Jennifer A. Wambach, F. Sessions Cole, Lawrence M. Nogee
Washington University School of Medicine and St. Louis Children’s Hospital. Johns Hopkins University.
United States
Clinics in Perinatology
Clin Perinatol 2026; 53: 381-401
DOI: 10.1016/j.clp.2026.03.003
Abstract
Hypoxemic respiratory failure is a common reason for admission to the neonatal intensive care unit for term and late preterm infants. Some infants have rare disorders due to genetic mechanisms including surfactant dysfunction disorders, alveolar capillary dysplasia with misalignment of the pulmonary veins, and other developmental lung disorders that result in more severe, persistent, and even fatal disease. In this article, we summarize clinical characteristics of the most common causes of neonatal respiratory failure and of rare genetic causes, to help clinicians differentiate between common and rare causes and to aid in clinical decision-making including timing of genetic testing.
Category
Class III. Pulmonary Hypertension Associated with Developmental Diseases of the Lung
Review Articles Concerning Pulmonary Vascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: No