exploratory efficacy of selexipag in children with pulmonary arterial hypertension

Maurice Beghetti, Lene Nygaard Axelsen, Julian I. Borissoff, Mahdi Farhan, Simon Grill, Sining Leng, Alberto Russu, Catherine Lesage, Tatiana Remeňová, Shu-Fang Hsu Schmitz, Shahin MoledinaUniversity Hospitals of Geneva. Johnson & Johnson. Great Ormond Street Hospital. Switzerland and United Kingdom ChestChest 2025; DOI: 10.1016/j.chest.2025.12.013 AbstractBackground: Selexipag is an oral selective prostacyclin receptor agonist approved for treating pulmonary arterial

A prospective, multicenter, open-label, single-arm Phase 2 study to investigate the pharmacokinetics, safety, tolerability, and exploratory efficacy of selexipag in children with pulmonary arterial hypertension Read More »

Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles

Usha S. Krishnan, Mary P. MullenVagelos College of Physicians and Surgeons of Columbia University Irving Medical Center and Morgan Stanley Children’s Hospital of New York Presbyterian. Boston Children’s Hospital and Harvard Medical School. United States Comprehensive Physiology Interorgan Communication in Health and DiseaseCompre Physiol 2025; DOI: 10.1002/cph4.70085 AbstractUnderstanding communication between various organ systems is vital to

Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles Read More »

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study

Feng Xie, Philip Chung, Jonathan D. Reiss, Erico Tjoa, Davide De Francesco, Thanaphong Phongpreecha, William Haberkorn, Dipro Chakraborty, Alan Lee Chang, Tomin James, Yeasul Kim, Samson Mataraso, Camilo Espinosa, Liu Yang, Chi-Hung Shu, Lei Xue, Eloïse Berson, Neshat Mohammadi, Sayane Shome, S Momsen Reincke, Marc Ghanem, Ivana Maric, Brice Gaudilliere, Martin S Angst, Karl Sylvester,

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study Read More »

Reduction in Prostacyclin Infusion Errors Following a Comprehensive Multidisciplinary Process Transformation for Hospitalized Pediatric Patients with Pulmonary Hypertension: A Quality Improvement Project

Christa Kirk, Anne Davis, Delphine YungDuquesne University School of Pharmacy. Seattle Children’s Hospital. University of Washington School of Medicine.United States Journal of Pediatric Pharmacology and TherapeuticsJ Pediatr Pharmacol Ther 2025; 30: 800-806DOI: 10.5863/JPPT-25-00033 AbstractObjective: Owing to a rise in potentially serious errors with parenteral prostacyclin infusions associated with using an unfamiliar MedFusion 3500 syringe pump (MedFusion), we

Reduction in Prostacyclin Infusion Errors Following a Comprehensive Multidisciplinary Process Transformation for Hospitalized Pediatric Patients with Pulmonary Hypertension: A Quality Improvement Project Read More »

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