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Neonatal pulmonary hypertension in the NICU: a 10-year single-center experience

Oguzhan Ay, Sezgin Gunes, Erkan Erfidan, Ayse SimsekIzmir Democracy University and Buca Seyfi Demirsoy Teaching and Research Hospital. Izmir City Hospital. Istanbul Aydin University and VM Medical Park Florya Hospital Istanbul. Turkey BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-05928-7 AbstractBackround Neonatal pulmonary hypertension (PHT) is a significant cause of morbidity and mortality in newborns. Early […]

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Systemic Sirolimus Monitoring in Pediatric Pulmonary Vein Stenosis

Heather Meluskey, Bridget Blowey, Anna B. O’Brien, Michael L. O’Byrne, Jonathan J. Rome, David B. Frank, Catherine M. Avitabile, Mudit Gupta, Jessica Tang, Kimberly L. Butler, Constantine D. Mavroudis, Stephanie Fuller, Ryan CallahanChildren’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania. Dell School of Medicine at the University of Texas.

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Efficacy and safety of treprostinil in pediatric pulmonary hypertension following fontan surgery: a real-world analysis

Mingjie Zhang, Xi Chen, Yahe Xu, Yijun Chen, Zhiyue Zhang, Jingru Zhou, Zhuoming XuShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. China BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-06097-3 AbstractIntroduction: This study aimed to evaluate the efficacy and safety of treprostinil in managing pulmonary hypertension (PH) following Fontan surgery in children. The

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Clinical characteristics and outcomes of neonates with congenital diaphragmatic hernia at the Vietnam National Children’s Hospital: a retrospective observational study

Duong Anh Dang, Thuan Van Nguyen, Dung Thi Thu Nguyen, Dung Thi Pham, Phuong Thi Ha Nguyen, Thuong Duc Nguyen, Tuan Anh Pham, Dung Thi Thuy Le, Mung Thi Ngo, My Ha Nguyen, Hien Hai Dao, Son Hong Pham, Mai Thi Thanh Nguyen, Ha Thi Thu Tran, Son Ngoc Do, Ngoc Huy Nguyen, Chinh Quoc

Clinical characteristics and outcomes of neonates with congenital diaphragmatic hernia at the Vietnam National Children’s Hospital: a retrospective observational study Read More »

Bayesian modelling of oxygen saturation (SpO2) of cardiac patients using the asymmetric generalized error distribution

Tayu Nigusie Abebe, Ayele Taye GoshuKotebe University of Education. Ethiopia BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-06094-6 AbstractBackground: Oxygen saturation (SpO₂) is a crucial parameter for monitoring the health of cardiac patients. It measures the percentage of hemoglobin in the blood that is saturated with Oxygen. The study aims to analyze longitudinal Oxygen saturation (SpO2) levels

Bayesian modelling of oxygen saturation (SpO2) of cardiac patients using the asymmetric generalized error distribution Read More »

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension Read More »

Early postnatal echocardiographic characteristics impact survival and extracorporeal life support in congenital diaphragmatic hernia

Caroline Y. Noh, Enrico Danzer, Shazia Bhombal, Valerie Y. Chock, Neil Patel, Alex Dahlen, Matthew T. Harting, Kevin P. Lally, Ashley H. Ebanks, Krisa P. Van Meurs, Congenital Diaphragmatic Hernia Study GroupChildren’s Hospital Los Angeles and University of Southern California Keck School of Medicine. Stanford University School of Medicine and Lucile Packard Children’s Hospital. Memorial

Early postnatal echocardiographic characteristics impact survival and extracorporeal life support in congenital diaphragmatic hernia Read More »

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH

Abdul S. Mahomed, Anne Burke-Gaffney, Shahin Moledina, Quezia K.Toe, Dongmin Shao, Gregory J. Quinlan, Christopher J. Rhodes, James E. Pease, Stephen JohnWortImperial College London. Great Ormond Street Hospital for Children NHS Foundation Trust. Royal Brompton Hospital.United Kingdom Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-16418-2 AbstractPulmonary arterial hypertension (PAH) is a progressive pulmonary vasculopathy characterized by extensive

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH Read More »

Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension

Akari Sato, Mai Sekine, Hidenori Kawasaki, Masayo Kanai, Hirotaka Ishido, Yoichi Iwamoto, Hideaki Senzaki, Ayumu Masuoka, Fujito Numano, Jun Muneuchi, Norie Mitsushita, Satoshi MasutaniSaitama Medical Center and Saitama Medical University. Nihon Institute of Medical Science. International Medical Center. Niigata University Graduate School of Medical and Dental Sciences. Kyushu Hospital and Japan Community Healthcare Organization. Shizuoka

Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension Read More »

Exploring Health-Related Quality of Life in Children With Pulmonary Hypertension

Jo Wray, Sadia Quyam, Holly Clisby, Vicky Kelly, Shahin MoledinaGreat Ormond Street Hospital for Children NHS Foundation Trust. Barts Heart and Thorax Centre Psychological Services.United Kingdom Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70161 AbstractPulmonary hypertension (PH) in children requires complex medical management. Health-related quality of life (HRQoL) remains understudied in this population. During an 8-month period

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