Fresh (PHresh). Less than 1-2 years since publication

“Gentle” cardio-respiratory management in congenital diaphragmatic hernia: Time for a precision-medicine approach?

Anna Foth, David Tingay, Florian KipfmuellerUniversity Medical Center Mannheim and Heidelberg University. Murdoch Children’s Research Institute and University of Melbourne. Germany and Australia Seminars in Fetal and Neonatal MedicineSemin Fetal Neonatal Med 2025; DOI: 10.1016/j.siny.2025.101660 AbstractCongenital diaphragmatic hernia (CDH) remains one of the most challenging conditions to manage in neonatal intensive care, with outcomes determined by

“Gentle” cardio-respiratory management in congenital diaphragmatic hernia: Time for a precision-medicine approach? Read More »

Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice

Luca Zazzeron, Kakeru Shimoda, Paul Lichtenegger, Elizabeth Moore, Helena Tattersfield, Alexandra K. Marenco, Jiayi Kang, Haobo Li, Eizo Marutani, Donald B. Bloch, Fumito IchinoseMassachusetts General Hospital and Harvard Medical School. United States Journal of the American Heart AssociationJ Am Heart Assoc 2025; DOI: 10.1161/JAHA.125.042608 AbstractBackground: In children born at high altitude, lung development is affected by hypoxia, which can lead to pulmonary hypertension and right ventricular failure.

Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice Read More »

Haemoptysis caused by the absence of the right pulmonary vein in an 11-year-old child: a case report and literature review

Lili Wang, Lin Zhong, Lina Chen, Hanmin LiuWest China Second University Hospital and Sichuan University.China BioMedical Central PediatricsBMC Pediatr 2025; 25:DOI: 10.1186/s12887-025-06152-z AbstractBackground: The absence of the pulmonary vein is a rare congenital cardiovascular anomaly. It is most commonly diagnosed in infants, and diagnosis in adolescence is rare. Here, we report the case of an 11-year-old girl

Haemoptysis caused by the absence of the right pulmonary vein in an 11-year-old child: a case report and literature review Read More »

Congenital extrahepatic portosystemic shunt with partial anomalous pulmonary venous return and aneurysmal dilation of the pulmonary artery: successful management of a complex multisystem congenital anomaly

Sweta Mohanty, Shreesha Maiya, Dheeraj Kumar TiwariNarayana Health.India Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125109220 AbstractCongenital extrahepatic portosystemic shunt (CEPS) is an uncommon condition in which the portal vascular system drains into the systemic veins. We describe an unusual case of CEPS with congenital heart disease, presenting with aneurysmal enlargement of the pulmonary artery and

Congenital extrahepatic portosystemic shunt with partial anomalous pulmonary venous return and aneurysmal dilation of the pulmonary artery: successful management of a complex multisystem congenital anomaly Read More »

Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study

Hamdy El-Sayed, Hala Elmarsafawy, Basma Shouman, Mostafa Mansour, Amal OsmanMansoura University.Egypt Archive de PédiatrieArch Pediatr 2025; DOI: 10.1016/j.arcped.2025.08.004 AbstractBackground: Pediatric pulmonary arterial hypertension (PAH) is a potentially fatal disease. New targeted therapies based on the underlying pathogenesis are still needed.Objective: This study aims to evaluate the role of leukotriene E4, an inflammatory mediator, in developing pediatric pulmonary arterial

Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study Read More »

Quantitative Evaluation of Lung Perfusion by Dynamic Chest Radiography in Chronic Thromboembolic Pulmonary Hypertension: Comparison With Lung Perfusion Scintigraphy

Megumi Ikeda, Yuzo Yamasaki, Koji Sagiyama, Kazuya Hosokawa, Daisuke Toyomura Tomoyuki Hida, Takuya Hino, Kosuke Tabata, Takuro Isoda, Noritsugu Matsutani, Hidetake Yabuuchi, Kohtaro Abe, Koichi Akashi, Kousei IshigamiKyushu University. Japan Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70170 AbstractPulmonary perfusion assessment is essential for the management of chronic thromboembolic pulmonary hypertension (CTEPH). Lung perfusion scintigraphy and contrast-enhanced

Quantitative Evaluation of Lung Perfusion by Dynamic Chest Radiography in Chronic Thromboembolic Pulmonary Hypertension: Comparison With Lung Perfusion Scintigraphy Read More »

Persistent Low-Output Neonatal Chylothorax: How Long Are We Justified to Wait for Pleurodesis in Partial Responders?

G. Rollo, A. Zarfati, G. Burini, L. Valfre, C. Iacusso, I. Capolupo, B. D. Iacobelli, P. Bagolan, A. Conforti, F. FusaroBambino Gesù Children’s Hospital IRCCS. Italy Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71311 AbstractAims: The aim of our study was to review our experience regarding the management of neonatal chylothorax, with particular focus on outcomes of partial

Persistent Low-Output Neonatal Chylothorax: How Long Are We Justified to Wait for Pleurodesis in Partial Responders? Read More »

Antepartum Thoracocentesis: A Case Report on Congenital Chylothorax

Maria Almeida, Marta Campos, Celia Soares, Cristina Godinho, Maria BritoUnidade Local de Saúde de Trás-os-Montes e Alto.Portugal CureusCureus 2025; 17: DOI: 10.7759/cureus.90275 AbstractCongenital chylothorax remains a poorly understood condition, and the optimal approach to its management continues to evolve. Rapid progression of pleural effusion with mediastinal shift and/or development of hydrops fetalis are key indications for

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Molecular targeted treatment in infants with central conducting lymphatic anomalies

Vera C. van den Brink, Lotte E. R. Kleimeier, Erika K. S. M. Leenders, Willemijn M. Klein, Willem P. de Boode, Joris Fuijkschot, Sabine L. A. G. VranckenAmalia Children’s Hospital, Radboud University Medical Center. Netherlands European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06376-2 AbstractCentral conducting lymphatic anomaly (CCLA) is a rare and potentially life-threatening

Molecular targeted treatment in infants with central conducting lymphatic anomalies Read More »

Incidence and risk factors for the development of pulmonary arteriovenous malformations after stage 2 palliation

Lea Behrend, Thibault Schaeffer, Muneaki Matsubara, Jonas Palm, Teresa Lemmen, Nicole Piber, Paul Philipp Heinisch, Stanimir Georgiev, Alfred Hager, Peter Ewert, Jürgen Horer, Masamichi OnoUniversity Hospital of Technische Universität München, University Hospital of Munich and Ludwig-Maximilians-Universität.Germany International Journal of Cardiology Congenital Heart DiseaseInt J Cardiol Congenit Heart Dis 2025; DOI: 10.1016/j.ijcchd.2025.100611 AbstractObjective: This study evaluated the current

Incidence and risk factors for the development of pulmonary arteriovenous malformations after stage 2 palliation Read More »

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