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Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Screening and Management

Samuel F. Schaeffer, Bwaar Omer, Akshaya Vachhaarajani, Chaitanya PanchangamUniversity of Missouri.United States NeoreviewsNeoreviews 2025; 26: e316-e327DOI: 10.1542/neo.26-5-013 AbstractScreening for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD) was recommended by the American Thoracic Society in 2015. However, the definition of BPD has since changed. This review summarizes the current definition of BPD, the recommendations and […]

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Different Effects of Riociguat and Vericiguat on Pulmonary Vessels and Airways

Katharina Nubbemeyer, Julia Krabbe, Svenja Böll, Anna Michely, Sebastian Kalverkamp, Jan Spillner, Christian MartinRWTH Aachen University. Ruhr University Bochum. Germany BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13040856 AbstractBackground/Objectives: Pulmonary hypertension is a progressive disease leading to right heart failure. One treatment strategy is to induce vasodilation via the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway. There

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Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes

Renping Mao, Weiwei Ruan, Jianming Zhu, Li Li, Haiyan Jiang, Yanhong LiAffiliated Women and Children’s Hospital of Ningbo University.China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1511892 AbstractBackground: Congenital hepatic hemangioma with arteriovenous fistula (HHAVF) is a rare condition in newborns that may manifest as respiratory distress, pulmonary hypertension, and heart failure shortly after birth. This report

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Retinal detachment in a neonate with congenital chylothorax and purpura fulminans associated with the PAK2 genetic variant: A case report

Arijit Lodha, Majeeda Kamaluddeen, Stephanie Dotchin, Julie Lauzon, Patrick MitchellUniversity of Alberta. Cumming School of Medicine, University of Calgary. Canada International Journal of Surgery Case ReportsInt J Surg Case Rep 2025; 130: DOI: 10.1016/j.ijscr.2025.111341 AbstractIntroduction and importance: A potential relationship between bilateral retinal detachment, chylothorax, and purpura fulminans in a female neonate with a PAK2 gene variant

Retinal detachment in a neonate with congenital chylothorax and purpura fulminans associated with the PAK2 genetic variant: A case report Read More »

Lymphaticovenous and Lymph Node-to-Vein Anastomosis to Improve Milroy Disease-Related Chylothorax and Lymphedema

Feres Alshomer, Jeongmok Cho, Hyungjoo Noh, Changsik John Pak, Hyunsuk Peter Suh, Joon Pio HongUniversity of Ulsan College of Medicine and Seoul Asan Medical Center.Republic of Korea Plastic and Reconstructive SurgeryPlast Reconstr Surg 2025; 155: 610e-617eDOI: 10.1097/PRS.0000000000011635 AbstractBackground: Primary lymphedema is characterized by lymphatic dysplasia in which one variant is Milroy disease. The association with congenital chylothorax

Lymphaticovenous and Lymph Node-to-Vein Anastomosis to Improve Milroy Disease-Related Chylothorax and Lymphedema Read More »

Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models

Mikala C. Mueller, Rachel Blomberg, Alicia E. Tanneberger, Duncan Davis-Hall, Keith B. Neeves, Chelsea M. MaginUniversity of Colorado. United States American Chemical Society Biomaterials Science and EngineeringACS Biomater Sci Eng 2025; DOI: 10.1021/acsbiomaterials.5c00123 AbstractPulmonary arterial hypertension (PAH) is a form of pulmonary vascular disease characterized by scarring of the small blood vessels that results in reduced

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Factors Associated with Early-Childhood Ipsilateral Perfusion Abnormalities among Patients with Congenital Diaphragmatic Hernia

Akila B. Ramaraj, Hannah V. Breitschopf, Kylie I. Holden, Vikas S. Gupta, Carrie L. Foster, Ashley H. Ebanks, Chase M. Miller, Terry L. Buchmiller, Matthew T. Harting, Rebecca A. Stark, CDH Study GroupSeattle Children’s Hospital and UConn Health. McGovern Medical School at the University of Texas Health Science Center and Children’s Memorial Hermann Hospital. Boston

Factors Associated with Early-Childhood Ipsilateral Perfusion Abnormalities among Patients with Congenital Diaphragmatic Hernia Read More »

Performance of oral Bosentan-loaded SNEDDS and S-SNEDDS tablets: Biodistribution in mice, echocardiography and histology studies in pulmonary arterial hypertension rat model

Duygu Yilmaz Usta, Seval Olgac, Murside Ayse Demirel, Serdar Kula, Cigdem Elmas, Perihan Sezginer, Akif Kavgaci, Zeynep Safak TeksinGazi University. Alanya Alaadin Keykubat University. Turkey European Journal of Pharmaceutics and BiopharmaceuticsEur J Pharma Biopharma 2025; DOI: 10.1016/j.ejpb.2025.114725 AbstractBosentan monohydrate (BOS) is the most preferred molecule for treating the rare pulmonary arterial hypertension (PAH) disease. BOS shows

Performance of oral Bosentan-loaded SNEDDS and S-SNEDDS tablets: Biodistribution in mice, echocardiography and histology studies in pulmonary arterial hypertension rat model Read More »

Ductus Arteriosus Patency for the Hemodynamic Management of Newborns With Pulmonary Hypertension on Veno-Venous Extracorporeal Membrane Oxygenation

Andrea Moscatelli, Isabella Buffoni, Maria E. Derchi, Francesca Bagnasco, Francesca Febbo, Elisabetta Lampugnani, Stefano Pezzato, Stefania Bianzina, Camilla Micalizzi, Lara Petrucci, Silvia Buratti, Ravi R. ThiagarajanIRCCS Istituto Giannina Gaslini. Boston Children’s Hospital.Italy and United States American Society for Artificial Internal Organs JournalASAIO J 2025;DOI: 10.1097/MAT.0000000000002437 AbstractIn neonates with pulmonary hypertension (PH) supported on veno-venous extracorporeal membrane

Ductus Arteriosus Patency for the Hemodynamic Management of Newborns With Pulmonary Hypertension on Veno-Venous Extracorporeal Membrane Oxygenation Read More »

The Challenge in Burden of Pulmonary Arterial Hypertension: A Perspective From the Global Burden of Disease Study

Yicheng Yang, Zhiwei Zeng, Qiaoxi Yang, Huan Wang, Hanwen Zhang, Wenjie Yan, Peizhi Wang, Chuangshi Wang, Zhanhao Su, Pugazhenthan Thangaraju, Sher Zaman Safi, Beilan Yang, Yaoyao Wang, Jingjing Zhou, Zhiyong Zou, Yuan Huang, Songren Shu, Changming XiongFuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College. Anzhen Hospital

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