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Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype

Charles C. T. Hindmarch, Francois Potus, Ruaa Al-Qazazi, Benjamin P. Ott, William C. Nichols,Michael J. Rauh, Stephen L. ArcherQueen’s University. Universitaire de Cardiologie et de Pneumologie de Québec. Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine.Canada and United States Comprehensive PhysiologyCompr Physiol 2025; 15: DOI: 10.1002/cph4.70011 AbstractEpigenetic changes in gene expression due […]

Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype Read More »

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension

Bahram Mirani, John D. Dauz, Kana Yazaki, Neda Latifi, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergUniversity of Toronto, Ted Rogers Centre for Heart Research and Hospital for Sick Children. Beth Israel Deaconess Medical Center and Harvard Medical School. University of South Florida.Canada and United States Arteriosclerosis, Thrombosis and Vascular BiologyArterioscler,

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension Read More »

MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb

Xiang-Qun Hu, Rui Song, Chiranjib Dasgupta, Stephen Twum-Barimah, Taiming Liu, Abu Ahmed, Shawn F. Hanson, Lubo Zhang, Arlin B. BloodLoma Linda University School of Medicine.United States HypertensionHypertension 2025; DOI: 10.1161/HYPERTENSIONAHA.124.23061 AbstractBackground: Pulmonary hypertension of the newborn is a life-threatening disorder characterized by elevated pulmonary vascular resistance due to maladaptation of the pulmonary circulation after birth. The etiology

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GATA2 Deficiency With Early-Onset and Progressive Interstitial Lung Disease

Yuriko Sugiura, Takahiro Ando, Hirokazu Urushiyama, Akihisa Mitani, Goh Tanaka, Kenichi Kashimada, Tomohiro Morio, Hidenori KageUniversity of Tokyo. Institute of Science Tokyo.Japan Respirology Case ReportsRespirol Case Rep 2025; 13: DOI: 10.1002/rcr2.70165 AbstractGATA2 deficiency is a rare disease caused by germline heterozygous variants. This mutation is known to cause a decrease in haematopoietic stem cells and a

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Reduced Right Ventricular Size and Function in Adolescents and Adults Born Preterm

Zachary W. Blair, Alvin Chandra, Gregory P. Barton, Nataly Sanchez Solano, Jarett D. Berry, Kara N. GossUniversity of Texas Southwestern Medical Center. Parkland Health. University of Texas Health Tyler. United States Journal of the American Society of EchocardiographyJ Am Soc Echocardiogr 2025; DOI: 10.1016/j.echo.2025.04.007 AbstractBackground: Adults born premature have smaller cardiac chamber sizes, and some develop right

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Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1-7) Alone is Insufficient

James West, Megha Talati, Erica Carrier, Anandharajan Rathinasabapathy, Ibragim Gaidarov, Benjamin Vigl, Ying Cai, Hongpeng Jia, Tom Blackwell, Santhi Gladson, Christie Moore, Sheila Shay, Ethan Sevier, Anna HemnesVanderbilt University Medical Center. Eurofins Beacon Discovery. Alterras Therapeutics. Johns Hopkins University School of Medicine.United States and Austria Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70083 AbstractACE2 has shown effectiveness

Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1-7) Alone is Insufficient Read More »

Vasculopathy among children and adolescents with sickle cell disease: the crosstalk with annexin A1, vitamin D, and myocardial iron overload

Mohsen Saleh ElAlfy, Eman Abdel Rahman Ismail, Sara Mostafa Makkeyah, Ahmed Samir, Dina Husseiny Salama, Nanis Mohammed Salah Eldin, Dina Mohamed Fathy ElMaghraby, Nada Ayman Gad, Marwa Fath Ahmed Ali, Fatma Soliman El-Sayed EbeidAin Shams University. National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority. Minia UniversityEgypt Expert Review of HematologyExpert Rev Hematol

Vasculopathy among children and adolescents with sickle cell disease: the crosstalk with annexin A1, vitamin D, and myocardial iron overload Read More »

Trans-splenic catheterization for congenital extrahepatic portosystemic shunt embolization treating hepatopulmonary syndrome: A case report

Emre Can Çelebioglu, Emre Utkan Buyukceran, Sede Kaynak Sahap, Fazilcan Zirek, Nazan Çobanoglu, Suat Fitoz, Sadik BilgiçAnkara University Faculty of Medicine. Igdır State Hospita. Turkey Science ProgressSci Prog 2025; DOI: 10.1177/00368504251333521 AbstractCongenital extrahepatic portosystemic shunt (CEPS) is a rare vascular malformation, classified into type I (complete absence of the portal vein) and type II (presence of

Trans-splenic catheterization for congenital extrahepatic portosystemic shunt embolization treating hepatopulmonary syndrome: A case report Read More »

Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension

Rebecca L. Harper, Xin Zhou, David P. Marciano, Aiqin Cao, Lingli Wang, Guibin Chen, Mir S. Adil, Wenyu Zhou, Peter Maguire, Shanthi Deivanayagam, Quan Yu, Vignesh Viswanathan, Dan Yang, Marcy Martin, Sarasa Isobe, Shoichiro Otsuki, Jordan Burgess, Audrey Inglis, Devon Kelley, Patricia A. del Rosario, Andrew Hsi, Francois Haddad, Roham T. Zamanian, Manfred Boehm, Michael

Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension Read More »

Unilateral Pulmonary Vein Atresia in a Child

Jia-Bei Liu, Peng LiuFirst Affiliated Hospital of Hunan Normal University and Hunan Provincial People’s Hospital.China Pediatric PulmonologyPediatr Pulmonol 2025; 60:DOI: 10.1002/ppul.27378 AbstractWe describe a case of unilateral pulmonary vein atresia in a child who presented with a recurrent cough. Pulmonary artery CT angiography confirmed the diagnosis. In addition, we found anomalous blood-supplying arteries from the abdominal

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